9 results about "Merocyanine dye" patented technology

The present invention relates to the field of optical imaging. More specifically, the present invention relates to a class of monoalkylated cyanine dyes having red to near-infrared (650-900 nm) emission, characterized by pH responsiveness, and to conjugates thereof with biological ligands. The present invention also relates to the use of these compounds as optical diagnostic agents in the imaging or therapy of solid tumors, to methods for their preparation and to compositions containing them. The monoalkylated cyanine dyes have the general formula (I), in which R1 and R3 are independently selected from the group consisting of hydrogen, -SO3H, -COOH and -CONH-Y; and R2 and R4 are hydrogen, or R1 together with R2 and R3 together with R4 both form two aryl rings optionally substituted by 1 to 4 -SO3H groups together with the atoms to which they are bonded; R5 is an alkyl group optionally substituted by a group selected from -SO3H, -COOH and -CONH2. #imgabs0#

This invention relates to compounds and methods for treating cancer. In various embodiments, the compound includes a heptamethine carbocyanine dye (HMCD) component, a camptothecin derivative component, and a linker moiety (L) connecting the HMCD component and the camptothecin derivative component. In various embodiments, the method includes administering a therapeutically effective amount of the compound to a subject, thereby contacting a tissue of the subject with the compound such that the compound binds to the tissue; detecting the compound bound to the tissue, wherein the presence of the compound bound to the tissue is indicative of the cancer in the subject; and delivering the compound to the tissue thereby treating the cancer in the subject.

The invention relates to liquid sanitizing and / or disinfecting compositions comprising an active agent, an indicator compound, an acid, and a solvent. The compositions may be applied to a surface by spraying or transferring from cleaning article, in order to eliminate pathogens on the surface. The indicator compound may comprise a dye such as a cyanine dye, which provides a color to the composition and has at least one absorption maxima in the visible region. Once applied to the surface, the composition undergoes a color transition and becomes colorless.

A negative working lithographic printing plate precursor has a negative working infrared radiation sensitive image recording layer having a) two or more free radical polymerizable components; b) an initiator composition capable of generating free radicals; and c) one or more infrared radiation absorbing cyanine dyes. A) the two or more radically polymerizable components comprise a combination of a urethane (meth) acrylate and a polyester (meth) acrylate together making up 75-100% by weight of all the radically polymerizable components. The weight ratio of the urethane (meth) acrylate to the polyester (meth) acrylate is from 90: 10 to 35: 65. The urethane (meth) acrylate comprises one or more urethane linkages and at least 4 acrylate groups or methacrylate groups. The one or more polyester (meth) acrylates each do not contain a urethane bond and are represented by the following structure (I). These precursors are less sensitive to ambient ozone and can be imaged by infrared radiation and developed on-press during lithographic printing.

The present invention relates to a liquid disinfecting and / or bactericidal composition comprising an active agent, an indicator compound, an acid and a solvent. The composition can be applied to a surface by spraying or transferring from a cleaning article to eliminate pathogens on the surface. The indicator compound may include a dye, such as a cyanine dye, that provides a color to the composition and has at least one maximum absorption value in the visible light region. Once applied to the surface, the composition changes color and becomes colorless.

The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and / or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.

This invention relates to the field of optical imaging. More specifically, it relates to fluorescent probes capable of effectively targeting prostate-specific membrane antigen (PSMA) and comprising heptamethrin dye having near-infrared (NIR) emission. The invention also relates to methods for preparing these compounds, pharmaceutical compositions and kits for introducing these compounds, and methods for using them as optical diagnostic agents in the imaging or treatment of diseases, particularly prostate cancer.

The application belongs to the technical field of near-infrared organic dye synthesis, and particularly discloses a near-infrared two-region merocyanine dye, a preparation method and application thereof; the dye is 2-(2-(2-(N-benzylacetamide)-3-(2-(3-ethyl-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)ethylidene)cyclopent-1-en-1-yl)vinyl)-3-ethyl-1,1-dimethyl-1H-benzo[e]indol salt; the preparation method is simple, and raw materials are cheap and easy to obtain; the prepared near-infrared organic dye has high light stability, has strong fluorescence emission in the near-infrared two-region, and can be used as a contrast agent and applied to the field of near-infrared two-region biofluorescence imaging.

This invention is directed to a turn-on fluorescent probe, wherein said probe comprises a quinoline based cyanine dye derivative (QBC) and a specific protein binder covalently attached thereto directly or via a linker. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further describes methods for using these turn-on probes and compounds for detecting and labelling a wide range of proteins in their native environment.