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Oriented polymer/liquid-crystal composite membrane blood compatibility biological material and production thereof

A technology of blood compatibility and biomaterials, which is applied in the field of preparation of oriented polymer/liquid crystal composite membrane blood compatibility biomaterials, can solve problems such as changes in blood components, thrombus formation, investigation and research, and achieve simple and easy operation The effect of rowability, high fluidity, and easy expansion

Inactive Publication Date: 2007-11-21
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] 1. There is a difference between the anticoagulant performance of the composite material and the anticoagulant performance of the artificial organ, so that when the material is in contact with blood, it still directly or indirectly leads to the change of blood components or the formation of thrombus;
[0004] 2. The surface performance of the material has not yet reached the performance of the vascular intima, and there is still a certain gap between the biocompatibility between the material surface and the interface of human tissue and the biocompatibility between human tissue
Tracing it to its cause, one is because the research to the polymer / liquid crystal composite membrane is only limited to macroscopical behavior at this stage, promptly only tests the index of composite material hemocompatibility, does not have the surface morphology structure of composite membrane (such as composite membrane surface liquid crystal domain shape, size, orientation, etc.) for in-depth investigation and research; second, people have not really grasped the relationship between the surface structure characteristics of the material and blood compatibility, and cannot really use the surface structure of the material Molecular design of biomaterials based on the relationship between morphology and blood compatibility

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Weigh 1.95g of medical-grade polyvinyl chloride solid particles, dissolve them in 19.74mL of purified and distilled tetrahydrofuran (AR) under stirring, and prepare a homogeneous solution. Weigh 1.30 g of the purified cholesteric liquid crystal CTgC and dissolve it in 13.16 mL of the above-mentioned purified tetrahydrofuran to prepare a homogeneous solution. According to the mass ratio of liquid crystal and polymer of 1:9, 2:8, 3:7, the homogeneous mixed solution is prepared respectively. Pour the mixed solutions of each proportion into the lower copper template groove respectively, place copper plates of the same size on the upper layer, and connect electrodes to the upper and lower copper plates, and fix the distance between the upper and lower copper plates to be 0.005m. Adjust the voltage of the upper and lower copper plate electrodes to form a uniform electric field between the two copper plates, and the electric field strength is 2.0×10 1 ~4.0×10 1 N / C, using th...

Embodiment 2

[0029] Weigh 1.21 g of medical-grade polyurethane solid particles, dissolve them in 12.25 mL of purified and distilled tetrahydrofuran (AR) under stirring, and prepare a homogeneous solution. Weigh 0.81 g of the purified cholesteric liquid crystal CTC and dissolve it in 8.20 mL of tetrahydrofuran to prepare a homogeneous solution. According to the mass ratio of liquid crystal and polymer of 2:8, 3:7, 4:6, 5:5, 6:4, respectively make uniform mixed solution. Pour each proportioned mixed solution on the bottom copper template respectively, place copper plates of the same size on the upper layer, and connect electrodes to the upper and lower copper plates, fix the distance between the upper and lower copper plates to 0.005m, adjust the voltage of the upper and lower copper plate electrodes, Make a uniform electric field between the two copper plates, the electric field strength is 3.0×10 4 ~4.0×10 4N / C, using the solvent evaporation method to form a film in this uniform electric...

Embodiment 3

[0031] Dissolve 3.5g of medical PVC in 25.06mL of purified and distilled dichloroethane solvent, and stir to make it a uniform solution; weigh 1.62g of purified cholesteric liquid crystal CDC and dissolve it in 11.60mL of dichloroethane to prepare into a homogeneous solution. According to the mass ratio of liquid crystal and polymer of 2:8, 3:7, 4:6, the homogeneous mixed solution is prepared respectively. Pour the mixed solutions of each proportion into the lower copper template groove respectively, place copper plates of the same size on the upper layer, and connect electrodes to the upper and lower copper plates, and fix the distance between the upper and lower copper plates to be 0.005m. Adjust the voltage of the upper and lower copper plate electrodes to form a uniform electric field between the two copper plates, and the electric field strength is 2.0×10 4 ~4.0×10 4 N / C, using the solvent evaporation method to form a film in this uniform electric field at room temperat...

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Abstract

A blood compatible oriented polymer-liquid crystal film is prepared from the polymer (medical polyether-type polyurethane and medical polyvinyl chloride) and the liquid crystal compound (cholesterin-type liquid crystal) through dissolving them is solvent, pouring the solution in a lower copper plate frame connected to an electric pole, putting another copper plate connected another electric pole on it, applying a voltage to generate an electric field for volatalizing the solvent to obtain a film, and vacuum drying. Its advantages are anticoagulation performance able to meet the requirement of human organs, and high biologic compatibility to human body.

Description

technical field [0001] The invention relates to a method for preparing artificial organs and other alignment polymer / liquid crystal composite membrane blood-compatible biomaterials directly in contact with blood. Background technique [0002] The research and development of blood-compatible materials has a long history, from inorganic materials to organic materials; from natural materials, semi-synthetic materials to synthetic materials, all have been selected as blood-compatible materials for research and development. At present, blood-compatible materials in clinical application include medical polyurethane, medical polysiloxane, medical polyvinyl chloride, etc. Zhou Changren of South University once prepared a polymer / liquid crystal composite film to improve the blood compatibility of the material, and obtained Certain results. However, if such composite materials are used to manufacture artificial organs and other biological materials that are in direct contact with blo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/04A61L33/04A61L27/14A61L27/44A61L27/50
Inventor 屠美冯博华
Owner JINAN UNIVERSITY
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