Notoginseng total saponin slow release preparation

A technology of panax notoginseng total saponins and slow-release preparations, which is applied to medical preparations containing active ingredients, cardiovascular system diseases, organic active ingredients, etc., and can solve the problem of low bioavailability of PNS oral preparations, affecting the labor force and economic growth , allergic reactions and other problems, to avoid drug side effects, improve bioavailability, and enhance the effect of efficacy

Inactive Publication Date: 2005-10-26
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This will create a heavy burden and affect the labor force population and economic growth
At present, due to the large toxic and side effects of western medicines, the patient's compliance with long-term use is poor, and Chinese people prefer traditional Chinese medicines.
Panax notoginseng and its preparations are favorite drugs for patients with cardiovascular diseases, but most of their preparations are traditional dosage forms with low curative effect and large dosage
These dosage forms all show problems such as poor patient compliance, adverse effects of allergic reactions and low curative effect.
Medical research shows that Panax notoginseng saponins have poor permeability in the gastrointestinal mucosa, the strong acidic environment of the stomach can degrade the drug, and the active monomers in it are easily metabolized by gastrointestinal enzymes and intestinal bacteria, which leads to The bioavailability of oral formulations of PNS is very low, where Rg 1 Bioavailability is 4.35%, Rb 1 It is 18.40%, and it is eliminated quickly in the blood

Method used

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  • Notoginseng total saponin slow release preparation
  • Notoginseng total saponin slow release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] According to the calculation of the preparation of 1000 tablets, take 70g of Panax notoginseng saponins, 30g of hypromellose, 0.2g of polyethylene glycol 4000, an appropriate amount of 95% medicinal alcohol, and 2g of magnesium stearate to make 1000 tablets in total. Specifications: Each tablet contains 70mg of Panax notoginseng saponins, and the theoretical tablet weight is about 102mg. The raw materials were passed through a 100-mesh sieve respectively, and the total saponins of Panax notoginseng and hypromellose were weighed according to the prescription and mixed evenly; 95% medicinal alcohol was used as a wetting agent to make soft materials, 24-mesh sieve was granulated, and vacuum dried at 60 ° C for 3 hours , 24-mesh sieve and granulated, add magnesium stearate and mix well, press with a 7mm punch to obtain the slow-release tablet of Panax notoginseng total saponins of the present invention. The 24-hour release rate was 75%.

Embodiment 2

[0030] According to the calculation of the preparation of 1000 tablets, take 60g of Panax notoginseng saponins, 40g of hypromellose, 0.4g of soluble starch, appropriate amount of 95% medicinal alcohol, and 2g of magnesium stearate to make a total of 1000 tablets. Tablet specifications: each The tablet contains 60 mg of Panax notoginseng saponins, and the theoretical tablet weight is about 102 mg. The raw materials were passed through a 100-mesh sieve respectively, and the total saponins of Panax notoginseng and hypromellose were weighed according to the prescription and mixed evenly; 95% medicinal alcohol was used as a wetting agent to make soft materials, 24-mesh sieve was granulated, and vacuum dried at 60 ° C for 3 hours , 24-mesh sieve and granulated, add magnesium stearate and mix well, press with a 7mm punch to obtain the slow-release tablet of Panax notoginseng total saponins of the present invention. The 24-hour release rate was 85%.

Embodiment 3

[0032] According to the calculation of the preparation of 1000 tablets, take 90 g of Panax notoginseng saponins, 5 g of hypromellose, 5 g of ethyl cellulose, 0.8 g of polyethylene glycol 4000, an appropriate amount of 95% medicinal alcohol, and 2 g of magnesium stearate. It is made into 1000 tablets, tablet specifications: each tablet contains 90 mg of Panax notoginseng saponins, and the theoretical tablet weight is about 102 mg. The raw materials were passed through a 100-mesh sieve respectively, and the total saponins of Panax notoginseng, hypromellose, and ethyl cellulose were weighed according to the prescription and mixed evenly; 95% medicinal alcohol was used as a wetting agent to make soft materials, and 24-mesh sieve was used to granulate at 60°C. Under vacuum drying for 3 hours, 24-mesh sieve for granulation, adding magnesium stearate and mixing, and pressing with a 7mm punch to obtain the Panax notoginseng total saponins sustained-release tablet of the present inventi...

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Abstract

A slow-releasing medicine in the form of capsule, tablet, or micropill for treating cardiovascular and cerebrovascular diseases is prepared from arasaponin, cellulose and hydrophilic additive.

Description

technical field [0001] The present invention relates to a sustained-release or interrupted-release pharmaceutical dosage form, in particular to a sustained-release preparation with saponins of panax notoginseng (PNS) as a single medicinal active ingredient. technical background [0002] According to the data released by the World Health Organization, among the causes of human death, cardiovascular and cerebrovascular diseases account for 39.4% of the total death population, ranking first; among human diseases, the recurrence rate of cardiovascular and cerebrovascular diseases is as high as 87%, ranking first. It ranks first; among human diseases, the disability rate of cardiovascular and cerebrovascular diseases is as high as 50%, ranking first. Cardiovascular and cerebrovascular diseases have become the number one killer of human health. With the development of the economy and the improvement of living standards, the Chinese people's lifestyle and dietary structure have un...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704
Inventor 王真刘萍
Owner YUNNAN BAIYAO GROUP
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