The invention discloses an orally taken granule for treating malaria and a preparation method thereof. The orally taken granule contains artesunate, coating material, stabilizer, filler, preservative and corrigent. 1000mg of oral liquid contains 60g of artesunate, 5g of coating material, 0.35g of stabilizer, 550g of filler, 1.2g of preservative and 5g of corrigent. The orally taken granule can overcome the shortage of infant medicines and can meet the requirement of infant for taste; plenty of documents and practices prove that the medicinal saccharose is taken as main filler, and meanwhile, the covering function of different coating materials for the bitter and the guiding functions of acesulfame and natural plant essence for gustation are surveyed, and the optimal tasty formula is screened through plenty of blinding data model researches.