Vitamin-D3-contained filling agent for preventing dairy cow mastitis and preparation method of filling agent

A dairy cow mastitis and vitamin technology, applied in the field of veterinary medicine, can solve the problems of reducing the immunity of dairy cows, large doses of antibiotics, antibiotic residues in milk, etc., to improve autoimmunity, improve prevention and treatment effects, and speed up drug effects fast effect

Inactive Publication Date: 2013-04-03
QILU ANIMAL HEALTH PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment of dairy cow mastitis mostly adopts cephalosporin or penicillin antibiotic therapy, but because of the large dose of antibiotics used in this therapy, every 10g of therapeutic drugs contains at least 300mg of antibiotics, which reduces the body weight of cows while curing the disease. Immunity makes dairy cows dependent on antibiotics. In addition, long-term use of antibiotics in large quantities will eventually lead to antibiotic residues in the milk produced

Method used

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  • Vitamin-D3-contained filling agent for preventing dairy cow mastitis and preparation method of filling agent
  • Vitamin-D3-contained filling agent for preventing dairy cow mastitis and preparation method of filling agent
  • Vitamin-D3-contained filling agent for preventing dairy cow mastitis and preparation method of filling agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 The specific preparation method is as follows:

[0045] (1) Take 20mg of vitamin D3, 50mg of ceftiofur hydrochloride, 0.65g of thickener seaweed polysaccharide, 50mg of antioxidant propyl gallate, and 9.23g of soybean oil for use;

[0046] (2) After mixing vitamin D3 and ceftiofur hydrochloride, disperse with 3.08g of liquid paraffin, and stir ultrasonically for 43 minutes to completely disperse uniformly to obtain a mixture of active ingredients;

[0047] (3) Heat the remaining 6.15g soybean oil to 65°C, then add the thickener trehalose and antioxidant propyl gallate to it in sequence, stir until completely dissolved, and cool to 30°C to obtain a mixture of auxiliary materials;

[0048] (4) Pour the active ingredient mixture into the auxiliary material mixture, stir evenly, then stir with a high-shear emulsifier for 30 minutes, and cool to room temperature to obtain 10g of vitamin D3-containing perfusion agent for preventing and treating dairy cow mastitis.

Embodiment 2

[0049] Example 2 The specific preparation method is as follows:

[0050] (1) Take 50 mg of vitamin D3, 250 mg of ceftiofur hydrochloride, 2 g of thickener glyceryl monostearate, 100 mg of antioxidant propyl gallate, and 7.6 g of liquid paraffin for use;

[0051] (2) After vitamin D3 and ceftiofur hydrochloride are mixed, they are dispersed with 2.53 g of liquid paraffin, and ultrasonically stirred for 47 minutes until they are completely uniformly dispersed to obtain a mixture of active ingredients;

[0052] (3) Heat the remaining 5.07g of liquid paraffin to 80°C, then add 2g of thickener glyceryl monostearate and 100mg of antioxidant propyl gallate to it in sequence, stir until completely dissolved, and cool to 30°C. Obtain a mixture of auxiliary materials;

[0053] (4) Pour the active ingredient mixture into the adjuvant mixture, stir evenly, then stir with a high-shear emulsifier for 50 minutes, and cool to room temperature to obtain 10g of vitamin D3-containing perfusion agent for...

Embodiment 3

[0054] Example 3 The specific preparation method is as follows:

[0055] (1) Take 35mg of vitamin D3, 125mg of ceftiofur hydrochloride, 1.32g of thickener seaweed polysaccharide, 75mg of antioxidant dibutylhydroxytoluene, and 8.44g of soybean oil for use;

[0056] (2) After mixing vitamin D3 and ceftiofur hydrochloride, disperse it with 2.81g soybean oil, and stir ultrasonically for 45 minutes until it is completely dispersed to obtain a mixture of active ingredients;

[0057] (3) Heat the remaining 5.63g of soybean oil to 72.5°C, then add 1.32g of thickener trehalose and 75mg of antioxidant dibutylhydroxytoluene to it in sequence, stir until completely dissolved, and cool to 30°C to obtain auxiliary materials Mixed liquid

[0058] (4) Pour the active ingredient mixture into the auxiliary material mixture, stir evenly, then stir with a high-shear emulsifier for 40 minutes, and cool to room temperature to obtain 10g of vitamin D3-containing perfusion agent for preventing and treating d...

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Abstract

The invention provides a vitamin-D3-contained filling agent for preventing dairy cow mastitis and a preparation method of the filling agent. Every 10g of filling agent is prepared from the following materials by weight: 20mg-50mg of vitamin D3, 50mg-250mg of ceftiofur hydrochloride, 0.65g-2g of thickener, 50mg-100mg of antioxidant, and the balance of soybean oil or liquid paraffin. The preparation method of the vitamin-D3-contained filling agent comprises the following steps of: preparing the materials for future use; mixing the vitamin D3 and the ceftiofur hydrochloride, dispersing the obtained mixture by the soybean oil or the liquid paraffin, and ultrasonically stirring the mixture with the soybean oil or the liquid paraffin to uniformly disperse the mixture to obtain active ingredient mixed liquor; heating up residual solvent, and adding the thickener and the antioxidant into the mixture to obtain accessory mixed liquor; pouring the active ingredient mixed liquor into the accessory mixed liquor, uniformly stirring the mixture to obtain the vitamin-D3-contained filling agent for preventing the dairy cow mastitis. The vitamin-D3-contained filling agent is used for preventing and curing the dairy cow mastitis caused by pathogenic bacteria such as staphylococcus aureus, streptococcus, escherichia coli and salmonella.

Description

Technical field [0001] The invention belongs to the field of veterinary medicine, and relates to a vitamin D3-containing perfusion agent for preventing and treating dairy cow mastitis and a preparation method thereof. Background technique [0002] Vitamin D3 is a sterol derivative, and its active metabolites in the body are 25(OH)D3, 1,25(OH) 2 D3, vitamin D3 is metabolized into 25(OH)D3, and 25(OH)D3 is further metabolized and converted into 1,25(OH) by lα-hydroxylase. 2 D3. Research shows that 1,25(OH) 2 D3 is the most important active metabolite of vitamin D3, not only Ca 2+ The main regulator of homeostasis, and can participate in the differentiation and regulation of the immune system. [0003] At present, most of the treatment of dairy cow mastitis uses cephalosporin or penicillin antibiotic therapy. However, due to the large amount of antibiotics used in this therapy, at least 300mg of antibiotics are contained in every 10g of the treatment drug, which reduces the body of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/593A61K31/546A61K9/00A61P15/14A61P31/04
Inventor 王海挺史春云李成应朱祁明崔进孔梅田玉柱
Owner QILU ANIMAL HEALTH PROD
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