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Optical biosensor and covid-19 virus detection device

A biosensor and optical device technology, applied in measurement devices, scientific instruments, biological material analysis, etc., can solve the problems of limited application of antibody detection methods and lack of specificity, and achieve the effect of high detection sensitivity and high detection sensitivity

Active Publication Date: 2022-04-19
WESTLAKE UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, IgG and IgM antibodies are not specific, and influenza and other viral infections can also produce IgG and IgM antibodies in patients. These factors limit the application of antibody detection methods in the prevention and control of the new crown epidemic

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  • Optical biosensor and covid-19 virus detection device

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Embodiment Construction

[0028] In order to understand the purpose, features and advantages of the present invention more clearly, the implementation manners of the present invention will be described in detail below in conjunction with the accompanying drawings. The materials used, those whose manufacturers are not indicated, are conventional products that can be obtained through commercial purchase. The description of the exemplary embodiments is for the purpose of illustration only, and not limitation of the invention and its application.

[0029] 1. Fabrication of Optical Biosensors

[0030] A first aspect of the invention relates to the preparation of optical biosensors.

[0031] (1) Fabrication of Nanoporous Silicon Thin Film Optical Devices

[0032] A nanoporous silicon thin film optical device is prepared on the surface of a single crystal silicon wafer by using an anodic oxidation method (according to conventional procedures in this field). The nanoporous silicon thin film optical device h...

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Abstract

The invention belongs to the technical field of biological detection, and discloses an optical biosensor and a COVID‑19 virus detection device. The optical biosensor provided by the present invention includes a single crystal silicon substrate and a nanoporous silicon thin film optical device arranged on the single crystal silicon substrate, and the nanoporous silicon thin film optical device includes a porous silicon single-layer interference film, a porous silicon A Bragg reflector or a porous silicon microresonator; the surface of the nanoporous silicon thin film optical device is sequentially deposited with a composite metal film and coated with a biological probe. The invention significantly improves the detection sensitivity of the optical biosensor by designing the structure of the nanoporous silicon thin film optical device and depositing a composite metal thin film on the surface of the nanoporous silicon thin film optical device, and is suitable for the detection of pathogens such as COVID-19 virus.

Description

technical field [0001] The invention belongs to the technical field of biological detection, in particular to an optical biosensor and a COVID-19 virus detection device. Background technique [0002] Novel Coronavirus Disease 2019 (COVID-19), referred to as "New Coronary Pneumonia", refers to the pneumonia caused by the 2019 Novel Coronavirus infection, which is an acute respiratory infection. The World Health Organization (WHO) named it "COVID-19" on February 11, 2020. On the same day, the coronavirus research group of the International Committee on Taxonomy of Viruses named the new coronavirus "SARS-CoV-2" according to the naming rules of taxonomy. [0003] Currently, the detection of the novel coronavirus COVID-19 is mainly limited to hospitals and CDCs, and the mainstream technology is polymerase chain reaction based on nucleic acid amplification detection. However, nucleic acid extraction and amplification is a complex process, and the accuracy of the results will be ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/45G01N33/569
CPCG01N21/45G01N33/56983G01N2021/458G01N2333/165
Inventor 荣国光默罕默德·萨万卞素敏苏逸刘鑫鑫
Owner WESTLAKE UNIV
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