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Medicinal composition for preventing and treating Alzheimer's disease and senility and preparation method thereof

A technology of Alzheimer's disease and drug compound, applied in the field of drug compound for preventing and treating Alzheimer's disease and aging and its preparation

Inactive Publication Date: 2010-11-17
SHANGHAI RIXIN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no research on the prevention and treatment of AD and aging by modulating blood thiamine concentration or / and thiamine-related protease activity at home and abroad.

Method used

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  • Medicinal composition for preventing and treating Alzheimer's disease and senility and preparation method thereof
  • Medicinal composition for preventing and treating Alzheimer's disease and senility and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] 1) According to the conventional method reported in the literature, prepare sulbutiamine tablet;

[0035] 2) By oral administration, a daily dose of 1 mg-1000 mg sulbutiamine was given to 6-month-old transgenic AD model mice or 12-month-old wild Kunming mice for 6 consecutive months;

[0036] 3) The mice in the sulbutiamine treatment group can significantly improve the cognitive function and prolong the average life expectancy of the mice. The results prove that sulbutiamine has the function of preventing and treating Alzheimer's disease and aging.

Embodiment 2

[0038] 1) According to the conventional method reported in the literature, the sulbutiamine aqueous injection was prepared;

[0039] 2) Administer 6-month-old transgenic AD model mice or 12-month-old wild Kunming mice by intraperitoneal administration for 6 consecutive months at a daily dose of 1 mg-1000 mg sulbutiamine;

[0040] 3) The mice in the sulbutiamine treatment group can significantly improve the cognitive function and prolong the average life expectancy of the mice. The results prove that sulbutiamine has the function of preventing and treating Alzheimer's disease and aging.

Embodiment 3

[0042] 1) According to the conventional method reported in the literature, the sulbutiamine aqueous injection was prepared;

[0043] 2) By spraying administration route, give 6-month-old transgenic AD model mice or 12-month-old wild Kunming mice a daily dose of 1 mg-1000 mg sulbutiamine for 6 consecutive months;

[0044] 3) The mice in the sulbutiamine treatment group can significantly improve the cognitive function and prolong the average life expectancy of the mice. The results prove that sulbutiamine has the function of preventing and treating Alzheimer's disease and aging.

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Abstract

The invention belongs to the technical field of biology, and relates to a medicinal composition for preventing and treating Alzheimer's disease and senility and a preparation method thereof. The medicinal composition contains sulbutiamine of different formulations and / or thioctic acid, carnitine, zinc sulfate, coenzyme Q10, vitamin B6, mecobalamin and / or folic acid. Integral animal experiments are performed by separately using the sulbutiamine of different formulations or using a combined formula with different components such as the sulbutiamine, thioctic acid, carnitine, zinc sulfate and the like, and the results prove that the medicinal composition can effectively defer the senility of wild aged mice and transgenic Alzheimer's disease mice, improve the cognitive function thereof, prolong the average expected service life and the like and has wide clinical application prospect.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to a drug compound for preventing and treating Alzheimer's disease and aging and a preparation method thereof. Background technique [0002] Alzheimer's disease (AD) is a chronic, age-related brain degenerative disease, mainly manifested by impairment of brain cognitive functions such as learning and memory. In European and American countries, 4%-12% of the elderly over 60 years old have dementia, and more than half of them are AD. Recent survey results show that the incidence of dementia in my country is close to that of European and American countries. There are more than 5 million elderly patients with dementia, of which AD accounts for 2 / 3. With the acceleration of population aging, the incidence and prevalence of AD will further increase, which will bring heavy mental and economic burdens to patients, families and society. [0003] At present, the exact pathogenesis of AD is still ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/30A61K31/51A61K31/675A61P25/28A61P39/06A61K31/122A61K31/205A61K31/385A61K31/4415A61K31/519A61K31/714
Inventor 钟春玖费国强潘晓黎
Owner SHANGHAI RIXIN BIOTECHNOLOGY CO LTD
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