Method for constructing blood-compatible coating with degradable polyester

A technology of blood compatibility and degradation of polyester, applied in the direction of coating, can solve the problems of affecting the performance of phosphorylcholine polymers and restricting the wide use of materials, achieving good anti-platelet adhesion, simple operation and wide variety Effect

Inactive Publication Date: 2013-01-23
NORTHWEST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the phosphorylcholine group has excellent biocompatibility, it is difficult to form a stable structure for the existing phosphorylcholine-containing polymers, and the change of the group on the surface seriously affects the phosphorylcholine The performance of choline polymers limits the widespread use of such materials

Method used

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  • Method for constructing blood-compatible coating with degradable polyester
  • Method for constructing blood-compatible coating with degradable polyester
  • Method for constructing blood-compatible coating with degradable polyester

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A 2 mg / mL PBS-PC chloroform solution was prepared, and the coverslip was immersed in the solution and lifted slowly to obtain a uniform coating with an average thickness of 190 nm. Place in air at room temperature for 1 day to completely evaporate the solvent as much as possible. The dynamic contact angle (DCA) was measured, and the average advancing angle was 112°, and the average receding angle was 21°.

Embodiment 2

[0026] Use a micropipette to draw a PBS-PC chloroform solution with a concentration of 2 mg / mL and coat it on the surface of a dry and clean cover glass, and coat evenly to obtain a coating with an average thickness of 184 nm. Place it in the air at room temperature for 1 day to completely evaporate the solvent, and then measure the dynamic contact angle. The average advancing angle is 112° and the average receding angle is 21°. The surface morphology of the coating and the results of adhered platelets are as follows: figure 1 As shown, the platelets have more adhesion on the surface of the polymer coating, and the blood compatibility is poor.

Embodiment 3

[0028] Use a micropipette to draw a PBS-PC chloroform solution with a concentration of 2 mg / mL and coat it on the surface of a dry and clean cover glass, and coat evenly to obtain a coating with an average thickness of 184 nm. Place it in air at room temperature for 1 day to completely evaporate the solvent, then heat it in water at 90 °C for 30 min for hydrophilic treatment, and then measure the dynamic contact angle after cooling to room temperature naturally. The average advancing angle is 92° and the average receding angle is 8°. The coating surface morphology and adhered platelet results after hydrophilic treatment are as follows: figure 2 As shown, there is no platelet adhesion on the surface of the polymer coating with the membrane structure imitating the outer layer of cells, the coating platelet adhesion is reduced by more than 90%, and the blood compatibility is good.

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Abstract

The invention discloses a method for constructing a blood-compatible coating with degradable polyester. The method comprises the following steps of: coating a solution of polybutylenes succinate (PBS-PC) of which the terminal is provided with a phosphorylcholine group onto the surfaces of glass, metal and a high-polymer material to form a coating; and heating in water and performing thermal treatment in vacuum to obtain coatings of different shapes, structures and properties on the surface of a polymer. A simple and practicable method is provided for preparing a blood-compatible coating. The coating with high blood compatibility has research values and wide application prospects in the fields of medicament controlled release, in-vivo short-term implants, medical packing materials such as intravascular stents and the like.

Description

technical field [0001] The invention relates to a method for constructing a blood-compatible coating using amphiphilic degradable aliphatic polyester, in particular to using polybutylene succinate with a phosphorylcholine group at the end to construct a blood-compatible coating The layer method belongs to the field of biomedical polymer materials and polymer chemistry and physics technology. Background technique [0002] At present, various biomedical materials used in artificial organs and interventional therapy devices have become the research and development hotspots of scientists from all over the world. The key issue of biocompatibility, especially blood compatibility, which restricts the wide application of biomedical materials, should be solved as soon as possible. has become increasingly urgent. Aliphatic polyester polymer itself has biodegradability, making it one of the most important biomedical materials and green polymer materials. The macromolecular skeleton o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L31/10
Inventor 宫永宽郝妮张世平
Owner NORTHWEST UNIV
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