Anti-hair-loss composition, preparation thereof and application of anti-hair-loss composition in hair washing and caring products

Abstract

The invention discloses an anti-hair-loss composition, preparation thereof and application of the anti-hair-loss composition in hair washing and caring products, and belongs to the field of cosmetic preparation. The method for preparing the anti-hair-loss composition with the good and lasting anti-hair-loss effect comprises the following steps: (1) uniformly mixing arginine and citric acid, then adding diaminopyrimidine oxide, and continuously and uniformly mixing to form a mixture A; (2) uniformly mixing azelaic acid, nicotinamide and butanediol to form a mixture B; (3) uniformly mixing the mixture A, the mixture B, caffeine, a sanguisorba officinalis root extract, a green tea extract and a cacumen biotae extract to obtain the anti-hair loss composition. The anti-hair loss composition prepared by the invention is simple in component and simple in preparation process; the effect is lasting, and the anti-hair loss effect is good.

Description

Technical Field

[0001] The invention relates to an anti-hair loss composition and its preparation and application in hair washing and hair care products, belonging to the field of cosmetic preparation. Background Art

[0002] Hair loss can be divided into seborrheic alopecia and alopecia areata according to the mechanism of etiology; Seborrheic alopecia (SA), also known as male pattern baldness (MPA) and androgenic alopecia (AGA), is a progressive hair loss on the head, also known as male pattern baldness and androgenic alopecia. It is a common and frequently occurring disease in dermatology and one of the intractable diseases. Studies have shown that abnormal androgen levels are the main pathogenesis of seborrheic alopecia: testosterone in hair follicle cells is converted into dihydrotestosterone (DHT) by 5-reductase (5-AR), which causes hair follicle cells to enter the resting phase through a series of cell biochemical reactions, thereby causing terminal hair to transform into vellus hair, ultimately leading to hair loss.

[0003] There are a wide variety of anti-hair loss shampoos on the market, with varying effects. Traditional anti-hair loss shampoos achieve their anti-hair loss effects by adding chemical substances, but such shampoos are very likely to irritate the hair or skin, causing allergies, and therefore are difficult to meet the needs of the general public. As a result, some anti-hair loss compositions with traditional Chinese medicine components and plant extracts as the core have emerged.

[0004] The preparation methods of conventional anti-hair loss compositions generally involve the extraction and combination of Chinese herbs, such as:

[0005] CN116440207A discloses a method for preparing an anti-hair loss composition, which uses saffron, red ginseng and rhodiola rosea as main raw materials, and extracts effective ingredients through steps such as washing, drying, crushing, mixing, immersing in ethanol aqueous solution, eluting with a chromatography column, centrifugal treatment and evaporation; the advantage is that the natural ingredients of Chinese herbal medicine are used, but possible problems include extraction efficiency and stability, and dependence on the quality of raw materials;

[0006] CN112807400A discloses an anti-hair loss composition and a preparation method thereof, which comprises soaking raw materials such as Alpinia officinalis, Platycladus orientalis, turtle shell, amber, Perilla frutescens, agarwood, snake skin and the like with wine sweat, and then filtering to obtain the filtrate; this method is simple and easy to control, and is conducive to large-scale production, but may require a long soaking time and precise control of the raw material ratio;

[0007] CN106344442A discloses an anti-hair loss composition, which is a preparation of an anti-hair loss composition including ethanol, Platycladus orientalis leaf extract, Angelica sinensis extract and other components, which is completed by heating to dissolve, cooling to mix and filtering; this method uses supercritical extraction technology, which can better retain active ingredients, but may face the problem of high cost;

[0008] CN107019789A discloses a Chinese medicine composition for preventing hair loss and promoting hair growth, a preparation method thereof and an application thereof, wherein raw materials such as Platycladus orientalis leaves, Channa intestines, Sophora flavescens roots, Chuanxiong roots, Cnidium monnieri fruits, and Panax notoginseng roots are used; the composition is intended to promote scalp blood circulation and nutrient supply, activate hair follicles, and promote healthy hair growth; this method may require a deep understanding of the pharmacological effects of various raw materials, as well as precise proportions and extraction processes;

[0009] CN114224797A discloses an anti-hair loss and black hair essence and a preparation method thereof, a Chinese herbal medicine composition and a preparation method thereof, comprising the following components in parts by weight: 3-5 parts of angelica extract, 0.08-0.16 parts of Linderae umbellatae extract, 3-5 parts of saffron extract, 3-5 parts of black ganoderma extract, 3-5 parts of ginseng extract, 0.2-0.4 parts of nasturtium extract, 3-5 parts of Polygonum multiflorum extract, 3-5 parts of Chuanxiong extract, and 1-2 parts of pea extract; the anti-hair loss and black hair herbal medicine composition can improve the activity of tyrosinase and increase melanin synthesis, effectively promote the proliferation of hair follicle cells, and achieve the effects of tightening hair and darkening white hair, but the anti-hair loss effect of the composition is not significant;

[0010] CN103446563B discloses an anti-hair loss Chinese herbal medicine composition for inhibiting the activity of 5α-reductase, which is composed of the following components: saw palmetto extract, bayberry peel extract, Platycladus orientalis extract, angelica extract, Anemarrhena extract, Prunella vulgaris extract, ginger extract, Sophora flavescens extract, japanese apple extract, Schisandra chinensis fruit extract, Kaempferia galanga extract; the hair loss Chinese herbal medicine compound can be used to treat the symptoms of seborrheic alopecia caused by male androgen, but the Chinese herbal medicine composition contains multiple Chinese medicinal ingredients that are prone to allergic reactions, and the moisturizing effect on the scalp and hair follicles is not ideal.

[0011] It can be seen that the preparation methods of conventional anti-hair loss compositions are diverse, but basically they all require a lot of Chinese medicine compositions with complex ingredients; they have certain requirements for extraction; and the contact time with the scalp during use is relatively short, which makes it difficult for the active ingredients in the extract to fully exert their efficacy in a short period of time, resulting in the anti-hair loss effect being not significant. Summary of the invention

[0012] [Technical issues]

[0013] There are various preparation methods for conventional anti-hair loss compositions, but basically they all require a lot of Chinese medicine compositions with complex ingredients; they have certain requirements for extraction; and the contact time with the scalp during use is relatively short, which makes it difficult for the active ingredients in the extract to fully exert their efficacy in a short period of time, resulting in no significant anti-hair loss effect.

[0014] [Technical solution]

[0015] In order to solve the above problems, the present invention provides an anti-hair loss composition and its preparation and application in shampoo and hair care products. The anti-hair loss composition prepared by the present invention has simple ingredients and a simple preparation process; and has a long-lasting effect and a good anti-hair loss effect.

[0016] The first object of the present invention is to provide a method for improving the stability of diaminopyrimidine oxide, characterized in that the method comprises:

[0017] Arginine and citric acid are stirred and mixed at 40-55° C. and 500-1000 rpm for 20-60 min, and then diaminopyrimidine oxide is added and stirred and mixed at 40-55° C. and 500-1000 rpm for 20-60 min.

[0018] In one embodiment, the stability refers to that the diaminopyrimidine oxide in the product has good dispersibility, no precipitation, and no deterioration during normal storage.

[0019] The first object of the present invention is to provide a method for preparing a hair loss prevention composition having a good and long-lasting hair loss prevention effect, comprising the following steps:

[0020] (1) mixing arginine and citric acid uniformly, then adding diaminopyrimidine oxide, and continuing to mix uniformly to form a mixture A;

[0021] (2) mixing azelaic acid, niacinamide, and butylene glycol to form a mixture B;

[0022] (3) Mix the mixture A, the mixture B, caffeine, the Sanguisorba officinalis root extract, the green tea extract, and the Platycladus orientalis leaf extract to obtain an anti-hair loss composition.

[0023] In one embodiment of the present invention, the good anti-hair loss effect refers to the ability to improve hair loss symptoms; lasting means that during the long-term medication period (within 12 weeks), the hair loss symptoms will not deteriorate or even rebound; specifically, improving hair loss symptoms includes reducing hair loss counts, increasing local hair density, and increasing overall hair density.

[0024] In one embodiment of the present invention, the mass ratio of arginine, citric acid, diaminopyrimidine oxide, azelaic acid, niacinamide, butylene glycol, caffeine, Sanguisorba officinalis root extract, green tea extract, and Platycladus orientalis leaf extract is 0.1-0.3: 0.01-0.2: 1-2: 0.05-0.15: 0.2-0.6: 0.5-1.5: 0.2-0.4: 0.5-1.5: 0.4-0.8: 0.5-1.5.

[0025] In one embodiment of the present invention, the uniform mixing in step (1) is performed by stirring and mixing at 40-55° C. and 500-1000 rpm for 20-60 min; optionally, stirring and mixing for 30-60 min.

[0026] In one embodiment of the present invention, the mixing in step (1) is continued by stirring and mixing at 40-55° C. and 500-1000 rpm for 20-60 min; optionally, stirring and mixing for 30-60 min.

[0027] In one embodiment of the present invention, the uniform mixing in step (2) is performed by stirring and mixing at 80-100° C. and 500-1000 rpm for 20-90 min; optionally, stirring and mixing for 45-90 min.

[0028] In one embodiment of the present invention, the uniform mixing in step (3) is performed by stirring and mixing at 40-50° C. and 500-1000 rpm for 20-90 min; optionally, stirring and mixing for 45-90 min.

[0029] The second object of the present invention is the anti-hair loss composition prepared by the method of the present invention.

[0030] The third object of the present invention is to provide a method for preparing a hair care product with good and long-lasting anti-hair loss effect, comprising the following steps:

[0031] Firstly, the thickener and water are mixed evenly, and then the anti-hair loss composition and the preservative are added and mixed evenly to obtain a hair care product.

[0032] In one embodiment of the present invention, the mass ratio of the thickener, the anti-hair loss composition, the preservative and water is 0.2-1.2:5-10:0.4-0.8:90-100.

[0033] In one embodiment of the present invention, the thickener is a mixture of oligofructose and ammonium polyacryloyldimethyltaurate, and the mass ratio of the two is 5:4.

[0034] In one embodiment of the present invention, the preservative is a combination of phenoxyethanol and ethylhexylglycerin, and the mass ratio of the two is 9:1.

[0035] In one embodiment of the present invention, the uniform mixing is performed by stirring and mixing at 40-55° C. and 500-1000 rpm for 20-90 min.

[0036] In one embodiment of the present invention, the hair care product includes hair care essential oil, anti-hair loss essence and the like.

[0037] In one embodiment of the present invention, some essences, such as jasmine, rose, grass fragrance, etc., can be added to the hair care product.

[0038] The fourth object of the present invention is a hair care product prepared by the method of the present invention.

[0039] The fifth object of the present invention is the use of the anti-hair loss composition of the present invention in shampoo and hair care products.

[0040] In one embodiment of the present invention, the hair care products include hair care essential oils, anti-hair loss essences, conditioners, shampoos, and the like.

[0041] A sixth object of the present invention is to provide a method for improving the long-lasting anti-hair loss effect of hair care products, which uses the anti-hair loss composition or hair care product described in the present invention.

[0042] [Beneficial Effects]

[0043] (1) The present invention utilizes a combination of arginine and citric acid to form a dispersion stabilizer, thereby improving the stability of diaminopyrimidine oxide, so that the diaminopyrimidine oxide can better play an anti-hair loss role in the product.

[0044] (2) The present invention uses diaminopyrimidine oxide, azelaic acid, caffeine, Sanguisorba officinalis extract, green tea extract, and Platycladus orientalis leaf extract to cooperate with each other, and the anti-hair loss effect is more lasting and better.

[0045] (3) The composition of the present invention contains fewer types of plant extracts and Chinese herbal medicine extracts, is easy to operate, and is more suitable for industrialization.

[0046] Specifically, after 12 weeks of use, the anti-hair loss composition prepared by the present invention reduces the hair loss count by more than 51.07%, increases the local hair density by more than 11.4%, and increases the overall hair density by more than 17.8%, compared with not using it, which is significantly better than the anti-hair loss essence reported in the prior art CN117084950A. DETAILED DESCRIPTION

[0047] The preferred embodiments of the present invention are described below. It should be understood that the embodiments are for better explaining the present invention and are not used to limit the present invention.

[0048] Test method:

[0049] Test standards: hair loss counting, overall hair density assessment and local hair density assessment, see "Test Methods for Anti-Hair Loss Efficacy of Cosmetics";

[0050] According to the inclusion criteria, 100 patients with androgenic alopecia were randomly selected as subjects, including 70 males and 30 females (female androgenic alopecia); the age ranged from 20 to 50 years old, with an average age of onset of (33.4±10.7) years old, and the longest course of disease was 3 years and 2 months, the shortest was 3 months, and the average was 8 months;

[0051] 1. Eligibility criteria:

[0052] 1. Patients with androgenic alopecia aged 23-48 years old;

[0053] 2. Good health;

[0054] 3. Have not used hormones, immunosuppressants, hair growth drugs or other hair growth cosmetics recently;

[0055] 4. Those who have not participated in other clinical trials and voluntarily participate in this trial and complete the required contents;

[0056] 5. Fill out the informed consent form according to the requirements of the clinical trial.

[0057] 2. Exclusion conditions:

[0058] 1. Those who do not meet the selection criteria;

[0059] 2. Those who have ever been allergic to alcohol preparations or other hair growth products;

[0060] 3. Patients currently suffering from infectious or inflammatory diseases of the head or other skin diseases.

[0061] 3. Experimental Grouping:

[0062] A double-blind randomized paired group control was used. The evaluators were unaware of the details of the observed subjects, effects, grouping and sample dosage forms. There were an average of 10 people in each group.

[0063] 4. Usage:

[0064] Take 2ml and spray evenly on the head, once in the morning and once in the evening. Keep the hair dry before spraying.

[0065] V. Efficacy Criteria

[0066] 1. According to the data experimental analysis results, at any visit time point during the trial, there was no significant increase in hair loss counts before and after using the test product, or the difference in hair loss counts before and after was significantly lower than that of the control group (p < 0.05);

[0067] 2. There was no significant decrease in hair density or the difference in hair density before and after treatment was significantly higher than that in the control group (p<0.05).

[0068] 6. Stability test of anti-hair loss essence

[0069] The anti-hair loss essence (prepared in the examples and comparative examples) was sealed in a transparent bottle and placed under natural light at a temperature of 40° C. and a humidity of 50% for 12 months. Every 3 months, the bottle was observed for turbidity and precipitation, and the droplets after the sample was sprayed were observed to be uniform.

[0070] The raw materials used in the embodiments and comparative examples are:

[0071] Diaminopyrimidine oxide: 2,4-diaminopyrimidine-3-oxide, purchased from Pushan Industrial (Shaanxi) Co., Ltd., CAS: 74638-76-9;

[0072] Sanguisorba officinalis root extract was purchased from Sanyuan Tianyu Biological Products Co., Ltd., product specification 10:1;

[0073] Green tea extract: purchased from Shaanxi New Horizon Biotechnology Co., Ltd., tea polyphenols 89%, XTYLC98;

[0074] Platycladus orientalis leaf extract: purchased from Shaanxi New Horizon Biotechnology Co., Ltd., product specification 10:1;

[0075] Camellia oleifera seed extract: purchased from Weinan Dongjiang Tiancheng Industrial Co., Ltd., product specification 30:1.

[0076] Example 1

[0077] A method for preparing a hair loss prevention composition having good and long-lasting hair loss prevention effect comprises the following steps:

[0078] (1) arginine and citric acid were mixed, stirred at 50° C. and 800 rpm for 40 min, and then diaminopyrimidine oxide was added, and the mixture was continued to be stirred at 50° C. and 800 rpm for 30 min to form a mixture A;

[0079] (2) mixing azelaic acid, niacinamide, and butylene glycol, and stirring the mixture at 90° C. and 800 rpm for 40 min to form a mixture B;

[0080] (3) Mixing mixture A, mixture B, caffeine, Sanguisorba officinalis root extract, green tea extract, and Platycladus orientalis leaf extract, stirring and mixing at 50° C. and 800 rpm for 60 min to obtain an anti-hair loss composition;

[0081] Among them, the mass ratio of arginine, citric acid, diaminopyrimidine oxide, azelaic acid, niacinamide, butylene glycol, caffeine, Sanguisorba officinalis root extract, and green tea extract is 0.3:0.05:1.5:0.1:0.5:1:0.35:1:0.5:1.

[0082] Example 2

[0083] The mass ratio of arginine, citric acid, diaminopyrimidine oxide, azelaic acid, niacinamide, butylene glycol, caffeine, Sanguisorba officinalis root extract, and green tea extract in Example 1 was adjusted to 0.2:0.1:1.5:0.1:0.5:1:0.3:1:0.6:1, and the rest was kept consistent with Example 1 to obtain an anti-hair loss composition.

[0084] Example 3

[0085] The mass ratio of arginine, citric acid, diaminopyrimidine oxide, azelaic acid, niacinamide, butylene glycol, caffeine, Sanguisorba officinalis root extract, and green tea extract in Example 1 was adjusted to 0.1:0.1:1.5:0.1:0.5:1:0.5:1:0.8:1, and the rest was kept consistent with Example 1 to obtain an anti-hair loss composition.

[0086] Comparative Example 1

[0087] A method for preparing an anti-hair loss composition comprises the following steps:

[0088] (1) arginine, citric acid, and diaminopyrimidine oxide were mixed, and stirred at 50° C. and 800 rpm for 60 min to form a mixture A;

[0089] (2) mixing azelaic acid, niacinamide, and butylene glycol, and stirring the mixture at 90° C. and 800 rpm for 40 min to form a mixture B;

[0090] (3) Mixing mixture A, mixture B, caffeine, Sanguisorba officinalis root extract, green tea extract, and Platycladus orientalis leaf extract, stirring and mixing at 50° C. and 800 rpm for 60 min to obtain an anti-hair loss composition;

[0091] Among them, the mass ratio of arginine, citric acid, diaminopyrimidine oxide, azelaic acid, niacinamide, butylene glycol, caffeine, Sanguisorba officinalis root extract, green tea extract and Platycladus orientalis leaf extract is 0.3:0.05:1.5:0.1:0.5:1:0.35:1:0.5:1.

[0092] Comparative Example 2

[0093] A method for preparing an anti-hair loss composition comprises the following steps:

[0094] (1) arginine and citric acid were mixed, stirred at 50° C. and 800 rpm for 40 min, and then diaminopyrimidine oxide was added, and the mixture was continued to be stirred at 50° C. and 800 rpm for 30 min to form a mixture A;

[0095] (2) Mixing mixture A, azelaic acid, niacinamide, butylene glycol, caffeine, Sanguisorba officinalis root extract, green tea extract, and Platycladus orientalis leaf extract, stirring and mixing at 50° C. and 800 rpm for 60 min to obtain an anti-hair loss composition;

[0096] Among them, the mass ratio of arginine, citric acid, diaminopyrimidine oxide, azelaic acid, niacinamide, butylene glycol, caffeine, Sanguisorba officinalis root extract, and green tea extract is 0.3:0.05:1.5:0.1:0.5:1:0.35:1:0.5:1.

[0097] Comparative Example 3

[0098] A method for preparing an anti-hair loss composition comprises the following steps:

[0099] (1) arginine and citric acid were mixed, stirred at 50° C. and 800 rpm for 40 min, and then diaminopyrimidine oxide was added, and the mixture was continued to be stirred at 50° C. and 800 rpm for 30 min to form a mixture A;

[0100] (2) adding azelaic acid, niacinamide, and butylene glycol to mixture A, stirring and mixing at 90° C. and 800 rpm for 40 minutes to form a mixture;

[0101] (3) mixing the mixture, caffeine, Sanguisorba officinalis root extract, green tea extract, and Platycladus orientalis leaf extract, and stirring the mixture at 50° C. and 800 rpm for 60 min to obtain an anti-hair loss composition;

[0102] Among them, the mass ratio of arginine, citric acid, diaminopyrimidine oxide, azelaic acid, niacinamide, butylene glycol, caffeine, Sanguisorba officinalis root extract, green tea extract and Platycladus orientalis leaf extract is 0.3:0.05:1.5:0.1:0.5:1:0.35:1:0.5:1.

[0103] Comparative Example 4

[0104] A method for preparing an anti-hair loss composition comprises the following steps:

[0105] Arginine, citric acid, diaminopyrimidine oxide, azelaic acid, niacinamide, butylene glycol, caffeine, Sanguisorba officinalis root extract, green tea extract, and Platycladus orientalis leaf extract were mixed in a mass ratio of 0.3:0.05:1.5:0.1:0.5:1:0.35:1:0.5:1, and stirred at 50°C and 800 rpm for 120 minutes to obtain an anti-hair loss composition.

[0106] Comparative Example 5

[0107] The Sanguisorba officinalis root extract in Example 1 was omitted, and the other parts were kept the same as in Example 1 to obtain an anti-hair loss composition.

[0108] Comparative Example 6

[0109] The green tea extract in Example 1 was adjusted to camellia oleifera seed extract, and the other parts were kept consistent with Example 1 to obtain an anti-hair loss composition.

[0110] Comparative Example 7

[0111] The caffeine in Example 1 was adjusted to vitamin C, and the other ingredients were kept the same as in Example 1 to obtain an anti-hair loss composition.

[0112] Example 4

[0113] A method for preparing a hair loss prevention essence with good and long-lasting hair loss prevention effect comprises the following steps:

[0114] The thickener and water are mixed at 50° C. and 800 rpm, and stirred for 45 minutes, and then the anti-hair loss composition and the preservative are added, and mixed, and stirred for 45 minutes at 50° C. and 800 rpm to obtain an anti-hair loss essence;

[0115] The thickener is a mixture of oligofructose and ammonium polyacryloyldimethyltaurate, with a mass ratio of 5:4;

[0116] The preservative is a combination of phenoxyethanol and ethylhexylglycerin, with a mass ratio of 9:1;

[0117] The anti-hair loss composition is prepared by Examples 1-3 and Comparative Examples 1-7;

[0118] The mass ratio of the thickener, the anti-hair loss composition, the preservative and water is 1:8:0.6:90.

[0119] Comparative Example 8

[0120] The anti-hair loss essence was prepared using Example 1 of the applicant's previous patent CN 117084950 A.

[0121] The anti-hair loss essence prepared in Example 4 and the anti-hair loss essence prepared in Example 1 of patent CN 117084950 A (Comparative Example 8) were tested for anti-hair loss performance. The test results are as follows:

[0122] Table 1 Hair loss count

[0123] Observation period Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 8 0 Weeks 36.25 35.74 35.42 36.45 34.92 34.3 4 weeks 30.57 29.89 28.12 34.12 32.65 29.03 8 weeks 23.12 22.37 23.95 31.78 30.98 24.47 12 weeks 17.09 16.15 17.33 29.35 28.74 20.2 Observation period Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 0 Weeks 37.13 35.84 34.75 34.89 34.56 34.3 4 weeks 34.67 33.91 32.22 33.73 32.78 29.03 8 weeks 32.18 31.62 29.15 32.64 29.98 24.47 12 weeks 30.99 29.24 26.57 30.41 27.54 20.2

[0124] The results of hair loss counts are shown in Table 1. The results show that the anti-hair loss compositions prepared in Examples 1 to 3 have significant effects on alleviating hair loss at different observation periods, and are significantly better than different comparative examples 1 to 7 and the previous product (Comparative example 8). Among them, the hair loss counts of Examples 1 to 3 are reduced by more than 51.07 compared with no medication (0 week).

[0125] Table 2 Local hair density

[0126]

[0127]

[0128] The results of local hair density are shown in Table 2. The results show that the anti-hair loss compositions prepared in Examples 1 to 3 can significantly increase local hair density at different observation periods, and are significantly better than different comparative examples 1 to 7 and the previous product (Comparative Example 8). Among them, Examples 1 to 3 are increased by more than 11.4% compared with no medication (0 week).

[0129] Table 3 Overall hair density

[0130] Observation period Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Comparative Example 8 0 Weeks 3.52 3.71 3.56 3.82 3.70 3.95 4 weeks 3.88 4.01 3.82 3.87 3.76 4.06 8 weeks 4.15 4.25 4.11 3.88 3.84 4.17 12 weeks 4.33 4.37 4.27 3.95 3.83 4.18 Observation period Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 0 Weeks 3.67 3.91 3.75 3.67 3.55 3.95 4 weeks 3.74 3.99 3.85 3.71 3.72 4.06 8 weeks 3.79 3.93 3.93 3.85 3.88 4.17 12 weeks 3.77 4.09 4.01 3.92 4.11 4.18

[0131] The results of overall hair density are shown in Table 3. The results show that the anti-hair loss compositions prepared in Examples 1 to 3 can significantly improve the overall hair density at different observation periods, and are significantly better than different comparative examples 1 to 7 and the previous product (Comparative Example 8). Among them, Examples 1 to 3 are improved by more than 17.8% compared with no medication (0 week).

[0132] Table 4 Product stability

[0133]

[0134]

[0135] The storage stability results of the anti-hair loss essence are shown in Table 4. The results show that the anti-hair loss essence prepared in Examples 1 to 3 has good dispersibility and strong stability during daily storage, which is significantly better than the anti-hair loss essence obtained by changing the preparation steps in Comparative Examples 1 to 4.

[0136] Although the present invention has been disclosed as above in the form of a preferred embodiment, it is not intended to limit the present invention. Anyone familiar with this technology can make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, the scope of protection of the present invention should be based on the definition of the claims.

Claims

1. A method for improving the stability of diaminopyrimidine oxide, characterized in that: The method comprises: Arginine and citric acid are stirred and mixed at 40-55° C. and 500-1000 rpm for 20-60 min, and then diaminopyrimidine oxide is added and stirred and mixed at 40-55° C. and 500-1000 rpm for 20-60 min.

2. A method for preparing a hair loss prevention composition having a good and long-lasting hair loss prevention effect, characterized in that: The steps include: (1) mixing arginine and citric acid uniformly, then adding diaminopyrimidine oxide, and continuing to mix uniformly to form a mixture A; (2) mixing azelaic acid, niacinamide, and butylene glycol to form a mixture B; (3) Mix the mixture A, the mixture B, caffeine, the Sanguisorba officinalis root extract, the green tea extract, and the Platycladus orientalis leaf extract to obtain an anti-hair loss composition.

3. The method according to claim 2, characterized in that The mass ratio of arginine, citric acid, diaminopyrimidine oxide, azelaic acid, niacinamide, butylene glycol, caffeine, Sanguisorba officinalis root extract, green tea extract and Platycladus orientalis leaf extract is 0.1-0.3: 0.01-0.2: 1-2: 0.05-0.15: 0.2-0.6: 0.5-1.5: 0.2-0.4: 0.5-1.5: 0.4-0.8: 0.5-1.

5.

4. The method according to claim 2, characterized in that: In step (1), the uniform mixing is carried out by stirring and mixing at 40-55° C. and 500-1000 rpm for 20-60 min; and the uniform mixing is continued by stirring and mixing at 40-55° C. and 500-1000 rpm for 20-60 min.

5. The method according to claim 2, characterized in that: The uniform mixing in step (2) is carried out by stirring and mixing at 80-100° C. and 500-1000 rpm for 20-90 min; the uniform mixing in step (3) is carried out by stirring and mixing at 40-50° C. and 500-1000 rpm for 20-90 min.

6. The anti-hair loss composition prepared by the method according to any one of claims 2 to 5.

7. A method for preparing a hair care product with good and long-lasting anti-hair loss effect, characterized in that: The steps include: First, mix the thickener and water evenly, then add the anti-hair loss composition and preservative according to claim 6, mix evenly, and obtain a hair care product; wherein the mass ratio of the thickener, the anti-hair loss composition, the preservative, and water is 0.2-1.2:5-10:0.4-0.8:90-100.

8. The hair care product prepared by the method according to claim 7.

9. Use of the anti-hair loss composition according to claim 6 in shampoo and hair care products.

10. A method for improving the long-lasting anti-hair loss effect of hair care products, characterized in that: The anti-hair loss composition according to claim 6 or the hair care product according to claim 8 is used.

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