Compound ceftiofur suspension emulsion injection and preparation method thereof

Abstract

The invention discloses a compound ceftiofur suspension emulsion injection, which comprises the following components in percentage by mass: 1.5 to 15 percent of ceftiofur hydrochloride, 1.5 to 15 percent of magnolia flower oil, 1 to 10 percent of surfactant, 3 to 30 percent of oil for injection, 0.1 to 1 percent of antioxidant, 0.01 to 0.1 percent of thickening agent, and the balance of water for injection, wherein the sum of the mass percents of the components is 100 percent. The compound ceftiofur suspension emulsion injection has simple operation for the preparation method, strong antibacterial property and lasting pharmacological effect, and avoids stresses caused by multi-time administration of conventional formulations to animals; furthermore, the preparation cost is much lower than that of an oil suspension, and the compound ceftiofur suspension emulsion injection has a very high popularization and application value.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a new dosage form of veterinary medicine, in particular to a suspoemulsion preparation of an animal-specific antibiotic ceftiofur hydrochloride, a preparation method thereof, and an application in medicine. technical background [0002] Ceftiofur is the first third-generation cephalosporin antibiotic specially used for animals. Most ceftiofur injections on the market have a short duration of action and need to be injected once a day for three consecutive days, resulting in a waste of human and financial resources. , also stresses the animal. At present, the long-acting dosage form of ceftiofur hydrochloride injection has been successfully developed and patented. The patent application numbers are 200810226889.X, 200710189747.6, 200710189807.4, 200910114976.0, 200910054708.4. The common feature of these injections is that they are all ceftiofur hydrochloride oil Suspensions, that is, comple...

AI Technical Summary

Problems solved by technology

[0002] Ceftiofur is the first third-generation cephalosporin antibiotic specially used for animals. Most of the ceftiofur injections on the market have a short duration of action and need to be injected once a day for three consecutive days, resulting in a waste of human and financial resources. , also stresses the animals

At present, the long-acting dosage form of ceftiofur hydrochloride injection has been successfully developed and patented. The patent application numbers are 200810226889.X, 200710189747.6, 200710189807.4, 200910114976.0, 200910054708.4. The common feature of these injections is that they are all ceftiofur hydrochloride oil Suspensions, that is, completely use oil for injection as a solvent for various raw materials. Its disadvantage is that it needs to increase the viscosity of the oil, and it cannot be diluted with water for injection during application, which sometimes causes inconvenience in use; completely using oil as a The cost of solvent is relatively high; colloid mill and other instruments are required to grind each active ingredient into fine powder during preparation, and the cost of equipment is relatively high

In addition, long-acting ceftiofur injection is now mainly used as a single prescription, but the pathogen causing respiratory diseases in livestock and poultry has changed from single to mixed infection, which is mainly caused by two or more kinds of viruses, bacteria, mycoplasma, etc. Antibiotic resistance is also a growing problem

Images