4 results about "Toxicity profile" patented technology

The present invention provides, among other things, a novel class of cationic lipid compounds (e.g., cationic lipids having a structure according to Formula (I)) for in vivo delivery of therapeutic agents, such as nucleic acids. It is contemplated that these compounds are capable of highly effective in vivo delivery while maintaining a favorable toxicity profile.

To provide a method for extending the half-life of a T cell engager and improving its toxicity profile.SOLUTION: The method comprises a step of binding a half-life extending molecule-linked inhibitory peptide mask to a T cell engager via a cleavable linker, in order to produce a modified T cell engager having reduced toxicity in healthy tissue as compared to an unmodified T cell engager. The cleavable linker is cleaved in the tumor microenvironment. The half-life extending molecule-linked inhibitory peptide mask is released from the modified T cell engager in order to produce a cleaved T cell engager. The modified T cell engager has a longer half-life than both the unmodified T cell engager and the cleaved T cell engager.SELECTED DRAWING: Figure 11

This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering agents in vivo including nucleic acids and proteins. These compositions are not subject to accelerated blood clearance and they have an improved toxicity profile in vivo.

Herbal Anti-Inflammatory Compound Analyser with Toxicity Profiling Display Interface