Application of paricalcitol in preparation of medicine for preventing and treating depression

A technology for paricalcitol and depression is applied in the field of use of paricalcitol in the preparation of drugs for preventing and treating depression, and can solve the problems of unclear anti-neuroinflammation effect of paricalcitol and the like
CN111467353AActive Publication Date: 2020-07-31LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
Publication Date
2020-07-31

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Abstract

The invention discloses a novel medical application of paricalcitol. According to the invention, through establishment of a depression mouse model, it is proved that paricalcitol can be used for preventing and treating depression induced by neuroinflammation, and the effective treatment amount is 0.1-1 [mu]g/kg body weight.
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Description

technical field

[0001] The invention relates to a new medical application of paricalcitol. Background technique

[0002] Vitamin D is an essential nutrient element for the human body, which can promote the absorption of calcium and phosphorus in the intestine, promote bone mineralization, and increase bone density [Lieben L, Masuyama R, Torrekens S, et al. Normocalcemia is maintained inmice under conditions of calcium malabsorption by vitamin D -inducedinhibition of bone mineralization[J].J Clin Invest,2012,122(5):1803-1815.】, and inhibit the high bone turnover caused by hyperparathyroidism by reducing the release of parathyroid hormone (PTH)【 Khundmiri SJ, Murray RD, Lederer E. PTH and Vitamin D [J]. Compr Physiol, 2016, 6(2):561-601.]. More and more clinical data show that vitamin D also plays an important role in cardiovascular, immune, tumor, pregnancy and fetal development [Lin Z, Li W. The Roles of Vitamin D and Its Analogs in Inflammatory Diseases[J ]. Curr Top Med ...

Claims

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