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Medicine for treating anovulatory infertility

A drug and obstacle technology, applied in the field of drugs for treating infertility caused by ovulation disorder, can solve the problems of oocyte retrieval puncture injury and bleeding, uncertainty of curative effect, influence harmony, etc. good ovulation effect

Inactive Publication Date: 2020-08-25
河南省中医药研究院附属医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The incidence of infertility in my country is 7% to 10%, among which the infertility patients caused by ovulation disorder are more, reaching 25-30%. Infertility will bring many problems in life to married women. Serious It will affect the harmony of the family. There is uncertainty in the curative effect of Western medicine in the treatment of ovulatory infertility, and there are obvious side effects, such as: (1) ovarian hyperstimulation syndrome; (2) egg retrieval puncture and laparoscopic surgery It can cause damage and bleeding of egg retrieval puncture, anesthesia accident, pneumothorax and mediastinal emphysema, thrombus, large blood vessel injury, etc.; (3) spontaneous abortion, multiple pregnancy; (4) induced ovulation has the potential risk of cancer, such as breast cancer , reproductive tract cancer, and hormone-derived cancers such as melanoma, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1: A medicine for treating ovulation disorder, including Bushen Tonifying Formula and Luteinizing Formula.

[0030] The kidney-tonifying and essence-reinforcing prescription includes the following ingredients, each prescription is: Rehmannia glutinosa 15-24g, raw yam 15-30g, cornus 12-18g, medlar 15-20g, fairy spleen 15-30g, Cuscuta 15-30g, vinegar turtle 9-12g, Tian Dayun 12-24g, antler cream 9-12g, angelica 12-18g, fried white peony 9-15g, fried Atractylodes 9-15g, gallinacea 6-12g. The luteinizing prescription includes the following raw material components, each prescription is: Rehmannia glutinosa 10-20g, yam 15-30g, medlar 12-20g, dodder 15-30g, astragalus 15-30g, Codonopsis 10-20g, fried Atractylodes macrocephala 9-15g, Chuanduan 10-15g, Sangjisheng 10-15g, Scutellaria baicalensis 9-15g, Sugeng 9-12g, Amomum 4-6g (below).

[0031] Tonifying kidney and replenishing essence formula is taken on the 5th day of menstruation, taken for 7 days or until the dr...

Embodiment 2

[0032] Embodiment 2: A kind of medicine for treating ovulation disorder, including kidney-tonifying and blood-activating formula and luteinizing formula, described kidney-tonifying and blood-activating formula includes the following raw material components, and each dose of formula is: Rehmannia glutinosa 15-20g, Chinese yam 15-30g, Lycium barbarum 9-15g, Guizhi 9-12g, Radix Paeoniae Rubra 9-15g, Peach kernel 9-12g, Cuscuta 15-30g, Cuscuta 15-30g, Xianlingpi 15-30g, Gallus gallus 9-12g. The luteinizing prescription includes the following raw material components, each prescription is: Rehmannia glutinosa 10-20g, yam 15-30g, medlar 12-20g, dodder 15-30g, astragalus 15-30g, Codonopsis 10-20g, fried Atractylodes macrocephala 9-15g, Chuanduan 10-15g, Sangjisheng 10-15g, Scutellaria baicalensis 9-15g, Sugeng 9-12g, Amomum 4-6g (below).

[0033] Tonifying kidney and activating blood formula is taken in the later stage of follicles when the diameter of the follicle reaches 13mm. After...

Embodiment 3

[0034] Embodiment 3: A medicine for treating ovulation disorder, including the formula of nourishing kidney and nourishing essence, formula of nourishing kidney and promoting blood circulation and formula of stimulating lutein.

[0035] The kidney-tonifying and essence-reinforcing prescription includes the following ingredients, each prescription is: Rehmannia glutinosa 15-24g, raw yam 15-30g, cornus 12-18g, medlar 15-20g, fairy spleen 15-30g, Cuscuta 15-30g, vinegar turtle 9-12g, Tian Dayun 12-24g, antler cream 9-12g, angelica 12-18g, fried white peony 9-15g, fried Atractylodes 9-15g, gallinacea 6-12g.

[0036] The prescription for invigorating the kidney and activating blood includes the following raw material components, each prescription is: 15-20g rehmannia glutinosa, 15-30g Chinese yam, 9-15g medlar, 9-12g cassia twig, 9-15g red peony root, 9-12g peach kernel , Cuscuta 15-30g, Cuscuta 15-30g, Xianlingpi 15-30g, Chicken Gold 9-12g.

[0037] The luteinizing prescription i...

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicines, and provides a traditional Chinese medicine preparation for treating infertility caused by ovulation failure. The traditional Chinese medicine preparation mainly comprises a formula capable of invigorating the kidney and replenishing essence, a formula capable of reinforcing the kidney and activating blood, and a formula capableof accelerating corpus luteum, wherein the formula capable of invigorating the kidney and replenishing essence comprises the following raw material ingredients: 15-24 g of radix rehmanniae praeparata,15-30 g of rhizoma dioscoreae, 12-18 g of fructus corni, 15-20 g of fructus lycii, 15-30 g of herba epimedii, 15-30 g of semen cuscutae, 9-12 g of vinegar-processed testudinis carapax, 12-24 g of herba cistanches, 9-12 g of cornu cervi degelatinatum, 12-18 g of radix angelicae sinensis, 9-15 g of parched paeoniae alba radix, 9-15 g of parched atractylodis macrocephalae rhizome and 6-12 g of endothelium corneum gigeriae galli. According to a rule of mutual transformation between yin and yang as well as qi and blood replenishment and deficiency change during each period of menstruation, follicle development and ovulation can be accelerated, the ovulation rate and the pregnancy rate of the anovulatory infertility can be improved, a clinical curative effect is exact, a pregnancy rate is high,and an ovulation failure problem is solved fundamentally.

Description

technical field [0001] The invention relates to a medicine, especially a medicine for treating infertility caused by ovulation disorder. Background technique [0002] The incidence of infertility in my country is 7% to 10%, among which the infertility patients caused by ovulation disorder are more, reaching 25-30%. Infertility will bring many problems in life to married women. Serious It will affect the harmony of the family. There is uncertainty in the curative effect of Western medicine in the treatment of ovulatory infertility, and there are obvious side effects, such as: (1) ovarian hyperstimulation syndrome; (2) egg retrieval puncture and laparoscopic surgery It can cause damage and bleeding of egg retrieval puncture, anesthesia accident, pneumothorax and mediastinal emphysema, thrombus, large blood vessel injury, etc.; (3) spontaneous abortion, multiple pregnancy; (4) induced ovulation has the potential risk of cancer, such as breast cancer , reproductive tract cancer, a...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K36/9064A61P15/08A61K35/32A61K35/57A61K35/586
CPCA61K35/32A61K35/57A61K35/586A61K36/185A61K36/232A61K36/284A61K36/296A61K36/344A61K36/39A61K36/40A61K36/43A61K36/481A61K36/533A61K36/535A61K36/539A61K36/54A61K36/64A61K36/65A61K36/71A61K36/736A61K36/804A61K36/815A61K36/8945A61K36/9064A61P15/08A61K2300/00
Inventor 王希浩宗利平张爱华赵嘉梅杨程程
Owner 河南省中医药研究院附属医院
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