Application of paricalcitol in preparation of medicine for preventing and treating depression

Abstract

The invention discloses a novel medical application of paricalcitol. According to the invention, through establishment of a depression mouse model, it is proved that paricalcitol can be used for preventing and treating depression induced by neuroinflammation, and the effective treatment amount is 0.1-1 [mu]g/kg body weight.

Description

technical field [0001] The invention relates to a new medical application of paricalcitol. Background technique [0002] Vitamin D is an essential nutrient element for the human body, which can promote the absorption of calcium and phosphorus in the intestine, promote bone mineralization, and increase bone density [Lieben L, Masuyama R, Torrekens S, et al. Normocalcemia is maintained inmice under conditions of calcium malabsorption by vitamin D -inducedinhibition of bone mineralization[J].J Clin Invest,2012,122(5):1803-1815.】, and inhibit the high bone turnover caused by hyperparathyroidism by reducing the release of parathyroid hormone (PTH)【 Khundmiri SJ, Murray RD, Lederer E. PTH and Vitamin D [J]. Compr Physiol, 2016, 6(2):561-601.]. More and more clinical data show that vitamin D also plays an important role in cardiovascular, immune, tumor, pregnancy and fetal development [Lin Z, Li W. The Roles of Vitamin D and Its Analogs in Inflammatory Diseases[J ]. Curr Top Med ...

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