Ceftiofur long-acting injection and preparation method thereof

A technology of ceftiofur and ceftiofur hydrochloride, which is applied to medical preparations containing active ingredients, liquid delivery, pharmaceutical formulations, etc., can solve the problems of inconvenient clinical operation, poor safety, short drug action time, etc., and achieves reduction of frequent The effect of drug administration, saving manpower and material resources, and maintaining the therapeutic effect

Inactive Publication Date: 2011-05-18
北京中农大动物保健品技术研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the deficiencies in the preparation process, the 03146062.X scheme still has shortcomings such as short drug action time (3 days), poor safety and inconvenient clinical operation (the injection prepared by the example cannot be used for intramuscular injection)

Method used

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  • Ceftiofur long-acting injection and preparation method thereof
  • Ceftiofur long-acting injection and preparation method thereof
  • Ceftiofur long-acting injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, preparation of ceftiofur long-acting injection

[0038] Prepare ceftiofur long-acting injection with the method of the present invention, and specific method comprises the following steps:

[0039] 1) Get ceftiofur hydrochloride aseptic powder and antioxidant (alpha-tocopherol), and use an ultrafine pulverizer to obtain ceftiofur hydrochloride aseptic micropowder with a particle size less than 25 microns through ultrafine pulverization in the aseptic operation room , α-tocopherol sterile micropowder;

[0040] 2) get suspending agent (aluminum stearate), cross 120 mesh medicine sieves, obtain aluminum stearate superfine powder;

[0041] 3) After the soybean oil for injection is sterilized at a high temperature of 150-160 degrees Celsius for 2 hours (2-3 hours are acceptable), it is placed at room temperature for use;

[0042] 4) Add 10 g of the ultrafine aluminum stearate powder obtained in step 2) to 900 mL of sterilized soybean oil for injection in step...

Embodiment 2

[0045] Embodiment 2, preparation of ceftiofur long-acting injection

[0046] Prepare ceftiofur long-acting injection with the method of the present invention, and specific method comprises the following steps:

[0047] 1) Get ceftiofur hydrochloride aseptic powder and antioxidant (alpha-tocopherol), and use an ultrafine pulverizer to obtain ceftiofur hydrochloride aseptic micropowder with a particle size less than 25 microns through ultrafine pulverization in the aseptic operation room , α-tocopherol sterile micropowder;

[0048] 2) get suspending agent (aluminum stearate), cross 120 mesh medicine sieves, obtain aluminum stearate superfine powder;

[0049] 3) After the soybean oil for injection is sterilized at a high temperature of 150-160 degrees Celsius for 2 hours (2-3 hours are acceptable), it is placed at room temperature for use;

[0050] 4) Add 15 g of the ultrafine aluminum stearate powder obtained in step 2) to 900 mL of sterilized soybean oil for injection in step...

Embodiment 3

[0053] Embodiment 3, preparation of ceftiofur long-acting injection

[0054] Prepare ceftiofur long-acting injection with the method of the present invention, and specific method comprises the following steps:

[0055] 1) Get ceftiofur hydrochloride aseptic powder and antioxidant (alpha-tocopherol), and use an ultrafine pulverizer to obtain ceftiofur hydrochloride aseptic micropowder with a particle size less than 25 microns through ultrafine pulverization in the aseptic operation room , α-tocopherol sterile micropowder;

[0056] 2) Take the suspending agent (polyvinylpyrrolidone) and pass through a 120-mesh drug sieve to obtain a very fine polyvinylpyrrolidone powder;

[0057] 3) Glyceryl triacetate for injection is sterilized at 150-160 degrees Celsius for 2 hours (2-3 hours are acceptable), and placed at room temperature for later use;

[0058] 4) Add 20 g of polyvinylpyrrolidone ultrafine powder obtained in step 2) to 900 mL of sterilized triacetin for injection in step ...

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Abstract

The invention discloses a ceftiofur long-acting injection and a method for preparing the same. The ceftiofur long-acting injection is a suspension injection containing ceftiofur hydrochloride, and the main compositions of the solvent system of the drug are vegetable oil for injection and grease. The preparation process of the ceftiofur long-acting injection has simple operation, and the prepared suspension injection meets the requirements and has obvious long-acting effect after intramuscular injection, so that the therapeutic effect of the drug is improved and the disadvantages that a respiratory disease has a long course and needs multiple administrations in treatment are overcome, and the waste of human resources in a farm caused by frequent administrations and the animal stress reaction caused by multiple administrations are reduced, thus the ceftiofur long-acting injection is a novel veterinary drug preparation with long-acting effect on respiratory diseases of livestock and poultry, and has very high popularization and application value.

Description

technical field [0001] The invention belongs to the field of animal medicines, and specifically relates to an improved preparation of ceftiofur, a cephalosporin antibiotic specially used for veterinary medicine, and a preparation method thereof. Background technique [0002] Ceftiofur (CEF) is a third-generation cephalosporin antibiotic for veterinary medicine and the first cephalosporin antibiotic for animals. Ceftiofur has a wide antibacterial spectrum and strong antibacterial activity, and has strong antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and some anaerobic bacteria; and has a stable β-lactam ring, which is effective against various Bacteria that can produce β-lactamase also have a good killing effect, and it is not easy to produce drug-resistant strains and cross-resistance. It is mainly used clinically for various infections caused by a variety of animal sensitive bacteria. Therefore, the application of ceftiofur in the treatment ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61P31/04A61K9/10
CPCY02A40/70
Inventor 肖希龙汤树生肖俊
Owner 北京中农大动物保健品技术研究院
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