Disintegration time limit inductive sensor capable of preventing refraction interference

Abstract

The invention relates to the technical field of disintegration time limit automatic induction, in particular to a disintegration time limit inductive sensor capable of preventing refraction interference. A disintegration time limit inductive sensor capable of preventing refraction interference comprises a tube body which is internally provided with a medicine soaking cavity; the conical screen cover corresponds to the bottom of the medicine soaking cavity, the diameter of the upper end of the conical screen cover is larger than that of the lower end of the conical screen cover, and the lower end of the conical screen cover corresponds to the center of the medicine soaking cavity and is provided with an opening; the photoelectric sensor comprises a transmitter and a receiver, the transmitter is fixed below the conical screen cover, and a transmitting port of the transmitter is right opposite to an opening in the lower end of the conical screen cover; the floating head is arranged in the medicine soaking cavity, the receiver is installed in the floating head, and the receiving end of the receiver is exposed out of the bottom of the floating head and right faces the emitting opening of the emitter. And the detection precision of the photoelectric sensor can be effectively prevented from being influenced by refraction and liquid sputtering.

Description

Technical Field

[0001] The present invention relates to the technical field of automatic disintegration time limit sensing, and particularly relates to a disintegration time limit induction sensor for preventing refraction interference. Background Art

[0002] Disintegration means that a solid preparation completely disintegrates, dissolves, or becomes fragmented within the inspection time limit. Except for insoluble coating materials or broken capsule shells, it should pass through a sieve with a 2-mm aperture. The determination of the disintegration time limit uses a lifting disintegrator. Ordinary tablets should completely disintegrate within 15 minutes, hard capsules in capsule preparations should completely disintegrate within 30 minutes, and soft capsules should completely disintegrate within one hour. The confirmation of the disintegration time limit generally uses visual observation, which has subjective errors and consumes manual working hours.

[0003] In order to reduce labor costs and avoid subjective errors in manual detection, an underwater photoelectric sensor can monitor the disintegration time limit of drugs, but it has the following poor stability performance: On the one hand, during the disintegration operation, the tube body needs to move up and down, which may cause the receiver of the photoelectric sensor to be placed above the liquid surface. Then, the light signal of the transmitter needs to pass through the solution and air to be received by the receiver, and refraction will occur during this process, resulting in the receiver not being able to receive the light signal in a timely manner; On the other hand, during the up and down movement of the tube body, it will drive the shaking of the solution in the tube body, resulting in the sputtering of the solution in the tube body, thereby interfering with the accuracy of the receiver receiving the light signal. Summary of the Invention

[0004] To overcome the deficiencies of the above-mentioned prior art, the present application provides a disintegration time limit induction sensor for preventing refraction interference, which can effectively avoid the influence of the photoelectric sensor on the detection accuracy due to refraction and liquid sputtering.

[0005] To achieve the above object, the present invention is implemented through the following technical solutions: A disintegration time limit induction sensor for preventing refraction interference, comprising: A tube body, with a medicine immersion cavity provided inside the tube body; A conical sieve cover corresponding to the bottom of the medicine immersion cavity, the upper diameter of the conical sieve cover is larger than the lower diameter, and the lower end of the conical sieve cover corresponds to the central position of the medicine immersion cavity and is provided with an opening; A photoelectric sensor, the photoelectric sensor includes a transmitter and a receiver, the transmitter is fixed below the conical sieve cover, and the emission port of the transmitter is directly opposite to the opening at the lower end of the conical sieve cover; A floating head placed in the medicine immersion cavity, the receiver is installed inside the floating head, and the receiving end of the receiver exposes at the bottom of the floating head and is directly opposite to the emission port of the transmitter.

[0006] Further, a disintegration time limit induction sensor for preventing refraction interference in the present application further includes a transmitter mounting bracket, and the transmitter mounting bracket is connected to the lower end of the tube body. The transmitter mounting bracket includes a base, and an installation counterbore is provided at the bottom of the base. The transmitting end of the transmitter is arranged in the installation counterbore, and a light-transmitting through hole corresponding to the transmitting port of the transmitter penetrates through the top of the installation counterbore.

[0007] Further, for a disintegration time limit induction sensor for preventing refraction interference in the present application, a conical fitting surface is provided at the upper end of the base, and the lower end of the conical bottom surface of the conical screen cover is fitted with the conical fitting surface.

[0008] Further, for a disintegration time limit induction sensor for preventing refraction interference in the present application, the conical screen cover includes a conical bottom and an annular sleeve integrally connected. The conical bottom is arranged below the annular sleeve, and the annular sleeve is sleeved on the outer wall of the tube body; The transmitter mounting bracket further includes a collar. The collar is arranged above the base. A set of connecting plates is circumferentially provided at the lower end of the collar. The bottom of the connecting plate is connected to the base. A limiting groove portion is provided on the inner wall of the collar. The top end of the annular sleeve is arranged in the limiting groove portion on the inner wall of the collar, and the collar is sleeved on the outer wall of the tube body.

[0009] Further, for a disintegration time limit induction sensor for preventing refraction interference in the present application, the radial dimension of the floating head is adapted to the radial dimension of the medicine immersion cavity.

[0010] Further, for a disintegration time limit induction sensor for preventing refraction interference in the present application, a set of upper and lower through notches is provided on the side wall of the floating head.

[0011] From the above technical solutions, the present invention has the following beneficial effects: Based on the above device, for a disintegration time limit induction sensor for preventing refraction interference in the present application, when performing the disintegration operation, the medicine is placed in the medicine immersion cavity, and the tube body is immersed in the solvent and moved up and down by external drive. The solvent immerses into the medicine immersion cavity through the mesh holes of the conical screen cover to dissolve the medicine. During this process, the floating head floats on the solvent in the medicine immersion cavity, the medicine is between the transmitter and the receiver, and the receiving end of the receiver is always immersed in the liquid surface. Therefore, for a disintegration time limit induction sensor for preventing refraction interference in the present application, on the one hand, due to the setting of the floating head, it can ensure that the receiving end of the receiver is always immersed in the solvent, so it can ensure that the optical signal emitted by the transmitter to the receiver only propagates in the solvent. Therefore, the optical signal will not be refracted and interfered due to the water surface oscillation, resulting in the receiver being unable to receive the signal in time; on the other hand, since the floating head floats on the solvent in the medicine immersion cavity, it can slow down the bubbles generated by the splashing of the solvent liquid surface in the medicine immersion cavity caused by the up and down movement of the tube body, so as to ensure the accuracy of detecting the end point of the disintegration time limit. Description of the Drawings

[0012] Figure 1 A three-dimensional structural schematic diagram of a disintegration time limit end timing device according to an embodiment of the present application; Figure 2 A structural schematic diagram of the lifting drive device; Figure 3 An installation schematic diagram of a Hall sensor and an induction magnet block in a disintegration time limit end timing device according to an embodiment of the present application; Figure 4 A three-dimensional structural schematic diagram of the hanging basket; Figure 5 An exploded view of the components of the hanging basket; Figure 6 A sectional view of the hanging basket; Figure 7 For Figure 6 A partial enlarged view of the area of circle A in

[0013] In the figure: 1 - Disintegrator main body; 11 - Water bath tank; 12 - Lifting drive device; 121 - Rotary transmission member; 122 - Linear movement assembly; 123 - Induction magnet block; 124 - Lifting rod; 125 - Extension plate; 126 - Suspension rod; 13 - Hall sensor; 2 - Hanging basket; 21 - Tube body; 22 - Conical screen cover; 221 - Conical bottom; 222 - Ring sleeve; 23 - Upper limit disk; 24 - Lower limit disk; 25 - Connecting rod; 251 - Positioning nut; 252 - Through wire groove; 253 - Limit cap; 254 - Mounting plate; 255 - Wire through hole; 26 - Support plate; 3 - Beaker; 4 - Photoelectric sensor; 41 - Transmitter; 42 - Receiver; 421 - Floating head; 422 - Notch; 5 - Transmitter mounting bracket; 51 - Base; 511 - Mounting counterbore; 512 - Light transmission through hole; 513 - Conical fitting surface; 5134 - Limit platform; 52 - Collar; 53 - Connecting plate. Detailed implementation manners

[0014] Embodiment 1 Combined with Figures 5 to 7 A disintegration time limit induction sensor for preventing refraction interference shown, a disintegration time limit induction sensor for preventing refraction interference, including: A tube body 21, and a medicine immersion cavity is arranged in the tube body 21; A conical screen cover 22 corresponding to the bottom of the medicine immersion cavity, the upper end diameter of the conical screen cover 22 is larger than the lower end diameter, and the lower end of the conical screen cover 22 corresponds to the central position of the medicine immersion cavity and is provided with an opening; Photoelectric sensor 4, the photoelectric sensor 4 includes a transmitter 41 and a receiver 42, the transmitter 41 is fixed below the conical screen cover 22, and the transmitting port of the transmitter 41 is directly opposite to the opening at the lower end of the conical screen cover 22; The floating head 421 is placed in the medicine soaking chamber, and the receiver 42 is installed in the floating head 421 . The receiving end of the receiver 42 is exposed at the bottom of the floating head 421 and is directly opposite to the transmitting port of the transmitter 41 .

[0015] The principle of the above sensor for disintegration time monitoring is: the medicine placed in the tube body 21 sinks to the bottom of the tube body 21, and due to the setting of the conical screen cover 22, the medicine will automatically occupy the center position of the conical screen cover 22 due to gravity, and just block the launch port of the transmitter 41 at this time. When the disintegration experiment is carried out, when the hanging basket 2 moves upward, the medicine will fit with the conical screen cover 22, and it can be ensured that the undisintegrated medicine blocks the launch port of the transmitter 41, so that the receiver 42 cannot detect the light signal emitted by the transmitter 41; when the medicine is completely disintegrated, at this time, there is no obstruction between the transmitter 41 and the receiver 42, and the receiver 42 can receive the light signal, so as to start the stop timing, output the timing data, and obtain the end time of the disintegration time. It should be noted that the reciprocating frequency of the up and down movement of the hanging basket 2 specified in the Pharmacopoeia is 30 to 32 times per minute, so the theoretical error of the disintegration time timing of the disintegration time end timing device of the present embodiment is 1 second. Therefore, the disintegration time limit endpoint timing device of this embodiment can realize the automatic timing of the disintegration time limit endpoint of the drug to be tested, saving manpower, and has the advantages of low manufacturing cost, simple control principle and good reliability compared with the existing technical solutions for automatic detection of disintegration end point. Among them, the photoelectric sensor 4 is preferably an underwater infrared photoelectric sensor.

[0016] In this embodiment, on the one hand, due to the setting of the floating head 421, it can ensure that the receiving end of the receiver 42 is always immersed in the solvent, so that the optical signal emitted by the transmitter 41 to the receiver 42 is only propagated in the solvent, so the optical signal will not be refracted and disturbed by the vibration of the water surface, resulting in the receiver 42 being unable to receive the signal in time; on the other hand, since the floating head 421 floats on the solvent in the immersion chamber, it can slow down the bubbles generated by the splashing of the solvent liquid surface in the immersion chamber due to the up and down movement of the tube body 21, so as to ensure the accuracy of detecting the end point of the disintegration time limit.

[0017] Specifically, in this embodiment, the positions of the receiving port and the transmitting port of the receiver 42 and the transmitter 41 correspond to the axis core of the tube body 21 .

[0018] In this embodiment, it further includes a transmitter mounting bracket 5. The transmitter mounting bracket 5 is installed at the lower end of the tube body 21 and is connected to the tube body 21. The transmitter mounting bracket 5 includes a base 51. There is an installation counterbore 511 at the bottom of the base 51. The emitting end of the transmitter 41 is arranged in the installation counterbore 511. A light-transmitting through-hole 512 penetrates through the top of the installation counterbore 511, and the light-transmitting through-hole 512 corresponds to the emission port of the transmitter 41. The aperture of the light-transmitting through-hole 512 is less than or equal to the sieve holes of the conical screen cover 22. The aperture size of the sieve holes of the disintegrator is the size specified in the Pharmacopoeia, such as 2 mm. When the particulate matter after the drug disintegrates is smaller than the sieve holes of the conical screen cover 22, it is considered that the disintegration is completed. Therefore, the light-transmitting through-hole 512 is smaller than the sieve holes of the conical screen cover 22, which can ensure that the drug that has not completed disintegration can cover the light-transmitting through-hole 512. The light-transmitting through-hole 512 is vertically through. The setting of the light-transmitting through-hole 512 and the installation counterbore 511 can prevent the diffuse reflection of the optical signal emitted by the transmitter 41, resulting in the receiver 42 receiving the optical signal in advance and causing errors. In this embodiment, the installation counterbore 511 is threadedly connected to the transmitter 41, and the light-transmitting through-hole 512 corresponds to the axis position of the tube body 21.

[0019] Combined with Figure 7 As shown, in this embodiment, a conical fitting surface 513 is provided at the upper end of the base 51. The lower end of the conical bottom surface of the conical screen cover 22 is fitted with the conical fitting surface 513. A limiting platform 5134 extends from the center of the conical fitting surface 513, and the edge of the lower end opening of the conical screen cover 22 is fitted with the limiting platform 5134. In this embodiment, the transmitter mounting bracket 5 further includes a collar 52. The collar 52 is arranged above the base 51. A group of connecting plates 53 are circumferentially provided at the lower end of the collar 52. The bottom of the connecting plates 53 is connected to the base 51. The collar 52 is sleeved on the outer wall of the tube body 21. By connecting the collar 52 and the base 51 through the connecting plates 53, the overall shape of the transmitter mounting bracket 5 is a hollow frame shape, which can ensure the circulation of the solvent.

[0020] Combined with Figure 5As shown in the figure, in this embodiment, the conical screen cover 22 includes a conical bottom 221 and an annular sleeve 222 that are integrally connected. The conical bottom 221 is arranged below the annular sleeve 222, and the annular sleeve 222 is sleeved on the outer wall of the tube body 21. The conical surface inside the conical bottom 221 fits against the bottom of the tube body 21 to realize the limitation of the conical screen cover 22 relative to the tube body 21. When the conical bottom 221 is separated from the bottom edge of the tube body 21, the annular sleeve 222 can prevent a gap from being generated between the conical screen cover 22 and the tube body 21, so that the medicine inside the tube body 21 does not leak out from the gap. In this embodiment, a limiting groove portion is provided on the inner wall of the collar 52, and the top end of the annular sleeve 222 is arranged in the limiting groove portion on the inner wall of the collar 52. Therefore, in this embodiment, the conical screen cover 22 is integrally embedded between the collar 52 and the conical fitting surface 513 of the transmitter mounting bracket 5, and the overall fixing effect is reliable. When the hanging basket 2 moves up and down reciprocally, it can effectively prevent the conical screen cover 22 from falling off relative to the transmitter mounting bracket 5.

[0021] Furthermore, in this embodiment, the radial dimension of the floating head 421 is adapted to the radial dimension of the medicine-soaking cavity to ensure that the receiver 42 is always directly opposite the transmitter 41 during the movement of the floating head 421. In addition, a set of notches 422 that penetrate up and down are provided on the side wall of the floating head 421. The provision of the notches 422 prevents the floating head 421 from causing an airtight blockage to the tube body 21.

[0022] Embodiment 2 Combined with Figures 1 to 5 A disintegration time limit end timing device shown in the figure includes a disintegrator main body 1. The disintegrator main body 1 includes a water bath tank 11 and a lifting drive device 12, and also includes a beaker 3 and a hanging basket 2. The beaker 3 is arranged in the water bath tank 11, the hanging basket 2 is arranged in the beaker 3, and the lifting drive device 12 can drive the hanging basket 2 to move up and down reciprocally in the beaker 3; A set of disintegration time limit induction sensors for preventing refraction interference in Embodiment 1 are installed on the hanging basket 2, and the transmitter 41 and the receiver 42 are electrically connected to the disintegrator control system; The lifting drive device 12 includes a rotary transmission member 121 and a linear movement assembly 122. The rotary transmission member 121 is in transmission connection with the linear movement assembly 122. The linear movement assembly 122 is connected to the hanging basket 2, and an induction magnetic block 123 is provided on the rotary transmission member 121; A Hall sensor 13 is also included. The Hall sensor 13 is arranged on one side of the induction magnetic block 123, and the Hall sensor 13 is electrically connected to the disintegrator control system; When the rotary transmission member 121 drives the induction magnetic block 123 to rotate to a position corresponding to the Hall sensor 13, at this time, the linear movement assembly 122 is in an upward movement stroke.

[0023] In this embodiment, the number of tube bodies 21 is 6, and they are arranged at circumferentially uniform intervals. A method for using a disintegration time limit end timing device in this embodiment includes the following steps: S1: Preparation. Solvents are placed in the water bath 11 and the beaker 3, the hanging basket 2 is immersed in the beaker 3, and the lifting drive device 12 is connected to the hanging basket 2. S2: Start. The drug to be tested is placed into the tube body 21, the disintegrator is started, and the lifting drive device 12 drives the hanging basket 2 to move up and down in the beaker 3. Meanwhile, the counting module of the disintegrator control system starts timing. To prevent the drug from moving up and down for too long, a limit cover (not shown) that can sink into the solution in the medicine immersion cavity can be set to cover the drug. The limit cover is provided with a through hole whose position is directly opposite to the emitter 41, and the size of the through hole is the same as the mesh hole of the conical screen cover 22.

[0024] S3: Emit optical signal. When the hanging basket 2 moves upward, the induction magnet 123 rotates to a position corresponding to the Hall sensor 13. At this time, the Hall sensor 13 outputs a signal to the controller, and the controller controls the emitter 41 to emit an optical signal. S4: End timing. After the drug is completely disintegrated, there is no obstacle between the receiver 42 and the emitter 41. When the receiver 42 receives the optical signal emitted by the emitter 41, the corresponding counter stops timing and outputs the timing data. Among them, the output objects of the timing data include but are not limited to the display screen, computer, and printer.

[0025] In this embodiment, when the rotary transmission member 121 rotates one week, the linear movement assembly 122 completes one lift. The induction magnet 123 is arranged on the rotary transmission member 121, and the Hall sensor 13 is fixed at a preset position. Since the rotation stroke position of the rotary transmission member 121 and the movement position (including direction parameters) of the linear movement assembly 122 can correspond one by one, the Hall sensor 13 can be used to detect when the rotary transmission member 121 rotates to the preset position to determine that the hanging basket 2 is in the upward movement state. The rotary transmission member 121 can be a cam or a crank, and the above functions are realized by adopting a cam and push rod mechanism or a crank and slider mechanism. In this embodiment, the rotary transmission member 121 is an eccentric wheel, and the lower end of the linear movement assembly 122 is in contact connection with the upper end of the eccentric wheel.

[0026] Combined with Figure 4 and Figure 6As shown in the figure, in this embodiment, the hanging basket 2 includes an upper limit disk 23 and a lower limit disk 24. The upper limit disk 23 is arranged at the upper end of a group of pipe bodies 21. A group of pipe bodies 21 are arranged through the lower limit disk 24. The upper limit disk 23 and the lower limit disk 24 are provided with limit holes adapted to the pipe bodies 21. It also includes a connecting rod 25. The connecting rod 25 penetrates through the upper limit disk 23 and the lower limit disk 24. A group of positioning nuts 251 are sleeved on the outer wall of the connecting rod 25. The positioning nuts 251 realize the axial positioning of the upper limit disk 23 and the lower limit disk 24 relative to the connecting rod 25. The upper end of the connecting rod 25 is connected to the lifting drive device 12. By driving the connecting rod 25 through the lifting drive device 12, the overall up and down movement of the hanging basket 2 is realized. It should be noted that a radially inward extending retaining edge is provided at the upper end of the limit hole corresponding to the pipe body 21 on the upper limit disk 23 to realize the limit of the upper end of the pipe body 21.

[0027] Combined with Figure 6 and Figure 7 As shown in the figure, in this embodiment, the connecting rod 25 is a hollow pipe body with openings at both ends. The lower end of the connecting rod 25 extends to correspond to the transmitter 41. The connecting rod 25 in the shape of a hollow pipe body is used to thread a group of wires of the transmitter 41 to prevent the wires of the transmitter 41 from swinging, winding and interfering when the hanging basket 2 moves up and down. In this embodiment, a group of wire grooves 252 are circumferentially arranged at the lower end of the connecting rod 25. A group of wire grooves 252 correspond to a group of transmitters 41 one by one. A limit cap 253 is connected to the bottom of the connecting rod 25. The wire grooves 252 are used to lead out the wires, and the limit cap 253 can limit the lower end of the wires.

[0028] Combined with Figure 4 As shown in the figure, in this embodiment, the hanging basket 2 further includes a support plate 26. The support plate 26 is connected below the lower limit disk 24 through a group of bolts. The upper end of the support plate 26 is in contact with the bottom surface of the base 51. The support plate 26 realizes the limit of the bottom of the transmitter mounting bracket 5 through bolts and nuts. The whole can improve the firmness of the connection between the transmitter mounting bracket 5 and the conical screen cover 22 relative to the pipe body 21. In this embodiment, the top end of the collar 52 is in contact with the upper limit disk 23. And the whole is detachable, which is convenient for cleaning and maintenance.

[0029] Combined with Figure 1 and Figure 2 As shown in the figure, in this embodiment, an installation plate 254 is provided at the top of the connecting rod 25. A wire through hole 255 is provided on the installation plate 254. The wire through hole 255 is used to thread the wire extended from the receiver 42. The linear movement assembly 122 includes a lifting rod 124. The rotary transmission member 121 extends from the upper end of the disintegrator main body 1. An extension plate 125 is provided on the rotary transmission member 121. A pair of suspension rods 126 are fixed on the linear movement assembly 122. A pair of induction magnetic blocks 123 are connected to the installation plate 254.

[0030] The technical principle of the present invention has been described in combination with specific embodiments above. These descriptions are only for explaining the principle of the present invention and cannot be construed as a limitation on the protection scope of the present invention in any way. Based on the explanations herein, those skilled in the art can readily conceive of other specific embodiments of the present invention without creative efforts, and these embodiments will fall within the protection scope of the present invention.

Claims

1. A disintegration time limit induction sensor with anti-refraction interference, characterized in that: include: The pipe body (21) is provided with a chemical dipping chamber; A conical screen cover (22) corresponding to the bottom of the medicine soaking chamber, wherein the diameter of the upper end of the conical screen cover (22) is greater than the diameter of the lower end, and the lower end of the conical screen cover (22) corresponds to the central position of the medicine soaking chamber and is provided with an opening; A photoelectric sensor (4), the photoelectric sensor (4) comprising a transmitter (41) and a receiver (42), the transmitter (41) being fixed below the conical screen cover (22), the transmitting port of the transmitter (41) being directly opposite to the opening at the lower end of the conical screen cover (22); A floating head (421) is placed in the medicine soaking chamber, and a receiver (42) is installed in the floating head (421). The receiving end of the receiver (42) is exposed at the bottom of the floating head (421) and is directly opposite to the transmitting port of the transmitter (41).

2. The disintegration time induction sensor with anti-refraction interference according to claim 1, characterized in that: The device also comprises a transmitter mounting frame (5), the transmitter mounting frame (5) being connected to the lower end of the tube body (21), the transmitter mounting frame (5) comprising a base (51), a mounting countersunk hole (511) being provided at the bottom of the base (51), an emitting end of the transmitter (41) being arranged in the mounting countersunk hole (511), and a light-transmitting through hole (512) corresponding to the emitting port of the transmitter (41) being provided at the top of the mounting countersunk hole (511).

3. The disintegration time induction sensor with anti-refraction interference according to claim 2, characterized in that: The upper end of the base (51) is provided with a conical fitting surface (513), and the lower end of the conical bottom surface of the conical screen cover (22) fits with the conical fitting surface (513).

4. The disintegration time limit induction sensor with anti-refraction interference according to claim 2, characterized in that: The conical screen cover (22) comprises a conical bottom (221) and an annular sleeve (222) which are integrally connected, the conical bottom (221) being arranged below the annular sleeve (222), and the annular sleeve (222) being sleeved on the outer wall of the tube body (21); The launcher mounting frame (5) further comprises a collar (52), the collar (52) being arranged above the base (51), a group of connecting plates (53) being arranged circumferentially at the lower end of the collar (52), the bottom of the connecting plates (53) being connected to the base (51), a limiting groove being arranged on the inner wall of the collar (52), the top end of the annular sleeve (222) being arranged in the limiting groove on the inner wall of the collar (52), and the collar (52) being sleeved on the outer wall of the tube body (21).

5. The disintegration time induction sensor with anti-refraction interference according to claim 1, characterized in that: The radial dimension of the floating head (421) is adapted to the radial dimension of the medicine soaking chamber.

6. The disintegration time induction sensor with anti-refraction interference according to claim 5, characterized in that: The side wall of the floating head (421) is provided with a group of notches (422) that penetrate vertically.

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