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Preparation method of blood-compatible polypropylene non-woven fabric

A polypropylene non-woven fabric, blood compatibility technology, applied in textiles and papermaking, fiber type, fiber treatment, etc., can solve the problems of low surface energy, poor hydrophilicity, blood coagulation, hemolysis, etc., and achieve high surface energy , Improve antibacterial performance, improve the effect of hydrophilicity

Active Publication Date: 2019-01-22
福建金成纤维制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most polymer materials are non-polar, have low surface energy, and poor hydrophilicity. Coagulation and hemolysis will occur after contact with blood.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] A preparation method of blood-compatible polypropylene non-woven fabric, comprising the following steps:

[0021] (1) In parts by weight, dissolve 22 parts of dimethylamine in 60 parts of ethanol solution with a mass fraction of 90%, then add 18 parts of glycidyl ether to it, mix and stir evenly, and raise the temperature of the mixture to 65 ℃, heat preservation treatment for 4 hours, cooled to room temperature, and purified to obtain component A;

[0022] (2) In parts by weight, dissolve 12 parts of N-[2-[bis(carboxymethyl)amino]ethyl]-N-(2-hydroxyethyl)-glycine trisodium salt in 140 parts of deionized water , and then after passing nitrogen into it, add 0.01 part of inorganic peroxide initiator to it, raise the temperature of the mixture to 65°C, keep it warm for 8 hours, and after standing for stratification, pour off the upper water layer and precipitate the lower layer After washing, component B is obtained;

[0023] (3) After cleaning the polypropylene non-wove...

Embodiment 2

[0032] A preparation method of blood-compatible polypropylene non-woven fabric, comprising the following steps:

[0033] (1) In parts by weight, dissolve 24 parts of dimethylamine in 65 parts of ethanol solution with a mass fraction of 90%, then add 19 parts of glycidyl ether to it, mix and stir evenly, and raise the temperature of the mixture to 68 ℃, heat preservation treatment for 4.5 hours, cooled to room temperature, and purified to obtain component A;

[0034] (2) In parts by weight, dissolve 14 parts of N-[2-[bis(carboxymethyl)amino]ethyl]-N-(2-hydroxyethyl)-glycine trisodium salt in 150 parts of deionized water , and then nitrogen gas was introduced into it, and 0.02 parts of inorganic peroxide initiator was added thereto, and the mixture was heated to 68°C, and after 9 hours of heat preservation reaction, after standing for stratification, the upper water layer was poured out, and the lower layer was precipitated After washing, component B is obtained;

[0035](3) A...

Embodiment 3

[0044] A preparation method of blood-compatible polypropylene non-woven fabric, comprising the following steps:

[0045] (1) In parts by weight, dissolve 26 parts of dimethylamine in 70 parts of ethanol solution with a mass fraction of 90%, then add 20 parts of glycidyl ether to it, mix and stir evenly, and raise the temperature of the mixture to 70 ℃, heat preservation treatment for 5 hours, cooled to room temperature, and purified to obtain component A;

[0046] (2) In parts by weight, dissolve 16 parts of N-[2-[bis(carboxymethyl)amino]ethyl]-N-(2-hydroxyethyl)-glycine trisodium salt in 160 parts of deionized water , and then after passing nitrogen into it, add 0.03 parts of inorganic peroxide initiator to it, raise the temperature of the mixture to 70 °C, keep the temperature for 10 hours, and after standing for stratification, pour off the upper water layer and precipitate the lower layer After washing, component B is obtained;

[0047] (3) After cleaning the polypropyle...

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PUM

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Abstract

The invention discloses a preparation method of a blood-compatible polypropylene non-woven fabric, the preparation method comprises the following operation steps: (1) dimethylamine and glycidyl etherare subjected to addition reaction, and then the mixture is purified to obtain a component A; (2) N-[2] [bis (carboxymethyl)) amino ] ethyl ]-N-(2-hydroxyethyl)) glycinate trisodium is subjected to self-polymerization reaction to obtain a component B; (3) a polypropylene non-woven fabric is cleaned, then is modified liquid by a modification liquid; and (4) the component A and the component B are loaded on the surface of the modified polypropylene non-woven fabric so as to obtain the blood-compatible polypropylene non-woven fabric. The blood-compatible polypropylene non-woven fabric prepared bythe method disclosed by the invention is excellent in mechanical property and high in machinability, the prepared blood-compatible polypropylene non-woven fabric is non-toxic, environment-friendly, high in biochemical stability and long in service life, especially is strong in surface polarity, high in surface energy and remarkable in hydrophilicity, and has extremely excellent anti-protein adsorption capacity and anti-platelet adhesion capability.

Description

technical field [0001] The invention belongs to the technical field of medical polymer materials, and in particular relates to a preparation method of blood-compatible polypropylene nonwoven fabric. Background technique [0002] In recent years, through continuous upgrading and transformation of general-purpose polymer materials with a large amount and a wide range, the cost has been greatly reduced and the performance has been significantly improved. All kinds of new polymer materials that adapt to the development of modern technology are constantly emerging. Among them, the research and development of medical polymer materials that are in contact with blood is one of the important directions for the development of general polymers. Medical devices made of such polymer materials mainly include vascular catheters, vascular stents, artificial heart valves, circulatory support equipment, various extracorporeal circulation tubes, hemodialysis, lung membranes, etc. Due to long-...

Claims

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Application Information

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IPC IPC(8): D06M13/328D06M13/342D06M10/08D06M101/20
CPCD06M10/08D06M13/328D06M13/342D06M2101/20
Inventor 郭艳
Owner 福建金成纤维制品有限公司
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