41 results about "MTBI - Mild traumatic brain injury" patented technology

Disclosed herein are methods to treat cognition disorders, particularly those associated with aging. The method comprises administering a combination of a carnitine and an oxidant. Preferably the oxidant is thioctic acid. Preferably 0.12 grams to 3 grams of carnitine (particularly ALC) and 0.12 and 1.5 grams of R-alpha-lipoic acid are administered. Optionally, coenzyme Q and / or creatine also are administered. Preferably 10 mg to 500 mg / day of coenzyme Q10 and 1 to 30 grams / day of creatine are administered. The same method can be used to treat cognition deficits associated with carbon monoxide poisoning, mild traumatic brain injury, Type 2 diabetes mellitus, obsessive-compulsive disorder, environmental toxin exposure, and other conditions.

Cognitive assessment systems and methods that provide an integrated solution for evaluating the presence or absence of cognitive impairment. The present invention is used to test cognitive functions of an individual including information processing speed, working memory, work list learning and recall, along with variations of these tasks. Immersive and non-immersive systems and methods are disclosed. Testing and results feedback using the present invention may be completed in real time, typically in less than 15 minutes.

Cognitive assessment systems and methods that provide an integrated solution for evaluating the presence or absence of cognitive impairment. The present invention is used to test cognitive functions of an individual including information processing speed, working memory, work list learning and recall, along with variations of these tasks. Immersive and non-immersive systems and methods are disclosed. Testing and results feedback using the present invention may be completed in real time, typically in less than 15 minutes.

Compositions and methods for treating traumatic brain injury (TBI) and mild traumatic brain injury (mTBI) using progesterone and ent-progesterone are described.

A non-invasive system, and method for simple, quantitative screening for mTBI and other forms of mid cognitive impairment using a visuo-motor performance test (for example, a submaximal grip test) in response to visual feedback to quantitatively measure the intra-individual variability of performance metric for initial screening of patients with mild traumatic brain injury (mTBI), and other neurological disorders. The system and method can be administered in minutes, by any level of caregiver, in any environment including military in-the-field or sports on-field deployments, and is useful in screening those truly injured from those disguising or mimicking injury. In addition to screening, the system and method can be used to monitor and / or detect changes to intra-individual variability over time by comparison to a baseline, which in turn is helpful in determining estimated recovery trajectory or other related information.

The present disclosure provides systems and methods for evaluating a brain scan using reference data. Specifically, the systems and methods include a computed tomography (CT) scanner for the purpose of diagnosing concussions or mild traumatic brain injuries (mTBI). The system includes a multi-energy x-ray source (i.e., spectral CT), a photon counting x-ray detector, and a content-aware computer aided diagnostic (CAD) algorithm designed to detect imperceptible changes indicative of structural and physiological damage caused by a concussive event by comparing raw volumetric datasets of baseline (healthy) reference scan data to patient scan data taken after a concussive event.

A wireless system and methods for non-invasive detection of brain injury that includes a detection device for reliable monitoring and analyzing of sleep movement in comparison with normal sleep movement architecture to identify dampened sleep movement patterns indicative of brain injury.

Compositions and methods for treating traumatic brain injury (TBI) and mild traumatic brain injury (mTBI) using progesterone and ent-progesterone are described.

The disclosure provides for easy, reliable, and rapid screening of a mild traumatic brain injury (mTBI) based on a modeling of a subject's tracking of a dynamic target during the course of a simple motor tracking task. The gathered tracking data can be used to calculate tracking errors between the subject's actual input (e.g., grip force) and the intended target input. The tracking errors may be used to generate numerical values for model parameters that correlate the subject's responses to the tracking errors during the course of the dynamic motor tracking task. A classification model may be used to compare the model values to multi-subject model values of known diagnoses for mTBI. The entire screening process can be effectively administered in a matter of minutes or less, and with a high degree of accuracy.

Provided is a method of diagnosing and / or monitoring mild traumatic brain injury (mTBI) or concussion in a subject. The method comprises determining a level of at least one miRNA in a saliva sample from the subject. Also provided is a sensor element, a detection system, composition and a kit for diagnosing and / or monitoring TBI, and a method of determining an appropriate treatment for a subject with suspected mTBI or concussion.

A method and composition for reducing the recovery time for a human suffering from mild traumatic brain injury are provided. The composition is a mixture of component supplements that synergistically address the symptoms of the condition and the damage done by the injury.

An improved design for an athletic helmet incorporating non-Newtonian fluid shock absorbing structures.

The disclosure provides for easy, reliable, and rapid screening of a mild traumatic brain injury (mTBI) based on a modeling of a subject's tracking of a dynamic target during the course of a simple motor tracking task. The gathered tracking data can be used to calculate tracking errors between the subject's actual input (e.g., grip force) and the intended target input. The tracking errors may be used to generate numerical values for model parameters that correlate the subject's responses to the tracking errors during the course of the dynamic motor tracking task. A classification model may be used to compare the model values to multi-subject model values of known diagnoses for mTBI. The entire screening process can be effectively administered in a matter of minutes or less, and with a high degree of accuracy.

A method for testing a subject to detect a reduction in cerebral function presumably resulting from mild traumatic brain injury, that affects visual, proprioceptive, and vestibular brain functions includes: providing a user interface, input device, and portable computer into the hands of the test subject suspected of having mild traumatic brain injury; providing an icon on the user interface visible to the subject; rotating the subject holding the computer a predetermined number of revolutions, at a predetermined rate of rotation, to engage the vestibular system of the subject prior to testing; aligning, by the subject, the icon on the screen of the user interface in alignment with a test administrator; maintaining the alignment of the icon on the screen and the test administrator throughout the rotations; and conducting a real-time test for mild traumatic brain injury utilizing the user interface, the user input device, and the associated computer.

The present disclosure provides methods of maintaining brain function, memory function and reducing the prevalence of mild traumatic brain injury in an individual at risk of experiencing a mild traumatic brain injury. The present disclosure also provides methods for administering various human dietary supplements to individuals at risk of experiencing a mild traumatic brain injury.

The invention provides anti-UCH-L1 antibodies and anti-GFAP antibodies and their use in vitro detection of UCH-L1 and GFAP, respectively, in a sample from an individual, such as an individual known or suspected of having a brain injury or damage, for example, neurological damage such as mild traumatic brain injury. Also provided are methods, systems and kits for diagnosing brain injury or damage, such as neurological damage, in an individual with the aforementioned antibodies as well as compositions comprising the anti-UCH-L1 antibodies and anti-GFAP antibodies.

The present invention relates to a method of determining whether a subject has suffered a mild traumatic brain injury. The method comprises selecting a subject exposed to a head trauma and determining an apoA-1 level in a body fluid sample obtained from the selected subject, wherein a decreased apoA-1 level in the body fluid sample indicates that the subject has suffered a mild traumatic brain injury. The invention also relates to a kit for determining whether a subject has suffered a mild traumatic brain injury.

A system and method of identifying an impaired brain functionality such as a mild traumatic brain injury using speech analysis. In one example, recordings are taken on a device from athletes participating in a boxing tournament following each match. In one instance, vowel sounds are isolated from the recordings and acoustic features are extracted and used to train several one-class machine learning algorithms in order to predict whether an athlete is concussed.

Provided herein is a method of transfecting a brain cell of a subject with a polynucleotide comprising systemically administering to the subject a composition comprising a micelle having a hydrophobic superparamagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising the polynucleotide, wherein the subject has a mild traumatic brain injury.

A portable VOG device is disclosed that will facilitate the effective and efficient screening for TBI in military personnel in forward deployed military settings or remote locations using minimally trained staff. This includes the establishment of a protocol that will provide cost effective pre-screening of military personnel prior to deployment to establish a baseline of brain function prior to possible future injury. The efficiency of the device will promote subsequent follow-up screening to assess the effectiveness of prescribed TBI treatment. Further protocols for diagnosis and rehabilitation applications using the same virtual reality portable device will allow more advanced usage for clinicians providing ongoing evaluation and treatment.

An improved design for an athletic helmet incorporating non-Newtonian fluid shock absorbing structures.

The invention provides biomarkers and methods for determining the risk of a subject for developing mild traumatic brain injuries (mTBI). In some aspects, the methods of the invention also determine the fitness of a subject for participating in an activity with increased chances of receiving a head impact. Some embodiments of the invention are directed to kits for determining the risk of a subject for developing mTBI or the fitness of a subject for participating in an activity with increased chances of receiving a head impact.

The present disclosure provides systems and methods for evaluating a brain scan using reference data. Specifically, the systems and methods include a computed tomography (CT) scanner for the purpose of diagnosing concussions or mild traumatic brain injuries (mTBI). The system includes a multi-energy x-ray source (i.e., spectral CT), a photon counting x-ray detector, and a content-aware computer aided diagnostic (CAD) algorithm designed to detect imperceptible changes indicative of structural and physiological damage caused by a concussive event by comparing raw volumetric datasets of baseline (healthy) reference scan data to patient scan data taken after a concussive event.

A method for testing a subject to detect a reduction in cerebral function presumably resulting from mild traumatic brain injury, that affects visual, proprioceptive, and vestibular brain functions includes: providing a user interface, input device, and portable computer into the hands of the test subject suspected of having mild traumatic brain injury; providing an icon on the user interface visible to the subject; rotating the subject holding the computer a predetermined number of revolutions, at a predetermined rate of rotation, to engage the vestibular system of the subject prior to testing; aligning, by the subject, the icon on the screen of the user interface in alignment with a test administrator; maintaining the alignment of the icon on the screen and the test administrator throughout the rotations; and conducting a real-time test for mild traumatic brain injury utilizing the user interface, the user input device, and the associated computer.

Provided herein is a method of transfecting a brain cell of a subject with a polynucleotide comprising systemically administering to the subject a composition comprising a micelle having a hydrophobic superparamagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising the polynucleotide, wherein the subject has a mild traumatic brain injury.

Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate, severe, or moderate to severe traumatic brain injury (TBI), using cTnI. Also disclosed are methods for determining whether to perform a head computerized tomography on a subject by detecting levels of cTnI. Finally, alsodisclosed are methods of outcome in subjects suffering from a mild TBI.

The present disclosure provides a wearable device for the detection of mild traumatic brain injury, such as concussions, and methods of use thereof. Further disclosed are a method and system for detecting a mild traumatic brain injury.

Disclosed herein are methods that aid in the diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or a moderate, severe, or moderateto severe traumatic brain injury (TBI), by detecting levels of cardiac troponin I (cTnI) and one or more early biomarkers which are not cTnI, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1),glial fibrillary acidic protein (GFAP), or a combination thereof, in biological samples taken from a human subject at time points within about 24 hours of injury after the subject has sustained or may have sustained the injury to the head.