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Bismercapto compound modified water-soluble quantum dot and its preparation method

A bis-mercapto compound and quantum dot technology, which is applied in chemical instruments and methods, luminescent materials, etc., can solve the problems of poor stability of quantum dots, and achieve the effects of wide application range, easy realization, and simple operation

Inactive Publication Date: 2013-05-01
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the quantum dots prepared by the aqueous phase synthesis method usually have poor stability, which is also an important aspect that limits its application.

Method used

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  • Bismercapto compound modified water-soluble quantum dot and its preparation method
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  • Bismercapto compound modified water-soluble quantum dot and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] In parts by weight, the formula is as follows:

[0023] Monomethyl ether-capped polyethylene glycol (mPEG, molecular weight 1000) 20 parts

[0024] CdTe / CdS quantum dot solution (wavelength 580 nm, surface ligand is mercaptopropionic acid MPA) 150 parts

[0025] Preparation Process:

[0026] In parts by weight, 6 parts of lipoic acid (TA), 20 parts of monomethyl ether-capped polyethylene glycol (mPEG), and 1 part of p-dimethylaminopyridine (DMAP) were dissolved in 100 parts of dichloromethane. Then the mixed solution was reduced to 0 o C. Add 7 parts of N,N′-dicyclohexylcarbodiimide (DCC), keep warm for 1 hour, and react overnight at room temperature. After the reaction is over, first filter the reaction solution to remove insoluble matter, then evaporate the solvent by rotary evaporation, and add saturated NaHCO to the solid residue 3 50 parts of the solution, and then extracted three times with ethyl acetate. The ethyl acetate extracts were collected and drie...

Embodiment 2

[0037] In parts by weight, the formula is as follows:

[0038] Polyethylene glycol (PEG, molecular weight 3000) 60 parts

[0039] CdTe quantum dot solution (wavelength 545 nm, original surface ligand is thioglycolic acid TGA) 300 parts

[0040] Preparation Process:

[0041] In parts by weight, 6 parts of lipoic acid (TA), 60 parts of polyethylene glycol (PEG), and 1 part of p-dimethylaminopyridine (DMAP) are dissolved in 100 parts of dichloromethane. Then the mixed solution was reduced to 0 o C. Add 7 parts of N,N′-dicyclohexylcarbodiimide (DCC), keep warm for 1 hour, and react overnight at room temperature. After the reaction is over, first filter the reaction solution to remove insoluble matter, then evaporate the solvent by rotary evaporation, and add saturated NaHCO to the solid residue 3 50 parts of the solution, and then extracted three times with ethyl acetate. The ethyl acetate extracts were collected and dried over anhydrous sodium sulfate overnight. The sol...

Embodiment 3

[0052] In parts by weight, the formula is as follows:

[0053] Monocarboxyl-terminated polyethylene glycol (C-PEG, molecular weight 1000) 20 parts

[0054] CdTe / CdS / ZnS quantum dot solution (wavelength 625nm, original surface ligand is mercaptopropionic acid MPA) 500 parts

[0055] Preparation Process:

[0056] In parts by weight, 6 parts of lipoic acid (TA), 20 parts of monocarboxyl-terminated polyethylene glycol (C-PEG), and 1 part of p-dimethylaminopyridine (DMAP) were dissolved in 100 parts of dichloromethane. Then the mixed solution was reduced to 0 o C. Add 7 parts of N,N′-dicyclohexylcarbodiimide (DCC), keep warm for 1 hour, and react overnight at room temperature. After the reaction is over, first filter the reaction solution to remove insoluble matter, then evaporate the solvent by rotary evaporation, and add saturated NaHCO to the solid residue 3 50 parts of the solution, and then extracted three times with ethyl acetate. The ethyl acetate extracts were coll...

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Abstract

The invention relates to a bismercapto compound modified water-soluble quantum dot and its preparation method. The bismercapto compound modified water-soluble quantum point is prepared through connecting a bismercapto compound treating polyethylene glycol or its derivative as a basic skeleton with thioctic acid and reacting the bismercapto compound with a monomercapto group coated water-soluble quantum dot under the protection of nitrogen. The preparation method concretely comprises the following steps: carrying out an esterification reaction of the bismercapto compound treating polyethylene glycol or its derivative as a basic skeleton and thioctic acid, and carrying out ring opening to obtain a bismercapto ligand; and fully reacting the obtained ligand with the water-soluble quantum dot to obtain the stable bismercapto ligand modified water-soluble quantum dot. The bismercapto compound modified water-soluble quantum dot prepared through the method can be widely applied in the biological field, the medicinal field, the diagnosis field and the like.

Description

technical field [0001] The invention belongs to the field of preparation of nanomaterials, and relates to a water-soluble quantum dot and a preparation method thereof, in particular to a water-soluble quantum dot modified by a dithiol compound and a preparation method thereof, which are used to improve the stability of the water-soluble quantum dot . technical background [0002] Quantum dots (Quantum Dots, QDs) are a new type of semiconductor fluorescent material, which has the advantages of controllable wavelength, wide excitation spectrum, narrow emission spectrum, and good photostability. extensive attention of the audience. At present, high-quality fluorescent quantum dots are mostly synthesized by high-temperature oil phase method, the reagents are expensive and the operation is complicated, and the synthesized quantum dots can only be dispersed in organic solvents. Although water-soluble quantum dots can be obtained through the phase transfer method, severe fluoresc...

Claims

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Application Information

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IPC IPC(8): C09K11/02C09K11/88
Inventor 刘璐闫志强何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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