Composition for treating infantile eczema and preparation method and application thereof

Abstract

The invention discloses a composition for treating infantile eczema and a preparation method and application thereof.The composition for treating infantile eczema is prepared from, by mass, 60-80 parts of aloe vera gel, 7-9 parts of peach leaf extract, 1-2 parts of codonopsis pilosula extract, 6-8 parts of duckweed extract, 2-3 parts of vitamin C and 1-2 parts of dipotassium glycyrrhizinate. The aloe vera gel, the peach leaf extract, the codonopsis pilosula extract, the duckweed extract, the dipotassium glycyrrhizinate and the vitamin C are compounded, the components are simple, the medicine effect is definite, and the aloe vera gel and the dipotassium glycyrrhizinate mainly provide anti-inflammation and antibacterial effects; the peach leaves and the vitamin C provide antioxidant protection; codonopsis pilosula and vitamin C can promote immunity and skin repair. The duckweed helps to relieve symptoms and regulate the in-vivo environment, and the condition of infantile eczema can be controlled and improved more comprehensively through multi-aspect treatment strategies.

Description

Technical Field

[0001] The present invention relates to the technical field of eczema prevention and treatment, and in particular to a composition for treating pediatric eczema, and a preparation method and application thereof. Background Art

[0002] Eczema is the earliest and most common allergic and inflammatory skin disease in infants and young children. It is an inflammatory skin disease with obvious exudative tendency and easy to recur caused by various internal and external factors. Its inflammation is mainly limited to the superficial dermis and epidermis of the skin, often accompanied by obvious itching, which seriously affects the quality of life of patients. It can occur at any age, any part, and any season. Due to changes in climate and environment, changes in dietary structure, and the accelerated pace of life, the incidence of eczema has been increasing year by year, and the incidence rate in children is higher than that in adults. Modern medicine believes that eczema is a delayed allergic reaction caused by the interaction of various internal and external factors, among which digestive system diseases and autoimmune dysfunction are internal factors; external factors include climate change and food allergies. Western medicine often uses glucocorticoids combined with antihistamines and anti-inflammatory treatments to treat this disease. Although it can quickly and effectively improve the symptoms of eczema, it also has certain side effects. For example, long-term use of glucocorticoids can cause adverse reactions such as local skin pigmentation and capillary dilation, and even "rebound phenomenon" may occur. Therefore, finding a drug that is effective in treating eczema with fewer side effects has become a research hotspot in recent years.

[0003] Traditional Chinese medicine treatment has thousands of years of medical practice experience, and the treatment effect of traditional Chinese medicine is obvious and the adverse reaction is few, so it is widely used in clinical practice. Chinese medicine external treatment refers to a traditional medical treatment method that uses some external medicines to cure diseases by non-oral medicine. Its main absorption pathway and mechanism are: meridian conduction, skin penetration, mucosal absorption. This method is simpler and more efficient than Chinese medicine internal treatment, and it is safer to use, and the medicine can be directly delivered to the lesion site, saving drug resources, and it is also more effective. Patent CN115252731A discloses a Chinese medicine composition for the treatment of eczema and its preparation method and application, which is composed of 17 kinds of Chinese medicinal materials such as Sophora flavescens, Phellodendron chinense, Kochia scoparia, Dictamni, Gentiana scabra, Semen plantaine, Rhizoma alismatis, Smilax glabra, Gardenia jasminoides, Radix scutellariae, Radix sanguisorbae, Radix rehmanniae, Cortex moutan, Radix peony root, stir-fried earthworm, stir-fried Tribulus terrestris, Periostracum cicadae. Patent CN108452226A discloses a Chinese medicine composition for treating pediatric eczema and dermatitis and a preparation method thereof, wherein the Chinese medicine composition comprises more than 20 Chinese medicinal materials, including salvia miltiorrhiza, red peony root, angelica dahurica, kochia fruit, purslane, schizonepeta, cnidium monnieri, dodder seed, sophora flavescens, scutellaria baicalensis, radix stemonae, radix lycii, propolis, mint ice, houttuynia cordata, herba plantain, scutellariae bark, phellodendron, verbena, kudzu root, raspberry, and white mulberry bark. Therefore, the Chinese medicine composition for preventing and treating pediatric eczema in the prior art has the problems of a wide variety of raw materials, high cost, and complicated preparation process, which limits its clinical use. Summary of the invention

[0004] In view of the above-mentioned prior art, the purpose of the present invention is to provide a composition for treating pediatric eczema and its preparation method and application.

[0005] To achieve the above object, the present invention adopts the following technical solutions:

[0006] A first aspect of the present invention provides a composition for treating pediatric eczema, comprising the following components in parts by weight: 60-80 parts of aloe vera gel, 7-9 parts of peach leaf extract, 1-2 parts of Codonopsis pilosula extract, 6-8 parts of duckweed extract, 1-2 parts of dipotassium glycyrrhizinate and 2-3 parts of vitamin C.

[0007] Preferably, the peach leaf extract is prepared by the following method:

[0008] The peach leaves are dried and crushed, and then mixed evenly with distilled water in a mass ratio of 1:8-10, distilled for 4-6 hours, and the distilled components are collected and filtered to obtain the peach leaf extract.

[0009] Preferably, the Codonopsis pilosula extract is prepared by the following method:

[0010] Adding distilled water and complex enzyme to the Codonopsis pilosula stem and root powder, mixing evenly and performing enzymolysis reaction, filtering the obtained enzymolysis solution to obtain the Codonopsis pilosula extract;

[0011] The complex enzyme is prepared by mixing beta-glucosidase, pectinase and cellulase in a mass ratio of (2-4):(1-3):(1-3).

[0012] Preferably, the added amount of the distilled water is 15-20 times the mass of the Codonopsis pilosula stem and root powder; and the added amount of the complex enzyme is 4-10% of the mass of the Codonopsis pilosula stem and root powder.

[0013] Preferably, the temperature of the enzymatic hydrolysis reaction is 40-60°C and the time is 12-16 hours.

[0014] Preferably, the duckweed extract is prepared by the following method:

[0015] The duckweed is crushed, and then an ethanol solution with a volume fraction of 75% to 90% is added, and ultrasonic extraction is performed for 1 to 3 times to obtain an extract; and the duckweed extract is obtained by filtering, concentrating and drying.

[0016] Preferably, the ultrasonic extraction process is as follows: the solid-liquid ratio of duckweed to ethanol solution is 1 g: (10-15) ml, the ultrasonic extraction time is 15-30 min, and the ultrasonic power is 250-350 W.

[0017] The second aspect of the present invention provides a method for preparing the above-mentioned composition for treating pediatric eczema, comprising the following steps:

[0018] Dipotassium glycyrrhizinate, peach leaf extract, Codonopsis pilosula extract, duckweed extract and vitamin C are added to aloe vera gel, and ultrasonic dispersion is performed for 2-4 hours to obtain a composition for treating pediatric eczema.

[0019] The third aspect of the present invention provides use of the above composition for treating pediatric eczema in the preparation of a product for treating eczema.

[0020] Preferably, the product for treating eczema is in the form of an ointment, a lotion or a spray.

[0021] Aloe vera gel is a common natural herbal preparation, and its main functions and effects include moisturizing, soothing and calming, anti-inflammatory and antibacterial, whitening and anti-acne, and anti-aging.

[0022] Peach leaves are bitter and neutral in nature. They enter the liver and kidney meridians and have the effects of clearing away heat and detoxifying, dispelling wind and dampness, promoting blood circulation and relieving pain. They can be used clinically to treat furuncle, rheumatism, bruises, impetigo, carbuncle and other diseases. Existing studies have shown that peach leaf extracts have obvious biological effects in anti-tumor, anti-oxidation, hypoglycemic, antibacterial, analgesic, anti-inflammatory, and skin protection. This is closely related to the fact that peach leaves contain polyphenol compounds, flavonoid compounds and a large number of terpenes with strong antioxidant activity and biological activity.

[0023] Codonopsis pilosula is a plant of the genus Codonopsis in the Campanulaceae family. It is one of the most commonly used Chinese medicines in clinical TCM. Its chemical components mainly include flavonoids, alkaloids, sugars, saponins, steroids, amino acids, etc. It has the following pharmacological effects: enhancing immune system function, improving digestive function, anti-inflammatory, regulating endocrine system, promoting hematopoietic function, regulating cardiovascular and cerebrovascular system, and delaying aging.

[0024] Duckweed is pungent and cold in nature, and enters the lung and bladder meridians. It has the effects of dispersing wind-heat, clearing rashes and relieving itching, and promoting diuresis and reducing swelling. Duckweed is mainly used for measles that does not break out, itching of rubella, edema and oliguria. The apigenin in duckweed has anti-allergic and antipruritic effects.

[0025] Dipotassium glycyrrhizinate, also known as potassium glycyrrhizinate, is a compound extracted from the traditional Chinese medicine licorice. It has anti-inflammatory, anti-ulcer, antioxidant, antibacterial, trauma treatment, and effective scavenging of superoxide ions and hydroxyl radicals.

[0026] The main effects of vitamin C on the skin include improving skin elasticity, promoting skin cell repair and regeneration, anti-oxidation, enhancing skin immunity, and improving urticaria.

[0027] Beneficial effects of the present invention:

[0028] 1. The present invention compounds aloe vera gel, peach leaf extract, Codonopsis pilosula extract, duckweed extract, dipotassium glycyrrhizinate and vitamin C. The ingredients are simple, the efficacy is clear, and there is no toxic ingredient. These ingredients can interact with each other through different pathways in the treatment of pediatric eczema and jointly exert a therapeutic effect. Among them, aloe vera gel and dipotassium glycyrrhizinate mainly provide anti-inflammatory and antibacterial effects; peach leaves and vitamin C provide antioxidant protection; Codonopsis pilosula and vitamin C promote immunity and skin repair; duckweed helps relieve symptoms and regulate the internal environment. Through a multi-faceted treatment strategy, the condition of pediatric eczema can be more comprehensively controlled and improved.

[0029] 2. The ointment of the present invention is easy to prepare, has a wide range of drug sources, is low in cost, and has a high value for promotion and application. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 : Hair growth results on the back of mice in the T1-treated group and the T5-treated group after 13 days of drug administration. DETAILED DESCRIPTION

[0031] It should be noted that the following detailed descriptions are illustrative and are intended to provide further explanation of the present application. Unless otherwise specified, all technical and scientific terms used herein have the same meanings as those commonly understood by those skilled in the art to which the present application belongs.

[0032] In order to enable those skilled in the art to more clearly understand the technical solution of the present application, the technical solution of the present application will be described in detail below in conjunction with specific embodiments.

[0033] The test materials used in the examples of the present invention are all conventional test materials in the art and can be purchased through commercial channels.

[0034] The β-glucosidase used in the present invention was purchased from Shanghai Yuanye Biotechnology Co., Ltd. with the product number S10047-10u.

[0035] The pectinase used in the present invention was purchased from Shanghai Yuanye Biotechnology Co., Ltd. with the product number S10007-5g.

[0036] The cellulase used in the present invention was purchased from Shanghai Yuanye Biotechnology Co., Ltd. with the product number of S10041-5g.

[0037] The vitamin C used in the present invention was purchased from Shanghai Yuanye Biotechnology Co., Ltd. with a product number of S13001-25g and a purity of 99%.

[0038] The aloe vera gel used in the present invention was purchased from Guangzhou Xiya Biotechnology Co., Ltd., with a purity of 98% and a CAS number of 85507-69-3.

[0039] The dipotassium glycyrrhizinate gum used in the present invention was purchased from Luoyang Lansley Technology Co., Ltd. with a purity of 75% and batch number: 2023101123.

[0040] The peach leaf extract used in the present invention is prepared by the following method:

[0041] The peach leaves were dried and crushed, and then mixed evenly with distilled water in a mass ratio of 1:10, and distilled at 100°C for 5 hours. The distilled components were collected and filtered through activated carbon to obtain the peach leaf extract.

[0042] The Codonopsis pilosula extract used in the present invention is prepared by the following method:

[0043] Adding distilled water 15 times the mass of the Codonopsis pilosula stem and root powder and a composite enzyme 7% the mass of the Codonopsis pilosula stem and root powder to the Codonopsis pilosula stem and root powder, mixing evenly, performing an enzymolysis reaction at 40-60° C. for 12 seconds, and filtering the obtained enzymolysis solution with activated carbon to obtain a Codonopsis pilosula extract;

[0044] The complex enzyme is prepared by mixing beta-glucosidase, pectinase and cellulase in a mass ratio of 3:2:2.

[0045] The duckweed extract used in the present invention is prepared by the following method:

[0046] The duckweed is crushed, and then an ethanol solution with a volume fraction of 75% to 90% is added, and ultrasonic extraction is performed for 3 times to obtain an extract; and the duckweed extract is obtained by filtering, concentrating and drying.

[0047] The ultrasonic extraction process is as follows: the solid-liquid ratio of duckweed and ethanol solution is 1g:15ml, the ultrasonic extraction time is 20min, and the ultrasonic power is 300W.

[0048] The preparation method of the above extracts has been appropriately adjusted, please confirm.

[0049] Example 1: Preparation of an ointment for treating eczema in children:

[0050] 1. Raw material composition (by mass): 60 parts of aloe vera gel, 7 parts of peach leaf extract, 1 part of Codonopsis pilosula extract, 6 parts of duckweed extract, 1 part of dipotassium glycyrrhizinate and 2 parts of vitamin C;

[0051] 2. Preparation steps:

[0052] Peach leaf extract, Codonopsis pilosula extract, duckweed extract, dipotassium glycyrrhizinate and vitamin C were added to aloe vera gel, and ultrasonic dispersion was performed for 2 hours under the condition of an ultrasonic power of 150 W to obtain a smear.

[0053] Embodiment 2: the preparation of the ointment for treating eczema in children:

[0054] 1. Raw material composition (by weight): 70 parts of aloe vera gel, 8 parts of peach leaf extract, 1.5 parts of Codonopsis pilosula extract, 7 parts of duckweed extract, 1.5 parts of dipotassium glycyrrhizinate and 2.5 parts of vitamin C;

[0055] 2. Preparation steps:

[0056] Peach leaf extract, Codonopsis pilosula extract, duckweed extract, dipotassium glycyrrhizinate and vitamin C were added to aloe vera gel, and ultrasonic dispersion was performed for 2 hours under the condition of an ultrasonic power of 150 W to obtain a smear.

[0057] Embodiment 3: the preparation of the ointment for treating eczema in children:

[0058] 1. Raw material composition (by weight): 80 parts of aloe vera gel, 9 parts of peach leaf extract, 2 parts of Codonopsis pilosula extract, 8 parts of duckweed extract, 2 parts of dipotassium glycyrrhizinate and 3 parts of vitamin C;

[0059] 2. Preparation steps:

[0060] Peach leaf extract, Codonopsis pilosula extract, duckweed extract, dipotassium glycyrrhizinate and vitamin C were added to aloe vera gel, and ultrasonic dispersion was performed for 2 hours under the condition of an ultrasonic power of 150 W to obtain a smear.

[0061] Comparative Example 1:

[0062] 1. Raw material composition (parts by weight): 80 parts of aloe vera gel, 3 parts of vitamin C, 2 parts of dipotassium glycyrrhizinate and 9 parts of peach leaf extract;

[0063] 2. Preparation steps:

[0064] Peach leaf extract, dipotassium glycyrrhizinate and vitamin C were added to aloe vera gel, and ultrasonic dispersion was performed for 2 h under the condition of an ultrasonic power of 150 W to obtain a smear.

[0065] The difference between this comparative example and Example 3 is that the Codonopsis pilosula extract and the duckweed extract are omitted in the raw material composition.

[0066] Comparative Example 2:

[0067] 1. Raw material composition (by weight): 80 parts of aloe vera gel, 3 parts of vitamin C, 2 parts of dipotassium glycyrrhizinate and 2 parts of Codonopsis pilosula extract;

[0068] 2. Preparation steps:

[0069] Codonopsis pilosula extract, dipotassium glycyrrhizinate and vitamin C were added to aloe vera gel, and ultrasonic dispersion was performed for 2 h under the condition of an ultrasonic power of 150 W to obtain a smear.

[0070] The difference between this comparative example and Example 3 is that peach leaf extract and duckweed extract are omitted in the raw material composition.

[0071] Comparative Example 3:

[0072] 1. Raw material composition (parts by weight): 80 parts of aloe vera gel, 3 parts of vitamin C, 2 parts of dipotassium glycyrrhizinate and 8 parts of duckweed extract;

[0073] 2. Preparation steps:

[0074] Duckweed extract, dipotassium glycyrrhizinate and vitamin C were added to aloe vera gel, and ultrasonic dispersion was performed for 2 h under the condition of an ultrasonic power of 150 W to obtain a smear.

[0075] The difference between this comparative example and Example 3 is that peach leaf extract and Codonopsis pilosula extract are omitted in the raw material composition.

[0076] Comparative Example 4:

[0077] 1. Raw material composition (parts by weight): 80 parts of aloe vera gel, 3 parts of vitamin C and 2 parts of dipotassium glycyrrhizinate;

[0078] 2. Preparation steps:

[0079] Vitamin C and dipotassium glycyrrhizinate were added to aloe vera gel, and ultrasonic dispersion was performed for 2 h under the condition of an ultrasonic power of 150 W to obtain a smear.

[0080] The difference between this comparative example and Example 3 is that peach leaf extract, Codonopsis pilosula extract and duckweed extract are omitted in the raw material composition.

[0081] Test Example 1: Effect of the composition for treating pediatric eczema on the mouse contact eczema model:

[0082] 1. Model construction: Construct a mouse contact eczema model according to the method 2.2.1 in the literature "Research on the preparation process of pediatric eczema gel. Shanghai University of Traditional Chinese Medicine, 2020":

[0083] Preparation of sensitizer:

[0084] 7% DNCB ethanol solution: Accurately weigh 1.05 g DNCB, dissolve it in 15 mL anhydrous ethanol, and sonicate until DNCB is completely dissolved. Protect from light, store in a refrigerator at 4°C, and prepare before use.

[0085] 0.5% DNCB ethanol solution: Accurately weigh 0.05g DNCB, dissolve it in 10mL anhydrous ethanol, and sonicate until DNCB is completely dissolved. Protect from light, store in a refrigerator at 4℃, and prepare before use.

[0086] The day before the experiment, the hair on the back of the mice was removed, with an area of ​​about 2cm×2cm. On the day of the experiment, 100μL of 7% DNCB ethanol solution was applied to the back of the mice for sensitization. Five days later, 25μL of 0.5% DNCB ethanol solution was evenly applied to the front and back of the left ear of the mice as a stimulus. The stimulus was applied once every three days, for a total of four times. The blank control group was smeared with the same amount of ethanol solution. The modeling reaction was observed 30 minutes after each stimulus. The appearance of redness and swelling in the mouse ear indicated that the modeling was successful.

[0087] 2. Experimental groups:

[0088] One hundred contact eczema model mice were selected and randomly divided into 5 groups, with 20 mice in each group.

[0089] The 5 groups of mice with contact eczema model were given medication 30 minutes after the first stimulation and continued for 13 days. The medication conditions of different treatment groups are as follows:

[0090] T1 treatment group: Apply the ointment prepared in Example 3 on the back and left ear of mice, once in the morning and evening every day, 0.1 g each time;

[0091] T2 treatment group: Apply the ointment prepared in Comparative Example 1 on the back and left ear of mice, once in the morning and evening every day, 0.1 g each time;

[0092] T3 treatment group: Apply the ointment prepared in Comparative Example 2 on the back and left ear of mice, once in the morning and evening every day, 0.1 g each time;

[0093] T4 treatment group: Apply the ointment prepared in Comparative Example 3 on the back and left ear of mice, once in the morning and evening every day, 0.1 g each time;

[0094] T5 treatment group: The ointment prepared in Comparative Example 4 was applied on the back and left ear of the mice, once in the morning and evening every day, 0.1 g each time.

[0095] 3. Detection indicators:

[0096] 3.1 Number of times mice scratched their ears: 30 minutes after the last stimulation and drug administration, the mice were allowed to adapt to the cage for 3-5 minutes, and the number of times the mice scratched their ears within 10 minutes was observed. Scratching criteria: The hind paws of the mice scratched the ears and the surrounding areas once or several times continuously. The scratching ended when the hind paws fell to the ground or were licked. Scratching by the forelimbs was not counted.

[0097] 3.2 Poor ear quality of mice: 24 hours after the last stimulation and drug administration, the residual drug in the left ear of the mouse was wiped with normal saline, and the mouse was killed by cervical dislocation. The ears of the mouse were cut along the baseline of the auricle, and holes were punched in the same part of the two ears of the mouse with an 8 mm diameter ear puncher. The ear pieces were weighed, and the mass difference between the two ears was calculated (ear mass difference = left ear mass - right ear mass).

[0098] 3.3 Thickness difference of mouse ears: After weighing the weight of both ears of the mouse, use a vernier caliper to measure the thickness at the same position of both ears of the mouse. Each ear is measured 3 times, and the average value is taken to calculate the thickness difference between the two ears (ear thickness difference = left ear thickness - right ear thickness). The ears of the mouse are stored at -80°C.

[0099] Table 1 Effects of different treatments on mice

[0100] Treatment Group Number of times mice scratched their ears (times) Mouse ear mass difference (mg) Mouse ear thickness difference (mm) T1 0.10 4.28 0.021 T2 1.45 8.43 0.058 T3 1.85 8.98 0.085 T4 1.55 8.27 0.079 T5 2.25 10.75 0.112

[0101] As can be seen from Table 1, the present invention compounded aloe vera gel, peach leaf extract, Codonopsis pilosula extract, duckweed extract, dipotassium glycyrrhizinate and vitamin C, and the T1 treatment group significantly reduced the number of ear scratching of mice, and the ear quality difference and ear thickness difference of mice were also significantly lower than those of other treatment groups, indicating that the ointment prepared in Example 1 has a good therapeutic effect on preventing and treating contact eczema in mice.

[0102] from Figure 1 It can be seen that the hair of mice smeared with the ointment prepared in Example 1 grows faster.

[0103] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A composition for treating pediatric eczema, characterized in that: The invention comprises the following components in parts by weight: 60-80 parts of aloe vera gel, 7-9 parts of peach leaf extract, 1-2 parts of codonopsis pilosula extract, 6-8 parts of duckweed extract, 1-2 parts of dipotassium glycyrrhizinate and 2-3 parts of vitamin C.

2. The composition for treating pediatric eczema according to claim 1, characterized in that: The peach leaf extract is prepared by the following method: The peach leaves are dried and crushed, and then mixed evenly with distilled water in a mass ratio of 1:8-10, distilled for 4-6 hours, and the distilled components are collected and filtered to obtain the peach leaf extract.

3. The composition for treating pediatric eczema according to claim 1, characterized in that: The Codonopsis pilosula extract is prepared by the following method: Adding distilled water and complex enzyme to the Codonopsis pilosula stem and root powder, mixing evenly and performing enzymolysis reaction, filtering the obtained enzymolysis solution to obtain the Codonopsis pilosula extract; The complex enzyme is prepared by mixing beta-glucosidase, pectinase and cellulase in a mass ratio of (2-4):(1-3):(1-3).

4. The composition for treating pediatric eczema according to claim 3, characterized in that: The added amount of the distilled water is 15-20 times the mass of the Codonopsis pilosula stem and root powder; and the added amount of the complex enzyme is 4-10% of the mass of the Codonopsis pilosula stem and root powder.

5. The composition for treating pediatric eczema according to claim 3, characterized in that: The temperature of the enzymatic hydrolysis reaction is 40-60°C and the time is 12-16h.

6. The composition for treating pediatric eczema according to claim 1, characterized in that: The duckweed extract is prepared by the following method: The duckweed is crushed, and then an ethanol solution with a volume fraction of 75% to 90% is added, and ultrasonic extraction is performed for 1 to 3 times to obtain an extract; and the duckweed extract is obtained by filtering, concentrating and drying.

7. The composition for treating pediatric eczema according to claim 6, characterized in that: The ultrasonic extraction process is as follows: the solid-liquid ratio of duckweed to ethanol solution is 1g:(10-15)ml, the ultrasonic extraction time is 15-30min, and the ultrasonic power is 250-350W.

8. The method for preparing the composition for treating pediatric eczema according to any one of claims 1 to 7, characterized in that: The following steps are involved: Dipotassium glycyrrhizinate, peach leaf extract, Codonopsis pilosula extract, duckweed extract and vitamin C are added to aloe vera gel, and ultrasonic dispersion is performed for 2-4 hours to obtain a smear.

9. Use of the composition for treating pediatric eczema according to any one of claims 1 to 7 in the preparation of a product for treating eczema.

10. The use according to claim 9, characterized in that: The dosage form of the product for treating eczema is a cream, a lotion or a spray.

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