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Application of nicotinic acid derivates in preparation of medicaments for promoting follicular development and maintaining ovarian functions

A technology of derivatives and acids, applied in the field of nicotinic acid derivatives

Active Publication Date: 2012-03-28
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current treatments cannot fundamentally change ovulation disorders, only hormone regulation

Method used

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  • Application of nicotinic acid derivates in preparation of medicaments for promoting follicular development and maintaining ovarian functions
  • Application of nicotinic acid derivates in preparation of medicaments for promoting follicular development and maintaining ovarian functions
  • Application of nicotinic acid derivates in preparation of medicaments for promoting follicular development and maintaining ovarian functions

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Experimental program
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Effect test

Embodiment Construction

[0054] Experimental materials: Niacin, inositol nicotinate and nicotinamide used in the implementation were purchased from Sigma Reagent Company, cell culture grade. Oral niacin and niacinamide are available from pharmacies. Cyclophosphamide was obtained from the hospital. Niacinamide intravenous injection liquid, dissolved in normal saline, configured to 10mg / ml. The concentration of niacin solution is 16mg / ml. The concentration of inositol nicotinic acid lipid solution is 20mg / ml. Cyclophosphamide was formulated with physiological saline to 100mg / ml.

[0055] Experimental animals: 100 healthy female Kunming white mice, aged 6 weeks, were raised at a temperature of 23°C to 25°C, a relative humidity of 50-60%, free access to food and water, and 12 hours of light per day for adaptive feeding.

[0056]Experimental method: After one week of adaptive feeding, the animals were divided into 5 groups on average, namely blank control group, model group, nicotinic acid group, nicot...

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Abstract

The invention discloses application of nicotinic acid derivates in the preparation of medicaments for promoting follicular development and maintaining ovarian functions. Experiment proves that the nicotinic acid derivates can promote follicular growth in the ovary, promote hormonogenesis and endometrial growth and enable women to form a regular period. The derivates have special treatment effects on promoting follicular development and maturing, treating ovarian hypofunction, recovering period and reducing climacteric symptoms. The invention compensates for the defects of the existing medicaments, and provides a new method for treating ovarian diseases, which is high in efficiency, convenient to use and low in cost.

Description

technical field [0001] The invention relates to a nicotinic acid derivative, in particular to the use of the nicotinic acid derivative in the preparation of drugs for treating ovarian function diseases. Background technique [0002] The ovary is one of the most important organs of human women, and it is the place where oocytes are stored. The state of the ovary directly determines the fertility of women. All eggs in the ovary exist in the form of quiescent primordial follicles or growing primary and secondary follicles. Ovarian failure, dormant follicles that cannot be activated and re-enter growth will lead to loss of fertility. Premature ovarian failure also affects the secretion of progesterone and estrogen by the ovary, which affects sexual function and directly leads to aging of women. There have been studies in foreign countries to restore menopausal women's menstrual cycle after transplanting young ovaries. It can be seen that the function of ovaries has a great rela...

Claims

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Application Information

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IPC IPC(8): A61K31/455A61P15/08
Inventor 王淑芳姚元庆
Owner GENERAL HOSPITAL OF PLA
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