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Gastrodine nosal spray preparation

A gastrodin and preparation technology, applied in the field of gastrodin nasal spray preparations, can solve the problems of increasing patient pain, side effects, and aggravating the mental burden of patients with nervous system diseases, so as to improve drug efficacy, high bioavailability, and good application prospects Effect

Inactive Publication Date: 2009-07-01
SHANGHAI SUNTECH PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although animal toxicity tests have shown that the toxicity of gastrodin is relatively low, frequent injections will increase the suffering of patients and increase the mental burden of patients with such neurological diseases, and there will be nausea and other gastrointestinal side effects when oral administration is large.

Method used

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  • Gastrodine nosal spray preparation
  • Gastrodine nosal spray preparation
  • Gastrodine nosal spray preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Formula: gastrodin 1g; Tween 20: 0.024g; polyethylene glycol 400: 192g; propylene glycol: 48g; EDTA disodium salt: 0.1g; benzalkonium chloride (50%): 0.3g; Make up to 1000g with water;

[0110] Preparation:

[0111] (1) Dissolve Tween 20 in 200g of water, shear and mix, add disodium edetate, benzalkonium chloride, and mix;

[0112] (2) Get 300g water and add gastrodin, propylene glycol, polyethylene glycol 400 successively and stir and mix;

[0113] (3) Add the mixed solution in (1) to (2), add water to 1000g in sufficient amount, stir and mix to obtain a clear, stable and transparent solution.

[0114] (4) Adjust pH to 6.5 with HCl (1mol / l) and NaOH (2mol / l) solution to obtain 1000g of clear, transparent, colorless, bubble-free fluid.

[0115] (5) Filling, dispensing and sealing the fluid obtained in (4) into a spray bottle. Each bottle of nasal spray contains 16.5g gastrodin nasal spray.

Embodiment 2

[0117] Formula: Cannabinoid 1g; Tween 20: 0.024g; Polyethylene glycol 400: 192g; Propylene glycol: 48g; Ethylenediamine

[0118] Disodium tetraacetate: 0.1g; benzalkonium chloride (50%): 0.3g; pure water to make up to 1000g;

[0119] The preparation method is the same as in Example 1.

Embodiment 3

[0121] Formula: Gastrodin 2g; Tween 20: 0.024g; Polyethylene glycol 400: 192g; Propylene glycol: 48g; EDTA disodium salt: 0.1g; Benzalkonium chloride (50%): 0.3g; Make up to 1000g with water;

[0122] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a nasal spray formulation of gastrodine. The inventive nasal spray formulation makes the gastrodine pass through the blood brain barrier to target to the brain by nasal administration, which is convenient in administration, and reduces the dosage and times of administration to reach the necessary medicament brain concentration, the concentration of peripheral drugs, and the burden of organs, such as kidney and liver. Furthermore, the nasal administration is especially suitable for children, old people, the bedridden, dysphagia patients, and patients in restriction of drinking water based on the medical order, in order to change the dependence of administration of patients and improve the effect of drugs.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation, in particular to a gastrodin nasal spray preparation for treating symptoms such as neurasthenia, neurasthenia syndrome, migraine and vertigo. Background technique: [0002] Gastrodin is the main active ingredient in Gastrodia elata, a perennial parasitic plant of Orchidaceae. The chemical name of gastrodin is p-hydroxymethylbenzene-β-D-glucopyranoside, white needle crystal, melting point 154°C-156°C. Pharmacological experiments have shown that gastrodin can restore the imbalance between the excitatory and inhibitory processes of the cerebral cortex, and has various pharmacological effects such as sedation, anticonvulsant, antiepileptic, analgesic, increasing cerebral blood flow, protecting nerve cells, and promoting energy metabolism of cardiomyocytes. Clinically, gastrodin has been widely used in the treatment of neurasthenia and traumatic brain injury syndrome, vertigo, neuralgia, headache, etc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/7034A61K47/34A61P25/06A61P25/20
Inventor 曾昭氚田杰夏春秀
Owner SHANGHAI SUNTECH PHARMA
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