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Liposome of Kudiezi and preparation method

A technology of liposome and Kudiezi, which is applied in the field of medicine, can solve the problems of low bioavailability, achieve the effect of improving curative effect and poor oral absorption

Inactive Publication Date: 2006-07-05
胡才忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Kudiezi polylactic acid nanoparticle lyophilized injection; bioavailability is low, but making Kudiezi into liposomes and proliposomes is not recommended

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Preparation of Kudiezi liposomes by ethanol injection method: Dissolve soybean lecithin, cholesterol, VE and anhydrous ethanol and inject it into Kudiezi aqueous solution, stir at constant temperature and high speed, evaporate under reduced pressure to remove ethanol, pass through a microporous membrane for sizing, and obtain Kudiezi liposomes. Dish liposomes, the encapsulation efficiency can reach 81.8%.

Embodiment 2

[0012] Preparation of Kudiezi liposomes by film dispersion method: take soybean lecithin, cholesterol, and VE and dissolve them in 150ml eggplant-shaped bottle with 15ml chloroform, form a film under reduced pressure on a rotary thin film evaporator and remove all organic solvents, add 10ml Kudiezi aqueous solution water and pass through a microporous membrane for whole grains to obtain Kudiezi liposomes, with an encapsulation efficiency of up to 72.1%.

Embodiment 3

[0014] Preparation of Kudiezi liposomes by reverse-phase evaporation: Weigh soybean lecithin, cholesterol, VE and add 5ml chloroform to dissolve, then add 10ml ether, then add 15ml Kudiezi phosphate buffer, bath ultrasonic to form a homogeneous single phase system, evaporated under reduced pressure to remove chloroform ether until the gel was formed, continued to evaporate under reduced pressure for 5 to 10 minutes, and vortexed until the aqueous suspension, that is, liposomes, formed. Encapsulation efficiency can reach 52.5%.

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PUM

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Abstract

A lipid of sowthistleleaf ixeris herb for dilating coronary blood vessel, improving the blood oxygen supply and suppressing thrombosis and tumor is prepared proportionally from the sowthistleleaf ixeris herb, phosphatide, cholesterol and the supporting agent chosen from sorbitol, mannitol, sucrose, sodium chloride, water-soluble starch, etc by alcohol filling method, film dispersing method, reverse evaporation method, etc. Its advantages are high stability and high biologic utilization rate.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a Kudiezi liposome (including proliposome) and a preparation method thereof. Background technique [0002] Kudiezi is the annual dry whole herb of Compositae plant Ixerissonchifolia [Ixerissonchifolia (Bge.) Hance]. Also known as Gypsophila gypsophila, it is distributed in Northeast China and Inner Mongolia. It is rich in sources and low in price. It is often eaten as a wild vegetable among the people. Kudiezi is a plant of the Compositae family, Kudianzi, whose main components are adenosine and flavonoids including luteolin and apigenin. In recent years, with the gradual development of research on its chemical composition, pharmacological activity and clinical application, the pure Chinese medicine preparation made from the extract of Kudiezi has been used to treat coronary pneumonia through pharmacognosy, clinical pharmacology experimental research and clinical observation. ...

Claims

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Application Information

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IPC IPC(8): A61K36/28A61K9/127A61K9/16A61K9/20A61K9/48A61K9/19A61K9/08A61K9/10A61P9/10A61P7/02A61P35/00
Inventor 胡才忠
Owner 胡才忠
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