The invention discloses a preparation method of a nano
chitosan antibacterial synergist, which comprises the following steps: dissolving
chitosan in
acetic acid, and standing overnight after dissolving until no obvious particles exist to obtain a
chitosan solution; adding an
antibacterial drug into the chitosan solution, performing magnetic stirring, and then adding a cross-linking agent to obtain the nano chitosan antibacterial synergist. The nano chitosan conjugated
penicillin is used for the first time, the effect of the nano chitosan conjugated
penicillin on clinical
drug-resistant
escherichia coli is verified, application possibility is provided for reducing use and
drug residues of clinical drugs, and compared with a current common antibiotic treatment method, the nano chitosan conjugated
penicillin has the advantages that the application range is wide; the preparation method has the advantages that the
antibacterial effect is improved, the
drug use amount is reduced, drug residues are reduced, the
drug resistance problem is solved, and the preparation method is simple and convenient. According to the research, on the basis of drug-resistant
escherichia coli, nano chitosan antibacterial synergists with different concentrations are added, and the
antibacterial effect of the nano chitosan antibacterial synergists on the drug-resistant
escherichia coli is evaluated. And a certain theoretical and experimental basis is provided for clinical medication.