Blood compatible biological material and preparation method thereof

A technology of blood compatibility and biomaterials, applied in the field of blood compatibility biomaterials and its preparation, to achieve good anticoagulant performance, good anticoagulant performance, and prolong life

Inactive Publication Date: 2006-07-12
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no material that can be used as a material for large and small diameter pipes and organ piping systems in the human body at the same time, especially good anticoagulant properties, high mechanical strength and toughness required by the piping systems of blood vessels or complex organs , a repair material with various performances whose degradation rate matches the growth rate of new tissue

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1 g of polycaprolactone-polyethylene glycol copolymer (PCLPEG) with a molecular weight of 100,000 was dissolved in 100 mL of 1,4-dioxane to prepare a solution with a weight-to-volume concentration of 1%. Weigh 0.1 g of heparin sodium in a beaker, add 3 drops of deionized water to dissolve it, and prepare heparin sodium solution. Add the above-mentioned PCLPEG solution into the heparin sodium solution, stir well and evenly, and prepare two kinds of polymer mixtures. On a porous support membrane, pour a layer of mixed polymer solution, after casting into a film, first go through a rapid drying period to form a dense film layer, and then immerse the film in 0.1% sodium heparin aqueous solution, so that the film has not yet dried Gelation occurs on one side, forming a porous layer. This asymmetric membrane (also called anisotropic membrane) can be used as a biological material such as a dialysis membrane, a filter membrane, a plasma separation membrane, and a cell support ...

Embodiment 2

[0025] Dissolve 20 g of polyurethane with a molecular weight of 10,000 in 100 mL of 1,4-dioxane to prepare a polyurethane solution with a weight-to-volume concentration of 20%. Weigh 0.0001g of streptokinase in a beaker, add 1mL of 0.1M acetic acid to dissolve it to make a solution (dissolve it), add 0.1% of N,N'-dicyclohexyl carbonyl to the total weight of polyurethane Imine (i.e. carbodiimide hydrochloride, EDC) / succinimide (NHS) / 2-N-morpholine-ethane-sulfonic acid (MES) (1:4:2M / M / M) The aqueous solution of the joint system, stir well and evenly. Apply a layer of mixed polymer solution on an iron wire, and form a tube after the solvent evaporates, then soak the tube in a large amount of 0.1% sodium heparin aqueous solution to peel off the iron wire, and remove the cross-linking agent system. This tube can be used to repair various tubular tissues in the human body, and can also be used as a substitute for trachea, nerve guide, blood vessel, bladder, etc. after compoundi...

Embodiment 3

[0027] Dissolve the copolymer of 3-hydroxybutyric acid and 3-hydroxyhexanoic acid (PHBHHx) with a molecular weight of 100,000 in 1000 mL of acetone and reflux at 60°C for 1 h. The 100,000 molecular weight PHBHHx acetone solution was then centrifuged (5000 g, 20 min) to remove insoluble particles. Methanol was added to the suspension to obtain a high-purity PHBHHx precipitate. The purified PHBHHx and polyurethane were dissolved in chloroform at a ratio of 1:10 to prepare a polymer solution with a weight-to-volume concentration of 0.01%. Then mix with 5mL of 1% sodium heparin aqueous solution. The solution was poured on a flat plate to form a film-like material with a thickness of 3 mm. The film-like material thus prepared can be used for the repair or repair of the cardiovascular system. It can also be used as an internal stent for vascular anastomosis or vascular stenosis.

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Abstract

A biological material of blood compatiblility and the preparing method, relating to a biological material of blood compatible used externally or be implanted into body and the preparing method. Dissolving the medical high molecular material of high mechanical property and anticoagulant material with two different solvent and mixing them, fixing the anticoagulant material in the high molecular material uniformly, and preparing the restoring material for tissue organs used externally or be implanted into body with normal process, the invention overcomes the shortcomings existing in traditional technique of not obvious effect or for a short time of the anticoagulant modifying caused by only adsorbing, coating or grafting on the product surface, and makes the material possesses good anticoagulant property and prolongs the anticoagulant durability, and can meet demands of good anticoagulant, biological compatibility, strong mechanical strength and toughness needed by the restoring material for tissue organs used externally or be implanted into body.

Description

technical field [0001] The invention relates to a medical biological material, a tissue and organ repair material for external use or implantation in the body, in particular to a blood-compatible biological material and a preparation method thereof. Background technique [0002] At present, medical biomaterials used in pipeline systems, dialysis systems, artificial lungs, and artificial liver support systems that are in contact with blood generally cause coagulation and thrombus, and the general solution is to use surface modification to make them anticoagulant. enhanced. Once the molecular composition and structure of the material surface change, its anticoagulant performance will decrease or disappear. It is difficult for these materials to maintain their corresponding anticoagulant properties when in contact with blood for a long time, and the service life is generally only a few hours to a few days. [0003] There are many tissue and organ systems in the human body tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L33/00
CPCA61L27/46A61L27/54A61L27/56A61L2300/42
Inventor 颜永年王小红林峰熊卓吴任东张人佶
Owner TSINGHUA UNIV
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