61 results about "Blood vessel prosthesis" patented technology

A vascular prosthesis is described, having blunted wire ends. The blunted wire ends can take on a variety of configurations including end caps, bent ends, curved ends, or eyelets. The novel ends provide a smooth surface to contact the blood vessel walls thereby reducing the risk of trauma during placement of the prosthesis.

A deployment catheter for deploying endoluminal vascular prosthesis that has at least a main graft portion and a first branch graft portion includes an elongate, flexible catheter body having a proximal end and a distal end and comprising an outer sheath and an inner core that is axially moveable with respect to the outer sheath. The catheter includes a main graft restraint that has a main graft release mechanism comprising a plurality of axially spaced restraint members. The catheter further includes a branch graft restraint comprising a branch graft release mechanism.

An instrument for implanting an expandable cylindrical vascular prosthesis includes an outer tube and an inner tube which can be displaced relative to one another. The inner tube is longitudinally slotted on the distal end, at least in an area thereof, and ensheathes the stent with this area which includes the longitudinal slot. In order to implant the stent, the outer tube is retracted. The stent then expands with continuous retracting movement of the outer tube and the inner tube is pressed open along the longitudinal slot. Implantation is terminated, when the outer tube is retracted along the entire length of the stent. The implantation is reversible by pushing the outer tube forward, as long as the stent has not yet fully exited the instrument. In this way, the inner tube is constricted together with the stent, and compressed to an initial position.

A vascular prosthesis comprising a first layer having a predetermined first porosity and a second layer having a predetermined second porosity, wherein the first layer and the second layer are each made of first and second electrospun polymer fibers.

A guidewire assembly for use in deploying a bifurcated endoluminal vascular prosthesis that has a main graft portion and at least a first branch graft portion The guidewire assembly include a hollow guidewire sheath having a restraint mechanism, such as a tubular sheath, for constraining a branch graft portion of the vascular prosthesis and an inner core wire that is slidably insertable into a central lumen of the hollow guidewire sheath. In use, the guidewire assembly may be used with a deployment catheter to deploy the bifurcated vascular prosthesis and leave the inner core wire in position in the patient's aorta, extending through the main graft portion of the vascular prosthesis.

The present invention relates to decellularized vascular prostheses that are resistant to thrombus occlusion and have a low level of immunogenicity. The vascular prostheses are denuded of cells, and coated with an anti-thrombogenic agent and a growth factor that promotes recellularization and further reduces the immunogenicity. The prostheses have high mechanical strength, resist aneurysm rupture, and allow for secure surgical sutures while maintaining structural integrity. The present invention provides vascular prostheses that are blood vessels, valves or portions of vessels containing valves. The present invention is also useful for coating synthetic vascular stents.

The invention relates to clinical cardiology and cardiovascular surgery. The method for forming a blood flow in research stands and in surgically reconstructed segments of the blood circulation system comprises diagnosing the individual condition of a patient's blood circulation system; measuring the blood flow velocity field in the heart chambers and great vessels; comparing the parameters measured against the physiological norm; determining parameters forming a swirled blood flow; and modeling an individual swirled blood current in the blood circulation system being diagnosed, the streamlined surfaces and guide elements of flow channels of the blood circulation system reconstructed being given shapes conforming to the flow lines of the restored normally swirled blood flow in accordance with formulas:Q(t)=[z+Z0(t)]2(1.1)ϕ=ϕ0+k(t)z(1.2)k(t)=Γ0(t) / 4πQ(t)C0(t)Vz=2C0(t)zVr=-C0(t)rVϕ=Γ0(t)2πr{1-exp[-C0(t)r22v]}(1.3)wherein: Vr, Vz, and Vφ are the radial, longitudinal, and tangential velocities of the swirled current; v is the kinematic viscosity of the medium; φ0 is the initial swirling angle in relation to the flow axis normal; φ, z and r are current values of the angular, longitudinal, and radial coordinates along the flow line; and Q(t), Z0(t), k(t), Γ0(t), and C0(t) are parameters of the swirled blood flow variable over time because of the non-stationary current and corresponding to the individual normal indicators for a physiologically swirled blood flow. The normal indicators are established by routine examination of a representative sample of patients having no changes in the cardiovascular system. A vessel prosthesis comprises a tube having an internal surface in contact with the blood flow provided with a pattern to swirl the blood flow in accordance with formulas (1.1 to 1.3) conforming to a specific localization of the segment being reconstructed. A cannula for para-corporeal perfusion devices comprises a flow channel having an internal surface that is provided with a longitudinal pattern to swirl the blood flow, the shape of the pattern being determined from formulas (1.1 to 1.3), relative to the specific localization of the point where the cannula is inserted into the vessel channel. A heart valve prosthesis comprises one or more shutoff elements arranged symmetrically in the center of a body of round and / or oval cross-section, the streamlined surfaces of the valve being provided with a pattern in accordance with formulas (1.1 to 1.3). A blood pump comprises a flow swirling unit, a flow channel, and valves at the inlet and outlet of the channel, the surface washed over by blood being provided with a relief variable over time in accordance with formulas (1.1 to 1.3). A swirling device comprises an end piece having a streamlined surface provided with guides in the form of ribs, grooves, or blades of a shape defined by formulas (1.1 to 1.3), the swirling angle of the guides relative to the flow axis being varied optionally an operator or by a special-purpose device for modeling different current conditions.

In accordance with the present invention, there is provided a novel process for modifying the surface properties of a material that is suitable for contact with animal tissue so as to enhance its hemocompatibility and make it less thrombogenic when in use. This process comprises: Exposing the surface of the material to plasma treatment conditions in order to create reactive groups on said surface; activating a molecule with an activator to produce a reactive molecular species capable of forming convalent bonds with the reactive groups created on the surface of the material to form convalent bonds. The invention further encompasses the materials produced by this process as well as devices, such as vascular prosthesis, that are comprised of these process-modified materials.

A deployment catheter for deploying an endoluminal vascular prosthesis that has at least a main graft portion and a first branch graft portion. The deployment catheter preferably comprises an elongate, flexible catheter body having a proximal end and a distal end, and an outer sheath and an inner core that is axially moveable with respect to the outer sheath. The catheter preferably comprises a main graft restraint that has a main graft release mechanism comprising a main graft sheath and a suture threaded through a plurality of the openings in the main graft sheath. The catheter further comprises at least one branch graft restraint comprising at least one branch graft release mechanism.

With an insertion catheter for inserting a vascular prosthesis into a vessel, with an elongate, substantially tubular catheter cover having a proximal and a distal end, with an outlet for the vascular prosthesis provided at the distal end, in order to make insertion of the vascular prosthesis into the vessel particularly safe and simple, in particular, to provide the vascular prosthesis with protection against twisting, it is proposed that the outlet have a cross-sectional shape differing from a circular shape, and that the cross-sectional area defined by the outlet area be smaller than the cross-sectional area of the vascular prosthesis inserted in the vessel in the opened, unexpanded state.

A novel treatment for atherosclerotic vascular disease is described utilizing the implantation of a thin, conformable biocompatible prosthesis constructed from a composite of various structural and therapeutic scaffolds in combination with one or more bioactive agents. This prosthesis can be delivered into position over a lesion in order to passivate atherosclerotic plaques with minimal remodeling of the artery, or alternatively can be applied with a balloon to passivate the remodeled site. The composite prosthesis itself provides mild structural reinforcement of the vessel wall and an evenly distributed platform for the introduction of bioactive therapeutic agents.

The present invention relates to a vascular prosthesis for aneurysms (10, 10′) comprising a liner (2, 2′) that defines a lumen, the liner having at least a first terminal sleeve portion (22, 22′) with a first diameter (D1), at least a second terminal sleeve portion (24, 24′, 26′) with a second diameter (D2) and a body portion (20, 20′) extending between the first terminal sleeve portion and the second terminal sleeve portion, the body portion having at least one body diameter (D3) that is larger than the first diameter and the second diameter.

A medical device for implantation in a vessel is disclosed. The medical device comprises at least one anastomotic member, at least partially interposing a non-woven liner of electrospun fibers and a non-woven cover of electrospun fibers. The at least one anastomotic member is designed for engaging at least one end of the medical device to a wall of the vessel upon implantation of the medical device within the vessel.

A vascular prosthesis comprising a tubular support structure having an outer surface and an internal lumen therethrough, the support structure comprising a base material, which can comprise natural or synthetic materials, the internal lumen surface including an extracellular matrix (ECM) layer that includes at least one ECM material, wherein, when said vascular prosthesis is deployed proximate damaged cardiovascular tissue, the prosthesis induces modulated healing of the damaged tissue. In some embodiments, the support member outer surface also includes an ECM layer.

The invention discloses a blood vessel bracket prosthesis. The blood vessel bracket prosthesis comprises an artificial blood vessel prosthesis and a self-elasticity bracket, wherein the artificial blood vessel prosthesis is fixed on the outer side of the self-elasticity bracket through a suture line; the self-elasticity bracket consists of a plurality of self-expansion rings; the self-expansion rings are partially sutured on the artificial blood vessel prosthesis; a tube body of the artificial blood vessel prosthesis has a corrugate shape; the plurality of self-expansion rings are dispersedly arranged in the artificial blood vessel prosthesis at uniform intervals; and parts near the sides of the self-expansion rings, are sutured on the artificial blood vessel prosthesis. The blood vessel bracket prosthesis can avoid blood vessel deformation caused by that a tectorial membrane bracket is folded after being implanted into a human body and can avoid other problems caused by blood vessel deformation.

The invention discloses a soaking and coating method of artificial vessel silk protein, which is synthesized by woven or knitted elastic porous gap structure to coat at least five times through silk protein, wherein the false former of silk protein liquid vessel needs composite reinforcer, which is coated in the base layer evenly to expose in the formaldehyde steam after drying.

A vascular prosthesis, comprising a primary tubular structure of non-woven polymer fibers and a secondary tubular structure of non-woven polymer fibers, the primary and the secondary tubular structures being in fluid communication via an anastomosis such that the primary tubular structure terminates at the anastomosis and the secondary tubular structure continues at the anastomosis.

Disclosed is a bifurcated tubular endoluminal vascular prosthesis, useful in treating, for example, an abdominal aortic aneurysm. The prosthesis comprises a self expandable wire support structure surrounded at least in part by a flexible tubular membrane. A delivery catheter and methods are also disclosed.

The invention belongs to the technical field of medical biomaterial property test, and particularly relates to a biomechanical property testing device and a testing method for blood vessel prosthesis. The testing device includes a liquid storage box, a current guide silicon tube, an electronic peristaltic pump, a current limit switch, a conducting wire, a computer mounted with signal processing and converting software and data output equipment as well as a sample fixing device, a pressure testing device and a displacement testing device. By utilizing the device, the relation curve of the pressure and the tube diameter is measured and recorded in real time, so that the detecting results of compliance, fatigue resistance and bursting pressure are calculated and obtained, and the biomechanical properties of the blood vessel prosthesis are scientifically tested and evaluated; therefore, the technical problem of testing the biomechanical properties of the integral blood vessel prosthesis under the existing physiological status is solved, the integral testing and evaluation of the compliance, the fatigue resistance and the bursting pressure of the blood vessel prosthesis are realized, and scientific and reliable evidences are provided for choosing the blood vessel prosthesis with the biomechanical properties meeting the requirements.

The invention discloses a pre-coating method of artificial vessel collagen, which comprises the following steps: synthesizing vessel prosthese through woven or knitted elastic porous pipe structure, coating the collagen liquid with elasticizer for at least three times, setting the collagen in the base bottom evenly, drying to fix the collagen through heat-hinging method.

The invention provides an artificial blood vessel with a pre-coagulated coating. The artificial blood vessel comprises a textile blood vessel prosthesis and the biocompatible coating. The biocompatible coating with a toughening agent is applied to the blood vessel prosthesis, crosslinking is performed after multiple times of coating, and finally drying is performed. The pores and surface of the blood vessel prosthesis are filled with the coating, preoperative pre-coagulating operation is avoided, the softness and stiffness of the blood vessel prosthesis are improved, and the operating success rate and operation convenience are improved.