In-vitro performance testing system and testing method of transcatheter bicuspid valve valved stent

Abstract

The invention discloses an in-vitro performance testing system and testing method of a transcatheter bicuspid valve valved stent, and relates to prostheses capable of being implanted in vivo, in particular to a testing device and testing method applied to heart valve performance testing. The in-vitro performance testing system comprises a valve testing part which is internally provided with the bicuspid valve valved stent, a liquid circulation device and a monitoring device; a first testing part is a heart specimen of which the left ventricular apex is provided with a circulation inlet, and asecond testing part is a section of artificial blood vessel or a section of blood vessel specimen for sewing the tested bicuspid valve valved stent; the liquid testing device is connected with the first testing part to constitute a first testing circulating path for steady flow circulation and a second testing circulating path for simulating the ventricular beat of the human body; the liquid circulation device is connected with the second testing part to constitute a third testing circulating path which is connected with circulation lateral branches, in vitro tests of fluid mechanic performance, support fixing states, valve backflow, perivalvular leakage, and influences on surrounding important organization structures of the bicuspid valve valved stent can be achieved, and a durability experiment of the bicuspid valve valved stent is completed.

Description

technical field [0001] The invention relates to a prosthesis that can be implanted in the body, in particular to a test device and a test method for testing the performance of heart valves. Background technique [0002] Mitral valve disease is one of the major heart diseases at present. It has various causes such as rheumatic, degenerative and congenital. Surgical valve replacement is the main means of treatment for patients with mitral valve disease. The technology of valve replacement surgery is mature, reliable and The effect is certain. However, the trauma is large and the risk is high. With the gradual promotion and use of percutaneous aortic valve replacement in clinic, the research on percutaneous mitral valve replacement has also aroused great interest. The anatomical structure of the mitral valve is complex, the positioning and fixation of the interventional artificial valve is difficult, and it is easy to injure the chordae or papillary muscles. Postoperative comp...

AI Technical Summary

Problems solved by technology

However, the trauma is large and the risk is high. With the gradual promotion and use of percutaneous aortic valve replacement in clinic, the research on percutaneous mitral valve replacement has also aroused great interest.

The anatomical structure of the mitral valve is complex, the positioning and fixation of the interventional artificial valve is difficult, and it is easy to injure the chordae or papillary muscles. Postoperative complications such as paravalvular leakage and left ventricular outflow tract stenosis are easily formed. research is relatively difficult

[0008] 1. Interventional pulmonary valve stents and interventional aortic valve stents are circular in design, while the overall shape of mitral valve stents is often a saddle-shaped design, which does not fully conform to the circular structure of blood vessels; the test site is artificial The design of the left ventricle, aorta, and coronary artery can only be used to test the characteristics of the aortic valve stent at the aortic valve position, and cannot be used for the implantation site at the junction of the left atrium and the left ventricle (ie, the mitral valve location) of mitral valve stents for testing

[0009] 2. Since the fixing device on the stent directly affects the characteristics of the stent in the blood vessel, the fixing characteristics of the mitral valve stent and its influence on the surrounding important tissue structures are also important contents of the in vitro test of the mitral valve stent. The valve stent is supported and fixed in the blood vessel, and the mitral valve stent is mainly fixed by barbs in the body. The test site of the above-mentioned prior art solution cannot test the fixing characteristics of the mitral valve stent and its impact on the surrounding area. The impact of important organizational structures

[0010] 3. The hemodynamics of the mitral valve is different from that of the aortic valve. The mitral valve is a channel between the chambers, which flows from the low-pressure atrium to the ventricle, and then closes to make the blood flow from the ventricle to the aorta, while the aortic valve is the left The blood flow of the ventricle flows to the aorta, so the circulation loop in the in vitro test is completely different. Simply passing the test circulation path of the above-mentioned prior art scheme cannot meet the in vitro test requirements of the mitral valve stent

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