Vitamin-D3-contained filling agent for preventing dairy cow mastitis and preparation method of filling agent
A dairy cow mastitis and vitamin technology, applied in the field of veterinary medicine, can solve the problems of reducing the immunity of dairy cows, large doses of antibiotics, antibiotic residues in milk, etc., to improve autoimmunity, improve prevention and treatment effects, and speed up drug effects fast effect
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Embodiment 1
[0044] Example 1 The specific preparation method is as follows:
[0045] (1) Take 20mg of vitamin D3, 50mg of ceftiofur hydrochloride, 0.65g of thickener seaweed polysaccharide, 50mg of antioxidant propyl gallate, and 9.23g of soybean oil for use;
[0046] (2) After mixing vitamin D3 and ceftiofur hydrochloride, disperse with 3.08g of liquid paraffin, and stir ultrasonically for 43 minutes to completely disperse uniformly to obtain a mixture of active ingredients;
[0047] (3) Heat the remaining 6.15g soybean oil to 65°C, then add the thickener trehalose and antioxidant propyl gallate to it in sequence, stir until completely dissolved, and cool to 30°C to obtain a mixture of auxiliary materials;
[0048] (4) Pour the active ingredient mixture into the auxiliary material mixture, stir evenly, then stir with a high-shear emulsifier for 30 minutes, and cool to room temperature to obtain 10g of vitamin D3-containing perfusion agent for preventing and treating dairy cow mastitis.
Embodiment 2
[0049] Example 2 The specific preparation method is as follows:
[0050] (1) Take 50 mg of vitamin D3, 250 mg of ceftiofur hydrochloride, 2 g of thickener glyceryl monostearate, 100 mg of antioxidant propyl gallate, and 7.6 g of liquid paraffin for use;
[0051] (2) After vitamin D3 and ceftiofur hydrochloride are mixed, they are dispersed with 2.53 g of liquid paraffin, and ultrasonically stirred for 47 minutes until they are completely uniformly dispersed to obtain a mixture of active ingredients;
[0052] (3) Heat the remaining 5.07g of liquid paraffin to 80°C, then add 2g of thickener glyceryl monostearate and 100mg of antioxidant propyl gallate to it in sequence, stir until completely dissolved, and cool to 30°C. Obtain a mixture of auxiliary materials;
[0053] (4) Pour the active ingredient mixture into the adjuvant mixture, stir evenly, then stir with a high-shear emulsifier for 50 minutes, and cool to room temperature to obtain 10g of vitamin D3-containing perfusion agent for...
Embodiment 3
[0054] Example 3 The specific preparation method is as follows:
[0055] (1) Take 35mg of vitamin D3, 125mg of ceftiofur hydrochloride, 1.32g of thickener seaweed polysaccharide, 75mg of antioxidant dibutylhydroxytoluene, and 8.44g of soybean oil for use;
[0056] (2) After mixing vitamin D3 and ceftiofur hydrochloride, disperse it with 2.81g soybean oil, and stir ultrasonically for 45 minutes until it is completely dispersed to obtain a mixture of active ingredients;
[0057] (3) Heat the remaining 5.63g of soybean oil to 72.5°C, then add 1.32g of thickener trehalose and 75mg of antioxidant dibutylhydroxytoluene to it in sequence, stir until completely dissolved, and cool to 30°C to obtain auxiliary materials Mixed liquid
[0058] (4) Pour the active ingredient mixture into the auxiliary material mixture, stir evenly, then stir with a high-shear emulsifier for 40 minutes, and cool to room temperature to obtain 10g of vitamin D3-containing perfusion agent for preventing and treating d...
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