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Grifola frondosa oral liquid rich in gastrodine, organic selenium and method for preparing the same

A technology of oral liquid and Grifola frondosa is applied in the directions of medical preparations, organic active ingredients, and pharmaceutical formulations containing active ingredients, which can solve the problem of no oral liquid coming out, and achieve the enhancement of human immunity and strong anti-tumor effect. Effect

Inactive Publication Date: 2008-06-11
GUIZHOU UNIV
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  • Abstract
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AI Technical Summary

Problems solved by technology

However, so far, there is no oral solution made of Grifola frondosa, gastrodin and trace element selenium.

Method used

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Examples

Experimental program
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Effect test

Embodiment

[0025] Grifola frondosa (strain number: 50404) was purchased from the Institute of Microbiology, Chinese Academy of Sciences, General Microbiology Center, China Committee for Culture Collection of Microorganisms.

[0026] The fermentation process is: (1) slant strain culture: use PDA medium to cultivate slant strains in a test tube at a temperature of 25°C for 8 days, pH 6.5 to 7.0; (2) Shake flask seed culture: liquid seed medium For: glucose 20g / L, corn flour 20g / L, bran flour 10g / L, K 2 HPO 4 1.5g / L, KH 2 PO 4 1g / L, MgSO 4 1g / L; culture conditions: cut the activated slant strains into soybean-sized bacterial blocks, inoculate 2-3 blocks in the liquid seed medium, fill 150ml in a 500ml triangular flask, cultivate on a rotary shaker, and rotate at a speed of 150r / min, culture temperature 25°C, pH6.5-7.0, culture time 7 days; (3) Gastrodia elata and bitter garlic raw material processing: use a pulverizer to crush the dried gastrodia elata and bitter garlic, and pass throu...

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Abstract

The invention discloses oral liquid of grey polypore which is rich in gastrodine and organic selenium and a process for preparation. Fresh gastrodia elata and bitter garlic are pre-processed, dried, and grinded by the invention, which take deep fermentation with grey polypore in powder shape to prepare oral solution which is rich in gastrodine, crude polysaccharide, and organic selenium. The process for preparation comprises first, culturing bacterial of a slant face of the grey polypore, second, culturing liquid seed, third, processing raw material which are gastrodia elata and bitter garlic, fourth, fermenting, fifth, post-treating products. In the oral liquid of the invention, the content of gastrodine is 2.2 to 2.8mg / 100ml, the content of crude polysaccharide is 4.0 to 4.8mg / L, and the content of organic selenium is 0.11*10-6 to 0.21*10-6. Compared with the prior art, the oral liquid of the invention can play a stronger effect of anti-tumor and enhance human immunity, and inhibit and kill cancer cells without hurting normal cells of human bodies simultaneously, which can service for human health. The process of the invention can lead gastrodine, bitter garlic, and grey polypore to be fermented together to prepare oral solution which is rich in gastrodine, crude polysaccharide, and organic selenium, and the oral solution can be produced in large scale.

Description

technical field [0001] The invention relates to the processing of edible fungi, in particular to a preparation method of an oral liquid containing functional ingredients of traditional Chinese medicine and fungal polysaccharide ingredients. Background technique [0002] Grifola frondosa (grifola frondosa), also known as polyporus frondosus, is a fungus with rich nutritional value and strong anti-tumor activity. main ingredient. In recent years, especially since 2000, the application of Grifola frondosa in the prevention and treatment of tumors has attracted people's attention. There are more than 50 patent applications involving Grifola frondosa, most of which were filed after 2000. Among these application documents, there are 2 applications that use the submerged fermentation of the medicinal fungus Grifola frondosa to produce Grifola frondosa oral liquid, namely ZL200410083062.X "A Grifola frondosa Oral Liquid and Its Production Method" and 200510062057.5 "A Preparation ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/06A61K36/8988C12N1/14A61P35/00A61K31/7034
Inventor 吴天祥
Owner GUIZHOU UNIV
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