Cyclophosphamide liposome and its preparing method
A technology of cyclophosphamide lipid and cyclophosphamide, which is applied in the field of medicine, can solve the problem of high recurrence rate after surgery, and achieve the effect of improving curative effect and poor oral absorption
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Embodiment 1
[0010] Preparation of cyclophosphamide liposomes by ethanol injection method: take soybean phospholipids, cholesterol, VE and dissolve them in absolute ethanol and inject them into cyclophosphamide aqueous solution, stir at constant temperature and high speed, evaporate under reduced pressure to remove ethanol, pass through a microporous membrane for sizing, that is Cyclophosphamide liposomes were obtained, and the encapsulation efficiency could reach 66.8%.
Embodiment 2
[0012] Preparation of cyclophosphamide liposomes by thin film dispersion method: get soybean phospholipids, cholesterol, VE dissolved in 150ml eggplant-shaped bottle with 15ml chloroform, form a film under reduced pressure on a rotary thin film evaporator and remove all organic solvents, add 10ml cyclophosphamide The aqueous solution is hydrated, and the microporous membrane is passed through a microporous membrane to condense the particles to obtain cyclophosphamide liposomes, and the encapsulation efficiency can reach 63.1%.
Embodiment 3
[0014] Preparation of cyclophosphamide liposomes by reverse-phase evaporation method: Weigh soybean phospholipids, cholesterol, VE and add 5ml chloroform to dissolve, then add 10ml ether, then add 15ml cyclophosphamide phosphate buffer, bath ultrasonic to make uniform For single-phase system, remove chloroform ether by vacuum evaporation until gel is formed, continue to evaporate under reduced pressure for 5 to 10 minutes, and vortex until the aqueous suspension, that is, liposome, is formed. The encapsulation efficiency can reach 33.5%.
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