Liposome of Kudiezi and preparation method

A technology of liposome and Kudiezi, which is applied in the field of medicine, can solve the problems of low bioavailability, achieve the effect of improving curative effect and poor oral absorption

Inactive Publication Date: 2006-07-05
胡才忠
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Kudiezi polylactic acid nanoparticle lyophilized injection; bioavailability

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0009] Example 1:

[0010] Preparation of Kudiezi liposomes by ethanol injection method: take soybean phospholipid, cholesterol, VE and add anhydrous ethanol to dissolve the Kudiezi water solution, stir at constant temperature and high speed, evaporate under reduced pressure to remove ethanol, and granulate through microporous membrane to obtain bitter. The encapsulation efficiency of Dish Liposome can reach 81.8%.

Example Embodiment

[0011] Example 2:

[0012] Preparation of Kudiezi liposomes by thin film dispersion method: take soybean phospholipid, cholesterol, and VE, dissolve 15ml chloroform in a 150ml eggplant-shaped bottle, form a film under reduced pressure on a rotary thin film evaporator and remove all organic solvents, add 10ml Kudiezi water solution It is transformed and granulated through a microporous filter membrane to obtain Kudiezi liposomes with an encapsulation rate of up to 72.1%.

Example Embodiment

[0013] Example 3:

[0014] Preparation of Kudiezi liposomes by reversed-phase evaporation method: Weigh soybean phospholipid, cholesterol, VE and add 5ml chloroform to dissolve, then add 10ml ether, and then add 15ml Kudiezi's phosphate buffer, bath ultrasound to form a homogeneous single phase Evaporate the system under reduced pressure to remove the chloroform ether until the gel is formed, continue to evaporate under reduced pressure for 5-10 minutes, and vortex to form an aqueous suspension, namely liposomes. The encapsulation rate can reach 52.5%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

A lipid of sowthistleleaf ixeris herb for dilating coronary blood vessel, improving the blood oxygen supply and suppressing thrombosis and tumor is prepared proportionally from the sowthistleleaf ixeris herb, phosphatide, cholesterol and the supporting agent chosen from sorbitol, mannitol, sucrose, sodium chloride, water-soluble starch, etc by alcohol filling method, film dispersing method, reverse evaporation method, etc. Its advantages are high stability and high biologic utilization rate.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a Kudiezi liposome (including proliposome) and a preparation method thereof. Background technique [0002] Kudiezi is the annual dry whole herb of Compositae plant Ixerissonchifolia [Ixerissonchifolia (Bge.) Hance]. Also known as Gypsophila gypsophila, it is distributed in Northeast China and Inner Mongolia. It is rich in sources and low in price. It is often eaten as a wild vegetable among the people. Kudiezi is a plant of the Compositae family, Kudianzi, whose main components are adenosine and flavonoids including luteolin and apigenin. In recent years, with the gradual development of research on its chemical composition, pharmacological activity and clinical application, the pure Chinese medicine preparation made from the extract of Kudiezi has been used to treat coronary pneumonia through pharmacognosy, clinical pharmacology experimental research and clinical observation. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/28A61K9/127A61K9/16A61K9/20A61K9/48A61K9/19A61K9/08A61K9/10A61P9/10A61P7/02A61P35/00
Inventor 胡才忠
Owner 胡才忠
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap