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Nanometer breviscapine polymer particle preparation and its preparation process

A technology of breviscapine and polymers, applied in the direction of drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of no product production methods, etc., achieve simple and easy operation, increase curative effect, and prolong cycle time Effect

Inactive Publication Date: 2011-01-19
珠海高新技术创业服务中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the above-mentioned technologies are still in the stage of exploration, and there are no products and mature production methods.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Get breviscapine 5g and polylactic acid 30g, dissolve completely in the mixed solution (2 / 3, v / v) of methanol and acetone of 15ml, then add it dropwise to the aqueous solution of 40ml poloxamer (its mass percentage concentration 3%), stirred at room temperature, completely removed the organic solvent, and then passed through a microporous membrane (0.45 μm) to obtain a scutellarin polymer nanoparticle suspension preparation, the average drug encapsulation efficiency of which was 88%, and the average The particle size is 100-250nm.

[0029] Ethanol and ethyl acetate were used instead of methanol to prepare scutellarin polymer nanoparticle suspension preparations according to the above method, and the average encapsulation rate of the drug was 87-90%, and the average particle size was 100-250nm.

[0030] Take 25, 60, and 100 g of polylactic acid respectively to prepare scutellarin polymer nanoparticle suspension preparation according to the above method. The average encap...

Embodiment 2

[0033] The poloxamer aqueous solution in Example 1 was replaced by the alkyl polyglycoside 0810 aqueous solution with a mass percentage concentration of 0.5%, 2.0%, and 4.0%, respectively, and the scutellarin polymer nanoparticle suspension was prepared according to the method described in Example 1. The preparation has an average drug encapsulation rate of 79-83%, and an average particle diameter of 150-350nm.

Embodiment 3

[0035] Mixtures of various poloxamers and alkyl polyglycosides 0810 were prepared at volume ratios of 1:1, 1:2, 1:3, 1:0.5, 1;0.3. Then take the above-mentioned mixture and add appropriate water respectively to form aqueous solutions with mass percentage concentrations of 0.5%, 2.0%, and 4.0% to replace the poloxamer aqueous solution in Example 1. The scutellarin polymer nanoparticle suspension preparation was prepared according to the method described in Example 1, the average encapsulation rate of the drug was 76-86%, and the average particle size was 100-400nm.

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PUM

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Abstract

The present invention relates to medicine, and is especially one kind of breviscapine-nanometer polymer preparation and its preparation process. The breviscapine-nanometer polymer preparation is prepared with breviscapine and nanometer polymer as carrier material in the weight ratio of 1 to 5-20. The breviscapine-nanometer polymer preparation has simple preparation process, and is applied clinically in treating cardiac and cerebral vascular diseases, such as cerebral thrombosis, cerebral infarction, coronary heart disease, etc.

Description

technical field [0001] The invention relates to a medicine and its preparation method and preparation, in particular to a scutellarin polymer nanoparticle preparation and its preparation method. Background technique [0002] Breviscapine is a flavonoid active ingredient extracted from the chrysanthemum breviscapus (Erigeronbreriscapus (vant) Hand mazz), which is a mixture of breviscapine mainly and a small amount of breviscapine. The chemical structure of scutellarin is 4,5,6-trihydroxyflavone-7-O-glucuronide. It has a significant effect on the treatment of cardiovascular and cerebrovascular diseases such as cerebral thrombosis, cerebral infarction, paralysis after stroke, coronary heart disease and angina pectoris. Pharmacological studies have shown that breviscapine can dilate cerebral blood vessels, improve the permeability of the blood-brain barrier, reduce cerebral vascular resistance, increase cerebral blood flow, improve microcirculation, and have the effect of resis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K47/34A61P9/10A61P7/02A61K47/10A61K47/36
Inventor 王义明罗国安刘明星刘清飞梁琼麟李卉芳
Owner 珠海高新技术创业服务中心
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