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Flexible nanoliposomes with procyanidine and preparation method for flexible nanoliposomes

A nano-liposome and proanthocyanidin technology, applied in the field of medicine, can solve problems such as poor stability, easy drug leakage, and incomplete transdermal penetration

Inactive Publication Date: 2012-11-28
河南羚锐制药股份有限公司北京药物研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ordinary liposomes have disadvantages such as poor stabil

Method used

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  • Flexible nanoliposomes with procyanidine and preparation method for flexible nanoliposomes
  • Flexible nanoliposomes with procyanidine and preparation method for flexible nanoliposomes
  • Flexible nanoliposomes with procyanidine and preparation method for flexible nanoliposomes

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specific Embodiment approach 1

[0021] Specific embodiment one: the preparation method of proanthocyanidin flexible nano-liposome of the present embodiment is realized according to the following steps: one, the soybean lecithin of 0.1000-10.0000g and the sodium cholate of 0.0100-1.0000g are placed in the round bottom flask, then Add 5-100ml of mixed solvent of chloroform and methanol, ultrasonically dissolve, place in a water bath at 30-50°C, and rotate to form a film under the conditions of 0.04-0.09mPa and 20-70rpm; 2. Dissolve 0.0020-2.0000g of proanthocyanidins in Dissolve completely in 5-100ml of distilled water; 3. Add the drug solution into the prepared film, and hydrate by rotary evaporation at 30-50°C, 0.04-0.09mPa, 50-100rpm for 0.5-5h to obtain flexible nano-sized proanthocyanidins Liposomal suspension; 4. Put the obtained suspension in an ice-water bath for 1-20 minutes by probe-type ultrasonication, the power is 50w, the ultrasonic time and interval time are 4s, and the obtained suspension is fil...

specific Embodiment approach 2

[0022] Specific embodiment two: the difference between this embodiment and specific embodiment one is that the volume ratio of chloroform and methanol in step one is 1:1. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0023] Specific embodiment three: what this embodiment is different from specific embodiment two is that 0.9020g soybean lecithin and 0.1126g sodium cholate are placed in the round bottom flask in step one, then add the mixed solvent of 60ml of chloroform and methyl alcohol, ultrasonic Dissolve, place in a water bath at 30-50°C, and rotate to form a film under the conditions of 0.04-0.09mPa and 20-70rpm; in step 2, dissolve 0.0706g of proanthocyanidins in 60ml of distilled water to dissolve completely. Other steps and parameters are the same as in the second embodiment.

[0024] The encapsulation efficiency of the flexible proanthocyanidin nanoliposome obtained in this embodiment is 66.9%.

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Abstract

The invention belongs to the technical field of medicines, discloses flexible nanoliposomes with a procyanidine and a preparation method for the flexible nanoliposomes, solves the problem of the low in-vivo stability of the procyanidine, and optimizes the formula and preparation process of the flexible nanoliposomes with the procyanidine. The flexible nanoliposomes are prepared by the procyanidine and auxiliary materials such as phospholipid and a surfactant; the phospholipid serving as a membrane material can be on-sale commercial phospholipid and comprises natural phospholipid and synthesized phospholipid; the surfactant can be cholates and the like; the mass ratio of the phospholipid to the medicine is 5:1-50:1; the mass ratio of the phospholipid to the surfactant is 2:1-10:1; the probe ultrasonic time is 1 to 20min; and the preparation method is a film dispersion method. The flexible nanoliposomes prepared by the preparation method are relatively small in particle size, high in stability, simple, stable and feasible in preparation process and have a good transdermal function.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a flexible nano-liposome of proanthocyanidin, an antioxidant drug, and a preparation method thereof. Background technique [0002] Proanthocyanidins (abbreviated as PC), also known as condensed tannins, are polyphenolic compounds that widely exist in nature. They are widely distributed in the plant kingdom, and also exist in some beverages (tea, beer), vegetables, fruits and grains. Proanthocyanidins are a large class of polyphenolic compounds, which are easy to polymerize. According to the degree of polymerization, di-tetramers are usually called oligomers, and those above pentamers are called high polymers. [0003] Studies in recent years have shown that proanthocyanidins have the functions of scavenging free radicals, resisting ultraviolet damage, and resisting diseases and repelling insects. It is one of the most powerful natural antioxidants that humans have discovered from...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/353A61K8/14A61K8/49A61P39/06A61P17/16A61P33/00A61P43/00A61P29/00A61P37/08A61P9/00A61P35/00A61Q19/08
Inventor 熊维政张军斌武惠斌黄璐琦陈燕军熊欣袁军林顼佳音
Owner 河南羚锐制药股份有限公司北京药物研究院
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