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Elemene transdermal agent and preparation method thereof

An elemene transdermal agent and elemene technology, applied in the field of medicine, can solve the problems of poor stability of elemene injection, poor oral absorption of elemene, low bioavailability, etc., so as to avoid the first-pass effect and improve the Therapeutic effect, the effect of stable blood concentration

Inactive Publication Date: 2011-06-01
HANGZHOU NORMAL UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of this invention is to provide a kind of elemene transdermal agent and preparation method thereof, to improve the poor oral absorption of elemene, low bioavailability; the defects of poor stability and local irritation of elemene injection, make it suitable for clinical application

Method used

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  • Elemene transdermal agent and preparation method thereof
  • Elemene transdermal agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Backing layer: non-woven fabric;

[0042] Lid lining: Polyester film.

[0043] The composition of each component of the medicated ointment is as follows by weight:

[0044] Elemene 3.0g Gelatin 3.0g Polyvinyl alcohol 4.2g Glycerin 2.8g Sodium polyacrylate 3.0g Menthol 0.1g Propylene glycol 4.6g Zinc oxide 2.5g Azone 0.8g Water Appropriate amount

[0045] Preparation method: Weigh the prescribed amount of gelatin, polyvinyl alcohol, and sodium polyacrylate, add appropriate amount of water, heat to make it swell completely, and stir to form a gel; add the prescribed amount of elemene, grind well, and then add glycerin , zinc oxide, propylene glycol, menthol and azone, grind for a certain period of time to make it uniform, and obtain the medicated ointment. Then spread it evenly on the non-woven fabric, dry it, cover it with a polyester film, and cut it into a suitable size.

Embodiment 2

[0047] Backing layer: non-woven fabric;

[0048] Lid lining: Polyester film.

[0049] The composition of the medicated ointment layer is as follows by weight:

[0050] Elemene 3.0g PVA 3.0g Azone 1.0g Propylene glycol 1.8g CMC-Na 0.6g Glycerin 1.2g Micropowder silica gel 0.5g Acrylic pressure sensitive adhesive 6.0ml Water Appropriate amount.

[0051] Preparation method: Weigh the prescribed amount of PVA, acrylate pressure-sensitive adhesive, and CMC-Na into a beaker, add an appropriate amount of water, heat to swell completely, and stir to form a gel. Add the prescribed amount of elemene, grind it evenly, then add glycerin, micronized silica gel, and azone, and grind it for a certain period of time to make it uniform, and then the medicated ointment is obtained. Then spread it evenly on the non-woven fabric, dry it, cover it with a polyester film, and cut it into a suitable size.

Embodiment 3

[0053] Backing layer: non-woven fabric;

[0054] Lid lining: Polyester film.

[0055] The composition of each component of the medicated ointment is as follows by weight:

[0056] Elemene 3.0g Glycerin 2.8g Sodium polyacrylate 3.0g Gelatin 3.0g Polyvinyl alcohol 4.2g Menthol 0.5g Lauryl alcohol 3.2g Zinc oxide 2.5g Oleic acid 0.5g Water Appropriate amount

[0057] Preparation method: Weigh the prescribed amount of gelatin, polyvinyl alcohol, and sodium polyacrylate, add appropriate amount of water, heat to make it swell completely, and stir to form a gel; add the prescribed amount of elemene, grind well, and then add glycerin , zinc oxide, oleic acid, menthol and lauryl alcohol, grind for a certain period of time to make it uniform, and obtain the medicated ointment. Then spread it evenly on the non-woven fabric, dry it, cover it with a polyester film, and cut it into a suitable size.

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Abstract

The invention belongs to the field of pharmaceutical, and relates to an elemene transdermal agent, which consists of three parts of a backing layer, a medicine containing ointment and a covering layer, wherein the medicine containing ointment is prepared from auxiliary materials such as elemene, a binder, a bulking agent, a transdermal promoter, a humectant and the like according to a certain blending ratio. The transdermal agent can continuously and stably release the medicines within the scheduled time, and the blood concentration is stable, thereby fundamentally eliminating the problems ofshort effective time, frequent administration and more untoward reactions existing in the prior formulations of the elemene medicines in aspect of treating cancers. The medicine containing ointment of the transdermal agent has good compatibility and adhesive capacity with skin, and the transdermal agent is good in stability. The method for preparing the transdermal agent is simple and convenient to operate.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an elemene transdermal agent and a preparation method thereof. Background technique [0002] Elemene (Elemene) is a natural medicine with anticancer activity extracted from the rhizome of Zingiberaceae plant Wenyujin (also known as Wenyujin) in my country. It is a new type of anticancer drug. Elemene is widely found in many kinds of traditional Chinese medicines, such as ginseng, Atractylodes macrocephala, cloves, chrysanthemum frondosa, chrysanthemum multispike, myrrh, windproof and other Chinese herbal medicines. Elemene chemical name: 1-methyl-1-vinyl-2,4-diisopropenylcyclohexane, molecular formula: C 15 h 24 . Elemene contains four isomers: α-elemene, β-elemene, γ-elemene and δ-elemene, and the main component is β-elemene. The preparation method of elemene has been reported in many literatures. It is generally extracted and refined from plants such as zedoary, or directl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/01A61P35/00
Inventor 吴学森谢恬范海珠
Owner HANGZHOU NORMAL UNIVERSITY
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