Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Chitosan-polylactic acid graft copolymer and preparation method and application thereof

A technology of graft copolymer and chitosan, which is applied in medical formula, medical preparation of non-active ingredients, medical science, etc., can solve the problems of polymers with biological toxicity, complex process route, insoluble, etc., and achieve excellent The effect of biocompatibility, good biocompatibility and good mechanical properties

Inactive Publication Date: 2012-06-06
JINAN UNIVERSITY
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since chitin or chitosan is suspended in toluene, it cannot form a homogeneous reaction system with lactide, the grafting rate of the copolymer is low, and it cannot be dissolved in common solvents for polylactic acid
(3) Coupling macromolecular method: Utilize end-formylation polylactic acid oligomer and chitosan coupling to prepare chitosan-polylactic acid copolymer, adopt this method to introduce polylactic acid with molecular weight definite, but the process route is more complicated ( Chinese patent application publication specification CN1418904A, open date May 21, 2003)
[0008] Adopt above-mentioned method to prepare chitosan-polylactic acid graft copolymer, still have following deficiency: use organic solvent and contain heavy metal catalyst in the preparation of copolymer and purification process, their residue will cause polymkeric substance to have biotoxicity, in addition , the grafting rate of the copolymer is not high, and the product purification process is cumbersome, etc.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Chitosan-polylactic acid graft copolymer and preparation method and application thereof
  • Chitosan-polylactic acid graft copolymer and preparation method and application thereof
  • Chitosan-polylactic acid graft copolymer and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Under the catalysis of CCL, chitosan with a degree of deacetylation of 90% and lactide 1:10 (this is the molar ratio of the unit sugar ring number of chitosan to the lactide monomer, the same below).

[0036] Add 0.1118g of chitosan, 1.0000g of lactide and 0.0050g of CCL (put into a bag) into the reactor, seal it, pass carbon dioxide for about 30 minutes to remove the air in the reactor, then close the air inlet and outlet valves, and turn on the electromagnetic Stir and heat. When the temperature reaches 90°C, increase the pressure in the reactor and control it at 40MPa, start recording the reaction time, and the reaction ends after 24 hours; continue to keep the pressure in the reactor at 40MPa and the temperature at 90°C, open the inlet and outlet Air valve, extract a small amount of unreacted monomer (lactide) by supercritical carbon dioxide fluid extraction, until no white powder is ejected from the outlet of the air release valve, the extraction time is about 3h, r...

Embodiment 2

[0040] Implementation of 1:0.1 chitosan and lactide with a degree of deacetylation of 95% under PPL catalysis.

[0041] Add 5.5910g of chitosan, 0.5000g of lactide and 0.0500g of PPL (put into a bag) into the reactor, seal it, pass carbon dioxide for about 30 minutes to remove the air in the reactor, then close the air inlet and outlet valves, and turn on the electromagnetic Stir and heat. When the temperature reaches 60°C, increase the pressure in the reactor and control it at 25MPa, start recording the reaction time, and the reaction ends after 72 hours; continue to keep the pressure in the reactor at 25MPa and the temperature at 60°C, open the inlet and outlet Air valve, extract a small amount of unreacted monomer (lactide) by supercritical carbon dioxide fluid extraction, until no white powder is ejected from the outlet of the air release valve, the extraction time is about 2h, reduce the pressure of the reactor to atmospheric pressure, and then open the reaction The graft...

Embodiment 3

[0043] Implementation of 1:1 chitosan and lactide with a deacetylation degree of 90% under PPL catalysis.

[0044] Add 1.1182g of chitosan, 1.000g of lactide and 0.0200g of PPL (put into the bag) into the reactor, seal it, pass carbon dioxide for about 30 minutes to remove the air in the reactor, then close the air inlet and outlet valves, and turn on the electromagnetic Stir and heat. When the temperature reaches 80°C, increase the pressure in the reactor and control it at 30MPa, start recording the reaction time, and the reaction ends after 24 hours; continue to keep the pressure in the reactor at 30MPa and the temperature at 80°C, open the inlet and outlet Air valve, extract a small amount of unreacted monomer (lactide) by supercritical carbon dioxide fluid extraction, until no white powder is ejected from the outlet of the air release valve, the extraction time is about 4h, reduce the pressure of the reactor to atmospheric pressure, and then open the reaction The graft cop...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
degree of graftingaaaaaaaaaa
degree of graftingaaaaaaaaaa
degree of graftingaaaaaaaaaa
Login to View More

Abstract

The invention provides a chitosan-polylactic acid graft copolymer and a preparation method and an application thereof; the preparation method is to adopt supercritical carbon dioxide fluid as reaction medium and lipase as catalyst to perform graft copolymerization between chitosan or derivative thereof and lactide monomer. The invention is simple to operate, the products are easy to separate, no organic solvent is used in the preparation and purification of the copolymer, the method has no pollution to the environment, and the obtained copolymer has excellent biocompatibility and good mechanical properties so that the copolymer can be used as body-implanted biological materials such as the scaffold for tissue engineering, the carrier for self-assemble micelle drugs, blood compatible material and the like.

Description

technical field [0001] The invention relates to biodegradable medical materials, in particular to a chitosan-polylactic acid graft copolymer and its preparation method and application. Background technique [0002] Polylactic acid has good mechanical and molding properties, biocompatibility and biodegradability, and has been widely used in the field of biomedicine. However, polylactic acid materials are hydrophobic, have poor cell affinity, and the degradation products are acidic, which easily triggers sterile inflammatory reactions and is not conducive to cell growth. [0003] Chitosan is a partial deacetylation product of chitin, a natural polysaccharide with extremely rich sources, non-toxic, non-irritating, good biocompatibility and biodegradability, with free amino groups in its molecule, It is weakly alkaline and can effectively adjust the pH value of the human body; it also has certain physiological activities, which can not only improve the activity and phagocytosis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08C08G63/685C08G63/82A61L27/20A61K47/36
CPCY02P20/54
Inventor 罗丙红程松周长忍
Owner JINAN UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com