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Coated thioctic acid tablet for treating and controlling diabetic neural lesion

A technology for neuropathy and coated tablets, which is applied in nervous system diseases, metabolic diseases, drug delivery, etc., can solve problems that do not involve composition prescriptions and formulations, and do not mention preparation methods, etc., to prolong storage time and facilitate Storage, avoiding the effect of inconvenience

Inactive Publication Date: 2006-03-01
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Found through document retrieval to prior art, U.S. Patent Publication No. is US5334612, and publication date is 19940802, and patent name is: PHARMACEUTICAL COMPOSITONS CONTAINING AS ACTIVESUBSTANCE SULPHUR-CONTAINING CARBOXYLIC ACID AND THEIR USE IN COMBATING RETROVIRUSES (sulfur-containing carboxylic acid as active ingredient Pharmaceutical composition and application in retroviral therapy), this patent discloses a pharmaceutical composition containing dimercapto carboxylic acid or dimercapto derivatives including lipoic acid and lipoic acid as active ingredients, and describes its use in the preparation of various The drug content of the preparations, and mentioned that some excipients that can be added to the preparations need to be added when preparing various types of preparations, but did not involve specific composition prescriptions and formulations, let alone specific preparation methods

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: the tablet core prescription of present example and proportioning are as follows (every thousand): lipoic acid 600g, lactose 78g, povidone 21g, microcrystalline cellulose 96g, croscarmellose sodium 24g, glue Stated silica gel 45g, magnesium stearate 36g, total tablet core 900g; coating prescription (per thousand tablets): hydroxypropyl methylcellulose 9.24g, sodium lauryl sulfate 1g, titanium dioxide 5.48g, Lemon yellow 0.11g, sunset yellow 0.04g, liquid paraffin 5.15g, total coating 21.02g.

[0019] This example uses fewer excipients for ease of administration; use film coating to protect from light. The prepared large-size lipoic acid-coated tablets use less excipients and are film-coated to avoid light, which prolongs the preservation time of the medicine and is convenient for storage. Due to the high content of the main drug, it is suitable for one-time oral administration, and the inconvenience of drug injection can be avoided.

Embodiment 2

[0020] Embodiment 2: the tablet core prescription of present example and proportioning are as follows (every thousand): lipoic acid 600g, lactose 60g, sodium hydroxymethyl cellulose 25g, microcrystalline cellulose 90g, crospovidone 25g, talcum Powder 50g, magnesium stearate 35g, total tablet core 885g; coating prescription (per thousand tablets): hydroxypropyl methylcellulose 9g, sodium lauryl sulfate 1g, titanium dioxide 5g, tartrazine 0.08g , carmine 0.02g, liquid paraffin 5g, total coating 20.10g.

[0021] This example uses fewer excipients for ease of administration; use film coating to protect from light. The prepared large-size lipoic acid-coated tablets use less excipients and are film-coated to avoid light, which prolongs the preservation time of the medicine and is convenient for storage. Due to the high content of the main drug, it is suitable for one-time oral administration, and the inconvenience of drug injection can be avoided.

Embodiment 3

[0022] Embodiment 3: the tablet core prescription of present example and proportioning are as follows (every thousand): lipoic acid 600g, lactose 70g, hypromellose 20g, microcrystalline cellulose 100g, croscarmellose sodium 20g , colloidal silica gel 45g, magnesium stearate 40g, total tablet core 895g; coating prescription (per thousand tablets): hydroxypropyl methylcellulose 10g, sodium lauryl sulfate 2g, titanium dioxide 6g, Sunset yellow 0.05g, carmine 0.15g, liquid paraffin 6g, total coating 24.20g.

[0023] This example uses fewer excipients for ease of administration; use film coating to protect from light. The prepared large-size lipoic acid-coated tablets use less excipients and are film-coated to avoid light, which prolongs the preservation time of the medicine and is convenient for storage. Due to the high content of the main drug, it is suitable for one-time oral administration, and the inconvenience of drug injection can be avoided.

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PUM

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Abstract

The present invention is coated thioctic acid tablet for treating and controlling diabetic neural lesion and belongs to the field of medicine technology. The tablet core consists of thioctic acid 600 mg, stuffing / diluent 150-180 mg, adhesive 20-25 mg, disintegrant 20-25 mg and lubricant 80-90 mg, and has total weight of 889.6-938.2 mg. The coating consists of skeleton / filming agent 10-12 mg, opacifier 5-6 mg, coloring agent 0.1-0.2 mg, surfactant 0.5-1 mg and plasticizer 5-6 mg, and has total weight of 20.10-24.20 mg. The present invention has less excipient for easy orally taking, film to screen light for long preservation period and high medicine content.

Description

technical field [0001] The invention relates to a tablet in the technical field of medicine, in particular to a lipoic acid-coated tablet for treating and controlling diabetic neuropathy. Background technique [0002] Alpha lipoic acid is a water-insoluble white or light yellow crystal widely distributed in biological tissues such as animals and plants. It was first isolated from pig liver by Reed et al. in the United States in 1950. It is widely used in clinical medicine in Europe and America, such as liver dysfunction, subacute necrotic encephalopathy, neurological diseases, radiation injury and other diseases. In the 1970s, Germany approved it as a drug for the treatment of hepatitis, and in the 1990s it was approved for the treatment of type II diabetes. The U.S. FDA approved lipoic acid as a health care product in 1997. Recent studies by German scientists have further confirmed that the combination of lipoic acid drugs and other drugs has a significant effect on the t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/385A61K9/36A61P3/10A61P25/00
Inventor 毛振民张剑亮
Owner SHANGHAI JIAO TONG UNIV
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