The invention discloses a method for realizing multidisciplinary and multi-objective optimization of a structural system of an automobile instrument panel, which is used in conceptual design and detailed design stages of the automobile instrument panel. In the method, the constitutive relation of a material is obtained based on a high-speed tensile test for a test specimen; on the basis of the constitutive relation, NVH (noise, vibration and harshness) performance analysis, service life prediction, head impact, knee pad impact and other discipline simulation analysis on the instrument panel structure are completed; based on a multidisciplinary coordinated optimization strategy, multidisciplinary cross analysis is carried out on the instrument panel system; and based on a radial basis function, a response surface method, a concurrent subspace method and a multi-objective genetic algorithm, multidisciplinary and multi-objective optimization design is carried out to obtain the Pareto optimal solution set of the instrument panel system, thus comprehensive optimization of performances of the automobile instrument panel such as structural lightweight, NVH performances, life prediction, passive safety and the like is realized so as to guide and realize efficient development and improved design of the instrument panel product.