Compound cynanchum otophyllum oral preparation and preparation method thereof

An oral preparation, the technology of Qingyang ginseng, applied in the direction of pill delivery, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of large dosage, affecting absorption and utilization, and side effects, so as to improve absorption speed and reduce Toxic and side effects, the effect of simple preparation process

Inactive Publication Date: 2016-10-12
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commercially available Qingyangshen Tablets are recorded in the Ministry of Health of the People's Republic of China Drug Standards Traditional Chinese Medicine Prescription Volume 12 WS3-B-2343-97, which is a tablet made of Qingyangshen total glycosides and auxiliary starch. The tablet contains 100mg of total glycosides of Qingyangshen, and its usage and dosage is oral, 4-8 tablets at a time, 1 time at a time, and the dose is relatively large (400-800mg) each time, which will affect the patient's low compliance, and due to The dosage of medicine is large, which leads to the occurrence of some side effects; and the total saponins of Qingyang ginseng are poor in water solubility, and the dissolution rate of ordinary tablets is low (after testing, the dissolution rate is about 40%), which affects its absorption and utilization, and cannot meet the needs of clinical application.
So far, no report has been found on the use of total glucosides, gastrodin and pearl powder to make compound oral preparations, nor has there been any report on making the above active ingredients and carrier materials into solid dispersions and their preparations

Method used

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  • Compound cynanchum otophyllum oral preparation and preparation method thereof
  • Compound cynanchum otophyllum oral preparation and preparation method thereof
  • Compound cynanchum otophyllum oral preparation and preparation method thereof

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Effect test

Embodiment 1

[0097] The preparation of embodiment 1 solid dispersion

[0098] Active ingredients of compound Qingyang ginseng: Qingyang ginseng 160g, pearl powder 96g, gastrodin 40g

[0099] Preparation method: take the active ingredient of compound Qingyangshen and poloxamer 188 with a mass ratio of 1:4, first heat the carrier material in a water bath at 50°C, after the carrier material is completely melted, add the total glycosides of Qingyangshen, stir Evenly, quickly place it on an ice-water bath, stir quickly to solidify, then place the solidified product at -20°C for 4 hours, take it out, crush it, and dry it in vacuum for 24 hours, take it out, crush it, and pass through an 80-mesh sieve to obtain the compound Qingyang Active ingredient solid dispersion.

Embodiment 2

[0100] The preparation of embodiment 2 solid dispersion

[0101] Active ingredients of compound Qingyang ginseng: Qingyang ginseng 240g, pearl powder 144g, gastrodin 60g

[0102]Preparation method: take the active ingredient of compound Qingyang ginseng and polyoxyethylene 40 stearate at a mass ratio of 1:1, first heat the carrier material in a water bath at 60°C, and after the carrier material is completely melted, add Qingyang ginseng total Glycosides, stir evenly, quickly place on an ice-water bath, stir rapidly to solidify, then place the solidified product at -15°C for 4 hours, take it out, crush it, dry it in vacuum for 18 hours, take it out, crush it, pass through an 80-mesh sieve, and get Solid dispersion of active ingredients of compound Qingyang ginseng.

Embodiment 3

[0103] The preparation of embodiment 3 solid dispersion

[0104] Compound Qingyang ginseng active ingredients: Qingyang ginseng 200g, pearl powder 120g, gastrodin 50g

[0105] Preparation method: take the active ingredients of compound Qingyang ginseng and polyoxyethylene 40 stearate at a mass ratio of 1:2, first heat the carrier material in a water bath at 60°C, and after the carrier material is completely melted, add Qingyang ginseng total Glycosides, stir evenly, quickly place on an ice-water bath, stir quickly to solidify, then place the cured product at -10°C for 6 hours, take it out, crush it, dry it in vacuum for 24 hours, take it out, crush it, pass through an 80-mesh sieve, and get Solid dispersion of active ingredients of compound Qingyang ginseng.

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Abstract

The invention relates to an anti-epileptic sedative compound cynanchum otophyllum oral preparation and a preparation method thereof. The preparation method comprises the steps that by weight, 160-240 parts of cynanchum otophyllum total glycosides, 96-144 parts of pearl powder and 40-60 parts of gastrodin are mixed with other medical auxiliary materials to prepare the oral medicinal preparation according to the preparation technology. The compound cynanchum otophyllum oral preparation has the good effect when applied to treating epileptic and convulsive symptoms and achieving calming. Compared with existing cynanchum otophyllum sheets, rhizoma gastrodiae capsules and other products, the satisfying treatment effect can be achieved with a small dosage, the problems that cynanchum otophyllum total glycoside is poor in water solubility and an existing preparation is low in absorption and utilization degree, large in dosage and low in acting speed are solved, the compound cynanchum otophyllum oral preparation has the advantages of being stable, efficient, low in toxicity, high in acting speed and the like, and the preparation technology is simple and suitable for industrial production.

Description

technical field [0001] The invention relates to a compound Qingyangshen oral preparation and a preparation method thereof, belonging to the technical field of medicines. Background technique [0002] Epilepsy is one of the common diseases of the nervous system, second only to stroke in prevalence. The ratio of male to female in my country is 1.15:1 to 1.7:1. According to the type of clinical seizures, they are divided into generalized tonic-clonic seizures (major seizures), absence seizures (petit seizures), simple partial seizures, and complex partial seizures (psychomotor seizures). seizures), autonomic seizures (diencephalic), etc. Western medicine uses drugs such as diazepam, phenobarbital, sodium valproate, carbamazepine, and phenytoin according to the type of seizures. Proven prescriptions can be used for the treatment of epileptic grand mal seizures, etc., which can not only reduce the toxic and side effects of western medicine, but also take into account the beneficia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/27A61P25/08A61P25/20A61K35/618A61K31/7034
CPCA61K9/0053A61K9/1652A61K9/2059A61K9/4866A61K31/7034A61K35/618A61K36/27A61K2300/00
Inventor 钱一鑫康冀川何劲王鲁
Owner GUIZHOU UNIV
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