Orally taken granule for treating malaria and preparation method thereof

Abstract

The invention discloses an orally taken granule for treating malaria and a preparation method thereof. The orally taken granule contains artesunate, coating material, stabilizer, filler, preservative and corrigent. 1000mg of oral liquid contains 60g of artesunate, 5g of coating material, 0.35g of stabilizer, 550g of filler, 1.2g of preservative and 5g of corrigent. The orally taken granule can overcome the shortage of infant medicines and can meet the requirement of infant for taste; plenty of documents and practices prove that the medicinal saccharose is taken as main filler, and meanwhile, the covering function of different coating materials for the bitter and the guiding functions of acesulfame and natural plant essence for gustation are surveyed, and the optimal tasty formula is screened through plenty of blinding data model researches.

Description

technical field [0001] The invention relates to an oral granule for treating malaria and a preparation method thereof, belonging to the field of chemical preparations. Background technique [0002] Artemisinin is extracted from the stems and leaves of the plant Artemisia annua. It is the most effective antimalarial drug after pyrimethamine, chloroquine and primaquine, especially for cerebral malaria and chloroquine-resistant malaria. It has been called by the World Health Organization as the only effective malaria treatment drug in the world. Since 1999, many companies have produced artemisinin drugs. [0003] Its derivatives currently include artemether, artesunate, dihydroartemisinin, etc. According to the "Guidelines for the treatment of malaria" issued by the World Health Organization (WHO), malaria is an important cause of morbidity and death among children and adults in tropical countries. The cause, currently, is that malaria is estimated to kill more than 1 million ...

AI Technical Summary

Problems solved by technology

[0004] At present, the main dosage forms on the market are tablets and injections. Injections have high requirements for storage and users. Infants and young children do not have high compliance with taking tablets, have a bad taste, are difficult to swallow, and are unwilling to cooperate with treatment; The chemical name of the ester (artesunate) is dihydroartemisinin-1,2-α-succinic acid monoester, which is an antimalarial drug obtained by changing the group on the basis of artesunate. As an ester drug, its stability Affected by high temperature, high humidity, acid-base, etc., the main drug is easily degraded, and the related substances exceed the standard, which seriously affects the safety and effectiveness of the drug. At the same time, its taste is bitter, and the compliance of infants and young children is not good.