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POSS (Polyhedral Oligomeric Silsesquioxane) fluorosilicone acrylate-polyurethane blood compatible coating and preparation method thereof

A technology of siloxane fluorosilicone acrylate and blood compatibility, applied in the direction of polyurea/polyurethane coatings, coatings, etc., to achieve the effects of easy availability of raw materials, high practical value, and good blood compatibility

Active Publication Date: 2013-12-25
天津渤化讯创科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of POSS fluorosilicone acrylate solution to prepare POSS fluorosilicone acrylate-polyurethane superhydrophobic film on blood compatible materials by spraying has not been reported in the literature

Method used

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  • POSS (Polyhedral Oligomeric Silsesquioxane) fluorosilicone acrylate-polyurethane blood compatible coating and preparation method thereof
  • POSS (Polyhedral Oligomeric Silsesquioxane) fluorosilicone acrylate-polyurethane blood compatible coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Preparation of POSS fluorosilicone acrylate copolymer:

[0023]Preparation of POSS fluorosilicone acrylate copolymer by free radical polymerization: First, 5 g of butyl acetate (BA) and 5 g of methyl isobutyl ketone (MIBK) were added to a four-necked flask as a mixed solvent, and 0.15 g of azobis Isobutylcyanide (AIBN) was used as the initiator. After the temperature rises to 78°C, add 5.5 g of methyl methacrylate (MMA), 4.5 g of butyl acrylate (BA), and hydroxyethyl methacrylate (HEMA) into the four-necked flask dropwise at a rate of 7 ml / h. 1.5g, dodecafluoroheptyl methacrylate (DFMA) 3.5g, polydimethylsiloxane methacrylate (PDMS-MA) 0.8g, methacryloxy oligosilsesquioxane (POSS) 1.5g, AIBN 0.02g and 2g each of BA and MIBK. After the dropwise addition, react for 2-3 hours, then add 2 g each of BA and MIBK and 0.06 g of initiator AIBN into the four-neck flask, and react for 2-3 hours. The whole reaction was carried out under the protection of nitrogen atmosphere....

Embodiment 2

[0032] (1) Preparation of POSS fluorosilicone acrylate copolymer

[0033] Take free radical polymerization to prepare POSS fluorosilicone acrylate copolymer: first add butyl acetate (BA) 5g and methyl isobutyl ketone (MIBK) 5g as mixed solvent in four-necked bottle, and add with 0.12g azobis Isobutylcyanide (AIBN) was used as the initiator. After the temperature rose to 78°C, 6g of methyl methacrylate (MMA), 4g of butyl acrylate (BA), 2g of hydroxyethyl methacrylate (HEMA), Dodecafluoroheptyl methacrylate (DFMA) 3g, polydimethylsiloxane methacrylate (PDMS-MA) 1g, methacryloxy oligomeric silsesquioxane (POSS) 2g, AIBN 0.03g and 3g each of BA and MIBK. After the dropwise addition, react for 2-3 hours, then add 3 g each of BA and MIBK and 0.06 g of initiator AIBN into the four-neck flask, and react for 2-3 hours. The whole reaction was carried out under the protection of nitrogen atmosphere. Excess methanol was precipitated three times, and dried in a vacuum oven for 48 hours...

Embodiment 3

[0042] (1) Preparation of POSS fluorosilicone acrylate copolymer:

[0043] Take free radical polymerization to prepare POSS fluorosilicone acrylate copolymer: first add butyl acetate (BA) 6g and methyl isobutyl ketone (MIBK) 6g as mixed solvent in four-necked bottle, and add with 0.17g azobis Isobutylcyanide (AIBN) was used as the initiator. After the temperature rises to 78°C, add 6.5 g of methyl methacrylate (MMA), 5.5 g of butyl acrylate (BA), and hydroxyethyl methacrylate (HEMA) into the four-necked flask dropwise at a rate of 8 ml / h. 1.5 g, 3.5 g of dodecafluoroheptyl methacrylate (DFMA), 1.5 g of (meth)acryloxy oligomeric silsesquioxane (POSS), 0.03 g of AIBN, and 2 g each of BA and MIBK. After the dropwise addition, react for 2-3 hours, then add 3 g each of BA and MIBK and 0.06 g of initiator AIBN into the four-neck flask, and react for 2-3 hours. The whole reaction was carried out under the protection of nitrogen atmosphere. Excess methanol was precipitated three ti...

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Abstract

The invention discloses a POSS (Polyhedral Oligomeric Silsesquioxane) fluorosilicone acrylate-polyurethane blood compatible coating and a preparation method thereof. The coating is formed on a medical polyvinyl chloride sheet by using a (methyl)acryloxy oligo-POSS fluorosilicone acrylate copolymer and one or two curing agents selected from hexamethylene diisocyanate and isophorone diisocyanate. The preparation method comprises the steps of preparing the POSS fluorosilicone acrylate copolymer into a mixed solution of dichloromethane or ethyl acetate and n-hexane; spraying the solution on the surface of medical polyvinyl chloride through a spray gun to form the coating with good blood compatibility. The POSS fluorosilicone acrylate-polyurethane blood compatible coating and the preparation method thereof have the advantages that the preparation method is simple in process, easy to obtain raw materials and easy to realize industrial and large-scale production; the prepared blood compatible coating has good film forming property and hydrophobicity, favorable blood compatibility and relatively high practical values.

Description

technical field [0001] The invention relates to a (meth)acryloyloxy oligomeric silsesquioxane (POSS) fluorosilicon acrylate-polyurethane blood compatibility coating and a preparation method thereof, belonging to the fields of surface science and biomedical polymer materials. Background technique [0002] With the development of science, more and more biomedical materials are used in clinical medicine. Among them, anticoagulant biomaterials are an important part of biomaterials, and are widely used in medical materials in contact with human blood and tissues. [0003] The superhydrophobic surface has good blood compatibility due to its low surface free energy and low adsorption capacity with various components in blood. Khorasani et al. modified polydimethylsiloxane (PDMS) membranes with superhydrophobic or superhydrophilic properties. In vitro platelet static adhesion experiments showed that compared with pristine PDMS membranes (water contact angle = 105°), the superhydro...

Claims

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Application Information

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IPC IPC(8): C09D175/04C08G18/73C08G18/75C08G18/62C08F220/14C08F220/18C08F220/28C08F220/22C08F230/08
Inventor 赵蕴慧蔡京哲袁晓燕李晓晖李辉
Owner 天津渤化讯创科技有限公司
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