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Improved gastrodine effervescence tablet and preparation method thereof

A technology of gastrodin and effervescent tablets, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, and pill delivery, and can solve problems such as large proportion of excipients, low bioavailability, and poor absorption

Inactive Publication Date: 2008-12-31
SUNSHINE LAKE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Ordinary tablets of gastrodin have long disintegration time, poor absorption, low bioavailability, large proportion of excipients, children, elderly patients with dysphagia are inconvenient to take, poor compliance, etc., which affect the therapeutic effect of gastrodin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Gastrodin 0.33g (0.1% by weight)

[0029] Sucrose 303.59g

[0030] Tartaric acid 16.7g

[0031] Sodium bicarbonate 16.7g

[0032] Disodium Glycyrrhizinate 3.34g

[0033] Orange flavor 1.67g

[0034] Scarlet Red 1.67g

[0035] Talc powder 5g

[0036] A total of 1000 pieces were made

[0037] Preparation method: mix 200-mesh gastrodin powder and 150-mesh lactose powder in equal increments; add the remaining excipient fillers, organic acids, inorganic bases, flavoring agents, taste-masking agents, coloring agents and lubricants in equal increments Mix evenly and pass through a 200-mesh sieve; add gastrodin and lactose mixed powder, mix evenly according to the method of equal increments, and directly compress into tablets.

Embodiment 2

[0039] Gastrodin 49.77g (14.9% by weight)

[0040] Lactose 254.15g

[0041] Citric acid 16.7g

[0042] Sodium carbonate 16.7g

[0043] Aspartame 3.34g

[0044] Glycyrrhizin 1.67g

[0045] Peach Flavor 1.67g

[0046] Orange 0.85g

[0047] Micronized silica gel 4.15g

[0048] A total of 1000 pieces were made

[0049] Preparation method: with embodiment 1.

Embodiment 3

[0051] Gastrodin 13.36g (4% by weight)

[0052] Sucrose 290.56g

[0053] Tartaric acid 16.7g

[0054] Sodium bicarbonate 16.7g

[0055] Disodium Glycyrrhizinate 3.34g

[0056] Orange flavor 1.67g

[0057] Scarlet Red 1.67g

[0058] Talc powder 5.0g

[0059] A total of 1000 pieces were made

[0060] Preparation method: with embodiment 1.

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PUM

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Abstract

The present invention relates to a gastrodin effervescent tablet which is assuasive and is used for remedying the insomnia and the cardiovascular neurogenic headache and a preparation method thereof. The present invention aims at providing the wide patient and the medical worker with a new preparation gastrodin effervescent tablet which is disintegrated and absorbed fast, has high bioavailability, is convenient for being taken with less intestinal residues and less side effect. Gastrodin is taken as the raw material, and the specific sorts of accessories in proportion are added. The gastrodin effervescent tablet is prepared by the technical measurement provided by the present invention, and a product of the present invention has sweet flavor with fragrance, takes effect fast, has high bioavailability and is very easy for improving the medication compliance of the patient.

Description

technical field [0001] The invention relates to a medicine which is convenient to take and a preparation method thereof, in particular to a gastrodin effervescent tablet for treating insomnia and cardiovascular nervous headache and a preparation method thereof. Background technique [0002] Gastrodin is the main component in the plant Gastrodia elata. Gastrodia elata is used for its underground tubers, and it is one of the well-known and commonly used traditional Chinese medicines in my country. "Compendium of Materia Medica" records that Gastrodia elata mainly treats rheumatic arthralgia, cramps in limbs, numbness in hands and feet, paralysis, headache, blood circulation, and waist and knees. Because the amount of gastrodin contained in the traditional Chinese medicine Gastrodia elata is very small, gastrodin is currently produced through synthesis. Its chemical name is: 4-hydroxyphenylglucopyranoside, and its molecular formula is: C 13 h 18 o 7 , molecular weight: 295....

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/7034A61P25/20A61P25/06
Inventor 王超志
Owner SUNSHINE LAKE PHARM CO LTD
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