Oryzanol liposome and its prepn

A technology of liposome and oryzanol, which is applied in the field of medicine, can solve the problems of low bioavailability, achieve the effect of improving curative effect and poor oral absorption

Inactive Publication Date: 2006-05-17
胡才忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oryzanol polylactic acid nanoparticle freeze-dried injection; bioavailability is low, and oryzanol is made into liposomes and proliposomes without recommendation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Preparation of oryzanol liposomes by ethanol injection method: take soybean lecithin, cholesterol, VE and add absolute ethanol to dissolve and inject into oryzanol aqueous solution, stir at constant temperature and high speed, evaporate under reduced pressure to remove ethanol, and pass through a microporous membrane to granulate to obtain oryzanol lipid body, the encapsulation efficiency can reach 60.8%.

Embodiment 2

[0012] Thin film dispersion method prepares oryzanol liposome: get soybean lecithin, cholesterol, VE is dissolved in 150ml eggplant-shaped bottle with 15ml chloroform, form a film under reduced pressure on a rotary thin film evaporator and remove all organic solvents, add 10ml oryzanol aqueous solution for hydration, The oryzanol liposomes are obtained by passing through a microporous membrane for whole grains, and the encapsulation efficiency can reach 59.1%.

Embodiment 3

[0014] Prepare oryzanol liposomes by reverse-phase evaporation: Weigh soybean lecithin, cholesterol, VE and add 5ml chloroform to dissolve, then add 10ml ether, then add 15ml oryzanol in phosphate buffer, bath ultrasonic to form a homogeneous single-phase system, Evaporate under reduced pressure to remove the chloroform ether until the gel is formed, continue to evaporate under reduced pressure for 5-10 minutes, and vortex until the aqueous suspension, that is, liposome, is formed. Encapsulation efficiency can reach 25.5%.

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PUM

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Abstract

The present invention is oryzanol liposome with high absorption, high bioavailability and high stability and its preparation. The oryzanol liposome or oryzanol liposome precursor is prepared with oryzanol and phosphatide, cholesterol, supporting agent and other supplementary material. It has phosphatide/medicine weight ratio of 0.1-40, and is prepared through ethanol injecting process, film dispersion process, inverse evaporation process, extruding process or mechanical process. The supporting agent may be sorbitol, mannitol, cane sugar, etc. and has ratio to phosphatide of 0.01-400. The oryzanol liposome can act selectively on the autonomic nerve system of interbran and the center of endocrine system to improve autonomic nerve system, endocrine system and psychonerve. It is suitable for treating neurosis, climacteric syndrome, etc., and may be used in the assisting treatment of vascular headache and cerebral concussion sequelae.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular it is an oryzanol liposome (including proliposome) and a preparation method thereof. Background technique [0002] Oryzanol (oryzanol) aliases: ferulic acid ester; r-orizanol; gammatsul; thiaminogen. It is separated from rice bran oil and is a mixture of ferulic acid esters mainly composed of triterpene alcohols. Selectively acting on the autonomic nervous system and the center of the endocrine system in the diencephalon can improve autonomic dysfunction, endocrine balance disorders and mental nervous disorders. For various neurosis, menopausal syndrome, premenstrual tension disorder, periodic psychosis, etc. It can also be used for adjuvant treatment of vascular headache and sequelae of concussion. Anti-inflammatory effect of γ-oryzanol Foreign Medicine. Chinese Medicine Volume 2004 03 He Yuzhuo Etc. g-oryzanol has anti-oxidation, anti-bacterial, anti-tumor and other pharmaco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61K9/127A61P15/00A61P15/12A61P25/00
Inventor 胡才忠
Owner 胡才忠
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