Ceftiofur hydrochloride powder injection as well as preparation method and application thereof

A technology of ceftiofur hydrochloride and ceftiofur, which is used in powder delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. problems, to achieve the effect of no incompatibility, prolonged concentration action time, and increased feed intake

A technology of ceftiofur hydrochloride and ceftiofur, which is used in powder delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. problems, to achieve the effect of no incompatibility, prolonged concentration action time, and increased feed intake

CN104586777AActive Publication Date: 2015-05-06广东省天宝生物制药有限公司
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  • Ceftiofur hydrochloride powder injection as well as preparation method and application thereof
  • Ceftiofur hydrochloride powder injection as well as preparation method and application thereof
  • Ceftiofur hydrochloride powder injection as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of ceftiofur hydrochloride powder injection, comprising the following steps: weighing ceftiofur hydrochloride and sodium carbonate at a weight ratio of 48 (calculated as the active ingredient ceftiofur):28, and putting it into SYH-100 three-dimensional motion In the mixer, after mixing for 15 minutes, transfer to the KGL-120 type antibiotic glass bottle screw dispensing machine for subpackaging to obtain ceftiofur hydrochloride powder injection. The volume of each bottle is 0.1g, 0.2g, 0.5g or 1.0g (both based on the active ingredient ceftiofur), of which, 0.1g and 0.2g specifications are packed in 5-7mL vials, and 0.5g specifications are used in 10-15mL Divided into vials, 1.0g in 20-25mL vials.

[0028] The particle size of ceftiofur hydrochloride is 60-100 mesh.

[0029] The particle size of sodium carbonate is 60-100 mesh.

[0030] The above operations are all carried out in the powder injection purification workshop, and the cleanliness requi...

Embodiment 2

[0032] A preparation method of ceftiofur hydrochloride powder injection, comprising the following steps: weighing ceftiofur hydrochloride and sodium carbonate at a weight ratio of 50:31 (calculated as the active ingredient ceftiofur), and putting them into a SYH-100 three-dimensional motion In the mixer, after mixing for 15 minutes, transfer to the KGL-120 type antibiotic glass bottle screw dispensing machine for subpackaging to obtain ceftiofur hydrochloride powder injection. The volume of each bottle is 0.1g, 0.2g, 0.5g or 1.0g (both based on the active ingredient ceftiofur), of which, 0.1g and 0.2g specifications are packed in 5-7mL vials, and 0.5g specifications are used in 10-15mL Divided into vials, 1.0g in 20-25mL vials.

[0033] The particle size of ceftiofur hydrochloride is 60-100 mesh.

[0034] The particle size of sodium carbonate is 60-100 mesh.

[0035] The above operations are all carried out in the powder injection purification workshop, and the cleanliness r...

Embodiment 3

[0037] A preparation method of ceftiofur hydrochloride powder injection, comprising the following steps: weighing ceftiofur hydrochloride and sodium carbonate at a weight ratio of 52:34 (calculated as the active ingredient ceftiofur), and putting them into a SYH-100 three-dimensional motion In the mixer, after mixing for 15 minutes, transfer to the KGL-120 type antibiotic glass bottle screw dispensing machine for subpackaging to obtain ceftiofur hydrochloride powder injection. The volume of each bottle is 0.1g, 0.2g, 0.5g or 1.0g (both based on the active ingredient ceftiofur), of which, 0.1g and 0.2g specifications are packed in 5-7mL vials, and 0.5g specifications are used in 10-15mL Divided into vials, 1.0g in 20-25mL vials.

[0038] The particle size of ceftiofur hydrochloride is 60-100 mesh.

[0039] The particle size of sodium carbonate is 60-100 mesh.

[0040] The above operations are all carried out in the powder injection purification workshop, and the cleanliness r...

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Abstract

The invention belongs to the technical field of veterinary medicines, and particularly relates to a ceftiofur hydrochloride powder injection as well as a preparation method and an application thereof. The ceftiofur hydrochloride powder injection is prepared from the following effective components ceftiofur hydrochloride and a cosolvent at the weight ratio of (48-52) to (28-34). Ceftiofur sodium is replaced with the ceftiofur hydrochloride; veterinary cefepime hydrochloride powder injection is prepared by weighing the effective components and the cosolvent at the weight ratio of (48-52) to (28-34), mixing evenly, and sub-packaging; and the veterinary cefepime hydrochloride powder injection can be produced and stored at a room temperature. According to the ceftiofur hydrochloride powder injection, the problems that an existing veterinary cefepime hydrochloride powder injection needs to be produced by a freeze-drying method, the raw materials and the preparation need to be stored at a low temperature of 4-10 DEG C, the placement time in a room-temperature or high-temperature season is overlong, and the medication effect is poor due to degradation are solved; the prepared powder injection has the same antibacterial effect as a ceftiofur sodium freeze-dried powder injection; and the ceftiofur hydrochloride powder injection is low in cost and wide in application prospect.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a veterinary ceftiofur hydrochloride powder injection and a preparation method and application thereof. Background technique [0002] Ceftiofur is a bactericidal broad-spectrum antibiotic for veterinary medicine. It is a cephalosporin antibiotic in β-lactam antibiotics. It can kill a variety of Gram-positive and Gram-negative bacteria. It is one of the clinically widely used antibiotics. one. In veterinary medicine, ceftiofur sodium is generally used to make freeze-dried powder injections, and ceftiofur hydrochloride is used to make oily suspension injections, etc., which are used for bacterial respiratory tract infections in pigs and other livestock, as well as E. coli and salmonella in chickens and other poultry. infection. [0003] At present, ceftiofur sodium freeze-dried powder injection has the best application effect in veterinary medicine, and th...

Claims

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Application Information

Patent Timeline
06 May 2015
Publication
CN104586777A
IPC
A61K9/19; A61K31/546; A61P31/04; A61P11/00; A61P13/00; A61P15/00; A61P17/00; A61P1/16; A61P11/02; A61P11/04; A61P27/16
Inventors
李国清; 戴述诚