Device for removal of noxious agents from blood, extracorporeal perfusion system comprising such device and method for producing such device

An extracorporeal perfusion and harmful substance technology, applied in dialysis systems, separation methods, pharmaceutical devices, etc., can solve problems such as the complexity of hollow fiber membrane manufacturing

Pending Publication Date: 2019-08-30
B BRAUN AVITUM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] However, the method disclosed in document EP 1 776 175 B1 has the disadvantage that for hollow fiber membrane / hollow fiber plasma pretreatment it requires a complex vacuum system with several vacuum chambers, therefore the hollow fiber membrane disclosed therein is very complicated to manufacture

Method used

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  • Device for removal of noxious agents from blood, extracorporeal perfusion system comprising such device and method for producing such device
  • Device for removal of noxious agents from blood, extracorporeal perfusion system comprising such device and method for producing such device
  • Device for removal of noxious agents from blood, extracorporeal perfusion system comprising such device and method for producing such device

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Embodiment Construction

[0079] The drawings are only schematic and are used exclusively for the understanding of the invention. The same elements are provided with the same reference numerals.

[0080] figure 1 Shown is an extracorporeal perfusion system 2 according to the invention comprising a device 4 for removing harmful substances from blood. In this case, the blood of a person 6 is collected, which is pumped to the device 4 via a first line 8 by means of a first pump 10 . Such as figure 2 As shown, the device 4 includes a housing 12 and a plurality of hollow fibers 14 located within the housing 12 . In this case, the blood is basically conveyed to the hollow fibers 14 . The hollow fibers 14 are porous so that at least part of the blood plasma (blood plasma) can be sucked / pumped from the device 4 to a second line 18 by means of a second pump 16 . At least the cellular components of the blood, such as red blood cells, white blood cells or platelets, leave the device 4 through a third line 2...

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Abstract

The invention relates to a device (4) in an extracorporeal perfusion system (2), the invention relates to a device for removing, in particular negatively charged harmful substances (38), the method comprises the following steps: removing blood (44) containing plasma (46) and a cell component (48); the filter comprises a shell (12) and a plurality of hollow fibers (14) arranged in the shell (12), the hollow fibers are configured to allow blood (44) to flow through. Wherein the hollow fibers (14) each have a plurality of pores (34), the hole is arranged to be a hole, wherein the hollow fibers (14) are arranged in such a way that plasma (46) of blood (44) can flow through the holes (34) from the inside of the hollow fibers (14) to the outside of the hollow fibers (14), at the same time, the hollow fibres (14) are subjected to, in particular chemical, modification or pre-treatment, such that they have a functional surface (36) that can bind to and remove the harmful substances (38) from the blood (44). The inner side surface (40) of the hollow fiber (14) is also provided with, in particular, a blood-compatible, anticoagulant, coating (50), which is designed to prevent damage to the cellular components (48) of the blood (44) when the blood (44) flows through the hollow fiber (14). The invention also relates to an extracorporeal perfusion system (2) comprising said device (4) and toa method for producing said device (4).

Description

technical field [0001] The invention relates to a device in an extracorporeal perfusion system for removing, in particular negatively charged, harmful substances from blood containing plasma and cellular components, comprising: a housing and a plurality of Hollow fibers in vivo, the hollow fibers configured to allow blood to flow therethrough, wherein the hollow fibers each have a plurality of holes arranged such that blood plasma can pass through the holes from the hollow fibers The inner side flows to the outer side of the hollow fibers, wherein the hollow fibers are modified or pretreated, in particular chemically, so that they are functional, can bind the harmful substances and remove them from the blood s surface. The invention also relates to an extracorporeal perfusion system comprising said device and a method for manufacturing said device. Background technique [0002] Sepsis, or blood poisoning, is a complex systemic inflammatory response of human tissue due to b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36A61M1/38
CPCA61M1/3627A61M1/3673A61M1/38A61M1/34A61M1/3468A61M1/3679A61M2202/20A61M2207/00B01D39/04B01D67/0088B01D69/08B01D2239/0414B01D2239/0492B01D2323/46A61M1/3431A61M1/3437A61M1/16A61M1/3496A61M1/3621A61M1/3672A61M2205/3334
Inventor 彼得·曼德里
Owner B BRAUN AVITUM
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