Artificial blood vessel with pre-coagulated coating

An artificial blood vessel and coating technology, applied in the field of artificial blood vessels, can solve problems such as blood leakage and easy cracking of the coating, achieve the effects of increasing softness and stiffness, simple preparation process, and improving success rate

Inactive Publication Date: 2017-01-04
JIANGSU BIODA LIFE SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the artificial blood vessel prepared by this method, the coating only exists on the surface of the artificial vascular prosthesis, and the pores are not filled. During the operation, when the doctor folds and sutures, the coating is easily broken, resulting in blood leakage

Method used

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  • Artificial blood vessel with pre-coagulated coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Freshly frozen bovine tendon was treated with 3% sodium carbonate for 30 minutes, and then soaked in 0.01M HCl solution for 2 hours. Treated bovine tendon with 1M NaSO 4 Treat for 30min, then soak in 0.5M NaOH for 10h. After washing 3 times with water, wash 3 times with 0.01M HCl solution. Freeze-dried for later use.

[0027] The polyester Y-shaped artificial blood vessel was prepared by weaving. Then prepare a bovine collagen solution with a concentration of 0.5 mg / mL and a plasticizer of glycerol with a concentration of 0.01 mg / ml. The collagen solution was injected into the artificial blood vessel with a diaphragm pump for 20 minutes. The artificial blood vessel was taken out, placed in a 30°C oven for drying, and the coating and drying operation was repeated 4 times.

[0028] The water permeability of the uncoated artificial blood vessel is 80ml / min·cm2. The water permeability test of the coated artificial blood vessel was found to be 1ml / min·cm2, which signif...

Embodiment 2

[0030] The polyester straight-tube artificial blood vessel was prepared by weaving. Then prepare a gelatin solution with a concentration of 1 mg / mL and a plasticizer of polyethylene glycol with a concentration of 0.03 mg / ml. In the airtight container, vacuumize the artificial blood vessel, so that the gelatin solution flows into the artificial blood vessel, and the vacuum degree is 0.1Mpa for 10 minutes. The artificial blood vessel was taken out, placed in a 40°C oven for drying, and the coating drying operation was performed 6 times.

[0031] The water permeability test of the coated artificial blood vessel was found to be 2ml / min·cm2, which significantly reduced the water permeability.

Embodiment 3

[0033] The polyester tubular artificial blood vessel is prepared by a knitting method, and after being shaped, three side branches are sutured on the main body. Porcine collagen was prepared according to the method in Example 1, and then a collagen solution was prepared with a concentration of 0.5 mg / mL, and the plasticizer was polyethylene glycol with a concentration of 0.02 mg / ml. Apply the collagen solution to the artificial blood vessel by piezoelectric spraying method, and spray for 10 minutes. The artificial blood vessel was taken out, placed in an oven at 50°C for drying, and the coating and drying operation was repeated 5 times. The water permeability test of the coated artificial blood vessel was found to be 0.5ml / min·cm2, which significantly reduced the water permeability.

[0034] In summary, a kind of artificial blood vessel with pre-coagulated coating provided by the present invention has the following advantages: 1) Utilize coating to fill the pores and surfaces...

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Abstract

The invention provides an artificial blood vessel with a pre-coagulated coating. The artificial blood vessel comprises a textile blood vessel prosthesis and the biocompatible coating. The biocompatible coating with a toughening agent is applied to the blood vessel prosthesis, crosslinking is performed after multiple times of coating, and finally drying is performed. The pores and surface of the blood vessel prosthesis are filled with the coating, preoperative pre-coagulating operation is avoided, the softness and stiffness of the blood vessel prosthesis are improved, and the operating success rate and operation convenience are improved.

Description

technical field [0001] The invention relates to a surgical implant of a medical device, in particular to an artificial blood vessel with a pre-coagulated coating. Background technique [0002] At present, it is an important surgical technique to replace human diseased blood vessels with artificial vascular prosthesis. Artificial blood vessels are usually constructed of biocompatible materials such as Dacron, Teflon, polyurethane, and natural mulberry silk. Weaving methods include knitting, weaving and weaving. [0003] The basal layer of the artificial blood vessel is composed of a porous fiber wall. The porous structure can keep the artificial blood vessel sufficiently tight to the blood to avoid excessive blood loss during the operation, and at the same time allow the infiltration and growth of fibroblasts and smooth muscle cells, making the recipient tissue wrap Healing vascular prosthesis. However, this type of artificial blood vessel needs pre-coagulation treatment w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06A61L27/22A61L27/18A61L27/16A61L27/34
CPCA61F2/06A61F2002/065A61F2230/0006A61F2240/002A61L27/16A61L27/18A61L27/227A61L27/34
Inventor 邢蕾
Owner JIANGSU BIODA LIFE SCI CO LTD
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