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A Chinese medicinal membrane agent capable of being dissolved rapidly in oral cavity and preparation method thereof

A technology of film preparation and traditional Chinese medicine, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug combinations, etc.

Inactive Publication Date: 2006-11-22
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Above-mentioned these traditional Chinese medicines have shown better curative effect aspect treatment angina pectoris, migraine, but the traditional Chinese medicine compound prescription or single flavor medicine of treating coronary heart disease, angina pectoris, migraine at present mostly are tablet granule, capsule, soft capsule, injection, drop. Dosage forms such as pills, new dosage forms for emergencies, and thin films that dissolve quickly in the mouth are still under development, and there are no reports in the literature

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Coronary miltiorrhiza extract 3.0g, 2.0gHPC, 5.0g polyvinylpyrrolidone, 0.02g stevioside, 0.3g glycerin, be dissolved in the ethanol of 12ml95%, form a solution, this solution is smeared on the silicon rubber paper with squeegee, The formed film of 350 microns was dried at 35°C for 30 minutes, and continued to be dried at 60°C for 30 minutes, with a plane weight of 80g / m 2 Next, form a film with a thickness of 90 microns, carefully remove it from the silicone rubber paper, and cut it into 2×3 cm pieces to obtain the drug film.

Embodiment 2

[0100] Coronary miltiorrhiza extract 4g, 1.7g methylcellulose, 4.5g vinylpyrrolidone-vinyl acetate-copolymer, 0.03g aspartose, 0.1g xanthan gum, 0.4g propylene glycol, dissolved in 12ml50% ethanol, A solution is formed, and the solution is smeared on silicone rubber paper with a squeegee, and the formed film of 300 microns is dried at 30°C for 30 minutes, and then dried at 60°C for 60 minutes, and the weight on the plane is 1000g / m 2 Next, form a film with a thickness of 80 microns, carefully remove it from the silicone rubber paper, and cut it into pieces of 2×3 cm to obtain the drug film.

Embodiment 3

[0102] Coronary miltiorrhiza extract 3.2g, 6.5g vinylpyrrolidone-vinyl acetate-copolymer, 0.02g sodium saccharin, 0.3gPEG400, dissolve in 12ml75% ethanol to form a solution, this solution is smeared on the silicone rubber paper with a squeegee , the formed film of 250 microns was dried at 30°C for 30 minutes, and then dried at 60°C for 60 minutes, with a plane weight of 100g / m 2 Next, form a film with a thickness of 75 microns, carefully remove it from the silicone rubber paper, and cut it into pieces of 2×3 cm to obtain the drug film.

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PUM

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Abstract

The present invention relates to one kind of Chinese medicine film preparation capable of dissolving in oral cavity fast. The film preparation consists of active Chinese medicine component(s) in 0.1-99 wt%, filming material in 0.1-90 wt% and medicinal supplementary material in 0-30 wt%. The active Chinese medicine components includes red sage extract, total arasaponin, breviscapine, gastrodine, acetyl gastrodine, etc. The Chinese medicine film preparation has convenient taking, fast absorption, high bioavailability, less irritation to digestive tract mucous membrane and other advantages, and is especially suitable for use in treating acute cardiac and cerebral vascular diseases and migraine.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, and more specifically relates to a Chinese medicine compound or a single herbal medicine film for the treatment of cardiovascular and cerebrovascular diseases and migraine, which can be quickly dissolved in the oral cavity and a preparation method thereof. Background technique [0002] According to the report of the World Health Organization in 1996, the number of cardiovascular and cerebrovascular diseases in the world has reached 14.6 million people every year. The incidence rate of cardiovascular and cerebrovascular diseases in China is 6%, and there are more than 75 million patients in the country. Due to the impact of population aging, the number of new cardiovascular diseases in my country is 1.5 million every year. The increase of cardiovascular and cerebrovascular patients has led to an increase in the demand for such drugs. The sales of cardiovascular drugs in m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/00A61K9/70A61K36/8988A61P9/00A61P25/06
Inventor 马素珍侯文彬周福军吴疆华洁阎立萍张新鑫
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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