8 results about "Hydroamination" patented technology

The invention discloses a method for preparing primary amine chemicals by hydrogenation amination of aldehyde and ketone through a platinum group monatomic doped nickel-based layered hydroxide catalyst, and belongs to the technical field of heterogeneous catalysis preparation of high-quality chemicals. The method comprises the following steps: by taking aldehyde and ketone chemicals as raw materials and ammonia gas as a gas source, carrying out hydrogenation amination reaction in a reaction solvent under the action of a platinum group monatomic doped nickel-based layered hydroxide catalyst and a hydrogen atmosphere to prepare a primary amine chemical; the platinum group single atom is any one of palladium, platinum, ruthenium, iridium or rhodium; wherein the effective active components on the nickel-based layered hydroxide carrier are composed of nickel metal and other metals, and the other metals are one or more of zinc, magnesium, aluminum, cerium, manganese, zirconium, iron, niobium or copper. The primary amine chemical prepared by the method has very high economic value.

A preparation method and use of a novel pure inorganic solid silicon-based sulfonic acid and / or phosphoric acid catalytic material are disclosed. The surface hydroxyl-rich metasilicic acid is used as the raw material, and by using a sulfonating reagent and / or phosphoric acid, the sulfonic acid group and / or the phosphoric acid group are bonded to the inorganic silicon material by chemical bonding to obtain a pure inorganic solid silicon-based sulfonic acid and / or phosphoric acid catalytic material. The catalytic material can be widely used in many acid-catalyzed organic reactions such as isomerization, esterification, alkylation, hydroamination of olefins, condensation, nitration, etherification, multi-component reactions and oxidation reactions. The inorganic solid silicon-based sulfonic acid and / or phosphoric acid catalytic material of the present invention has the advantages of high acid amount, high activity, good hydrothermal stability, no swelling, simple preparation, low cost, no pollution, no corrosion, easy separation and reusability.

The invention discloses a catalyst for synthesizing tetrahydropyrrole through hydroamination of furan as well as a preparation method and application of the catalyst, and belongs to the technical field of catalysis. According to the catalyst, an acidic amination catalyst is taken as a core, a composite oxide doped with hydrogenation active metal and an auxiliary agent is taken as a shell, an equivalent-volume impregnation method and a coprecipitation method are respectively adopted to prepare a core material and a shell layer material, then the shell layer is coated on the surface of the core through a rolling ball forming process, and the bifunctional catalyst with an eggshell-shaped structure is formed. According to the catalyst, tetrahydrofuran can be generated through hydrogenation of furan in a shell layer in a single reactor, then tetrahydrofuran is diffused to an inner core to be subjected to an amination reaction to generate tetrahydropyrrole, the problem of furan polymerization coking caused by coexistence of an acid center and hydrogenation activity on a traditional catalyst is effectively solved, the stability of the catalyst is remarkably improved, and the service life of the catalyst is remarkably prolonged. Meanwhile, the catalyst integrates two-step reaction, simplifies the process flow, and has the comprehensive advantages of high activity, high selectivity and good stability.

The application discloses a method for preparing primary amine chemicals by hydrogenation amination of aldehyde and ketone through a platinum group single-atom doped nickel-based layered hydroxide catalyst, and belongs to the technical field of heterogeneous catalysis for preparing high-quality chemicals. The method uses aldehyde and ketone chemicals as raw materials, ammonia gas as a gas source, and under the action of the platinum group single-atom doped nickel-based layered hydroxide catalyst, hydrogenation amination reaction is carried out in a reaction solvent under a hydrogen atmosphere to prepare primary amine chemicals; the platinum group single atom is any one of palladium, platinum, ruthenium, iridium or rhodium; wherein the effective active components on the nickel-based layered hydroxide carrier are composed of nickel metal and other metals, and the other metals are one or more of zinc, magnesium, aluminum, cerium, manganese, zirconium, iron, niobium or copper. The primary amine chemicals prepared by the method have very high economic value.

The invention belongs to the technical field of catalysts, and discloses a preparation method of a water-resistant multi-metal composite catalyst and application of the water-resistant multi-metal composite catalyst in preparation of polyether amine. The preparation method comprises the following steps: (1) mixing a nickel source, a lanthanum source, a chromium source and an aluminum source, adding a precipitant to carry out a co-precipitation reaction, and then aging and granulating to prepare metal hydroxide precipitation particles; and (2) dipping the metal hydroxide precipitation particles into a noble metal precursor solution, then roasting, processing and forming, and finally reducing to obtain the multi-metal composite catalyst. By optimizing the preparation process, high-dispersion noble metal active sites are formed, the catalytic activity and water resistance of the catalyst in hydroamination reaction can be effectively improved, and the cost is reduced. When being applied to synthesis of polyether amine, the catalyst can effectively resist the influence of water generated in synthesis reaction of polyether amine on the catalyst, prolong the service life of the catalyst and ensure long-term stable operation of the catalyst in actual production.

The application provides an asymmetric total synthesis method of alkaloid martinellic acid. Compared with the prior art, the asymmetric total synthesis method provided by the application constructs a pyrroloquinoline skeleton through a transition metal catalyst catalyzed tandem asymmetric cyclization reaction, and realizes carbon chain growth and amine group introduction through an olefin hydroamination carbonylation reaction, raw materials are simple and easy to obtain, the synthesis route is simple, and the conversion efficiency is high, so that the application provides a new idea and platform for drug molecule design and modification.

Disclosed in the present invention are an efficient and stable catalyst, and a preparation method therefor and a use thereof. The catalyst comprises a metal oxide support having a three-dimensional porous structure, and a polyoxometalate dispersed in a monomolecular state and attached to the metal oxide support, wherein the polyoxometalate is a proton-type polyoxometalate capable of providing hydrogen ions. Further, the catalyst also comprises an active metal component dispersed in a monatomic state and attached to one or both of the polyoxometalate and the metal oxide support. The present invention overcomes the problem in the prior art of inability to fully use the active sites of a polyoxometalate and a metal, has excellent catalytic activity and good stability, and is suitable for being used in reactions such as alkylation, esterification, hydrogenation, and amination.

The invention discloses a three-dimensional divergence method for synthesizing chiral amine through asymmetric hydroamination of nickel-catalyzed trisubstituted olefin and application of the three-dimensional divergence method in pharmaceutical molecule synthesis. The preparation method comprises the following steps: sequentially adding ethylene glycol dimethyl ether nickel dibromide, a direct-linked imidazole chiral ligand, a trisubstituted olefin compound, lithium hydroxide, potassium iodide, benzoyl hydroxylamine and tert-butyl alcohol into a dry glass reaction bottle, reacting at 30 DEG C by taking methyldiethoxysilane as a hydrogen source, and carrying out a reaction for 2-4 hours at the temperature of 30 DEG C; the fatty amine compound which is constructed by trisubstituted olefin and benzoyl hydroxylamine and has a continuous double chiral center is obtained. The continuous double-chiral central amine compound with various structures can be efficiently constructed by utilizing the method disclosed by the invention, and can be directly applied to later-stage modification of drug molecules. Meanwhile, the preparation method is efficient and convenient, and has excellent enantioselectivity, diastereoselectivity and regioselectivity; the synthesis route is safe and easy to implement, the cost is low, and the reaction operation and post-treatment process are simple. More importantly, the method has been successfully applied to construction of drug molecular skeleton derivatives with Moclobemide, Acecainide and the like, provides an efficient strategy for rapidly obtaining chiral amine compound libraries with various structures, and shows important application potential in the field of later modification and screening of drugs.