78 results about "Follicle growth" patented technology

The invention discloses a traditional Chinese medicinal hair growing fluid for treating alopecia seborrhoeica. The hair growing fluid comprises the following traditional Chinese medicinal raw materials in parts by weight: 90-110 parts of myrrh, 190-210 parts of asiatic bilberry leaf, 190-210 parts of folium artemisiae argyi, 190-210 parts of sweet wormwood herb, 140-160 parts of bunge corydalis herb, 190-210 parts of polygonum multiflorum, 190-210 parts of rhizoma cibotii, 190-210 parts of fructus psoraleae, 140-160 parts of drynaria total flavonoids, 190-210 parts of prepared rehmannia root, 140-160 parts of fructus rosae laevigatae, and 190-210 parts of astragalus membranaceus. The traditional Chinese medicinal hair growing fluid is prepared by grinding the raw materials into coarse powder according to the proportion, putting the coarse powder into a reaction kettle and decocting with 7 times amount of water to prepare the hair growing fluid. The traditional Chinese medicinal hair growing fluid has the effects of drying dampness, eliminating insects, disinfecting, killing mildew, resisting fungus and diminishing inflammation, has the functions nourishing blood and yin, replenishing essence and nourishing marrow, tonifying kidney and yang, dispelling blood to remove stasis, diminishing edema and promoting granulation, and promoting blood circulation, and can achieve the aims of eliminating chronic inflammation of hair follicle and scalp, killing lipophilic fungus and hair mite, clearing fomes in follicle, inhibiting over-secretion of androgen, and activating follicle growth.

The invention belongs to the technical field of biomedicines and particularly relates to a composition for improving premature ovarian failure, a preparation method therefor and application of the composition. According to the composition for improving the premature ovarian failure, provided by the invention, an in-vitro-constructed human uterine endometrium stem-cell cell membrane and a mesenchymal stem cell exosome are used in a compounded manner, thus, the development of ovarian follicles can be promoted, ovaries can be promoted to secrete an anti-Mullerian hormone, an ovarian follicle generator promoting level can be regulated, the apoptosis of ovarian cells can be inhibited, the adverse reserve function disease of the ovaries can be improved, the effect of improving primary or secondary premature ovarian failure is good, and thus, a new way of think is provided for clinically treating ovarian insufficiency and polycystic ovarian syndrome.

The invention provides 1ncRNA SFR1 as well as application thereof and a product and a method for regulating and controlling follicular development and relates to the technical field of biologics. Theinvention provides novel long-chain non-encoding RNA SFR1, wherein the 1ncRNA SFR1 is related to apoptosis of granular cells, and by regulating and controlling expression of 1ncRNA SFR1, correspondingregulation and control functions on channels, genes and hormones related to follicular development can be also achieved. Therefore, by adopting the 1ncRNA SFR1 and a corresponding product provided bythe invention, effective in-vivo / in-vitro regulation and control on follicular development can be achieved, and powerful guarantee can be provided for research on follicular development and physiology and biochemical functions. In addition, through the regulation and control functions of the 1ncRNA SFR1 on follicular development, the population fertility can be improved while excellent propertiesof genetic resources of mammals, particularly sheep, are maintained, and thus the economic benefits of breeding can be increased.

The invention provides an application of miRNA as a biomarker to prediction of IVF-ET outcome, and belongs to the technical field of biomedicines. According to the invention, a series of bioinformatics analysis tools are utilized to predict some candidate miRNAs which are used for targeted regulation of BDNF and are related to follicular development. FFs from mature follicles ( greater than 18 mm)or immature follicles smaller than 15 mm) are then collected, and whether the expression of the miRNAs is negatively correlated to the expression of the BDNF is evaluated. Finally, whether the miRNAscan become potential biomarkers for predicting the IVF-ET outcome or not is further researched. Therefore, two miRNAs, namely miR-103a-3p and miR-10a-5p, are finally screened out, the expression level of the miRNAs in the FF around specific oocyte can predict the outcome of the subsequent IVF treatment of the oocyte, and good practical application value is achieved.

Methods are provided for activating dormant ovarian primordial follicles in a mammal to promote development to preovulatory follicles.

A method of treating infertility disorders by 1) administering an LH-RH antagonist, preferably Cetrorelix, in amounts to selectively suppress endogenous LH but not FSH secretion and 2) inducing follicle growth by administration of exogenous gonadotropin. The selective suppression OF LH allows FSH secretion to be at natural levelS thereby not affecting individual estrogen development. The LH-RH antagonist can be given as a single or dual subcutaneous dose in the range of 1 mg to 10 mg, preferably 2 mg-6 mg. In multiple dosing-posology, LH-RH antagonist can be administered subcutaneously in an amount in the range of 0.1 to 0.5 mg of LH-RH antagonist / day. LH-RH antagonist is applied starting cycle day 1 to 10, preferably on day 4 to 8, and ovulation can be induced between day 9 and 20 of the menstruation cycle by administering rec. LH, native LH-RH, LH-RH agonist or by HCG. In addition rec. LH, native LH-RH or LH-RH agonist can be given to avoid hyperstimulation syndrome and native LH-RH or a LH-RH agonist can be administered to avoid luteal phase stimulation by neutralizing the negative effects of HCG.

The invention belongs to the technical field of cosmetics, and discloses a silicon oil free shampoo capable of preventing alopecia. The shampoo is prepared from the following raw materials in parts by weight: 9-13 parts of dodecyl polyglucoside, 4-9 parts of sodium olivoyl glutamate, 1-5 parts of coconut oil monoisopropanolamine, 0.5-2.5 parts of polyquaternary ammonium salt-10, 0.1-0.9 part of guar hydroxypropyltrimonium chloride, 1-4 parts of raspberry seed oil, 2-5 parts of a poterium officinale root extract, 0.1-0.6 part of a pyrus cydonia extract, 2-6 parts of a paniculate swallowwort root extract, 0.2-0.7 part of citric acid, 0.1-0.5 part of ethylenediaminetetraacetic acid, 0.1-0.4 part of hydroxypropyl methyl cellulose, 0.1-0.3 part of kathon, 0.2-0.5 part of essence and 40-60 parts of water. The shampoo provided by the invention, when used for cleaning hair, can stimulate follicle growth and activate scalp cells, and in addition, the shampoo can enhance blood circulation in scalp; the shampoo has functions of promoting circulation of blood and qi, treating alopecia and controlling oil; and specifically, the shampoo has a significant curative effect on seborrheic alopecia.

The invention discloses a serum-free culture solution for in-vitro culture of sheep ovarian cortex tissue. The culture solution comprises a basic culture solution and an additive, wherein the basic culture medium is a mixed solution of alpha-MEM and DMEM; the additive comprises the following components: 3-10 micrograms / mL bovine serum albumin, 0.10-0.50mM sodium pyruvate, 1-5mM glutamine, 1-5mM hypoxanthine, 3-10 micrograms / mL insulin, 1-5 micrograms / mL transferrin, 2-8 nanograms / mL sodium selenite, 10-200 micrograms / mL VC, 50-200IU / mL penicillin and 50-200IU / mL streptomycin, and the pH valueis 6.9-7.5. Through the synergistic effect of the components, the proliferation speed of interstitial cells is inhibited, the proliferation of granular cells is promoted, the defect that the three-dimensional environment of original follicle development cannot be maintained due to tissue collapse caused by excessive proliferation of the interstitial cells in the culture process of the ovarian cortex tissue is overcome, the growth and development condition and survival time of original follicles in the ovarian cortex tissue in vitro are effectively improved, meanwhile, the influence of unknowncomponents in serum on research is avoided, and the serum-free culture solution has a good application prospect.

The present technology provides for methods for generation and isolation of granulosa cells and / or granulosa cell precursors from multi-potent cells, wherein the granulosa cells and / or granulosa cell precursors are useful in methods for growth and maturation of follicles or follicle-like structures. Additionally, the present technology also provides for methods of increasing steroidal hormones in a subject in need thereof.