Hepatic functional reserve detector capable of removing blood oxygen fluctuation interference

Abstract

The invention relates to a hepatic functional reserve detector capable of removing blood oxygen fluctuation interference. The hepatic functional reserve detector consists of a photoelectric finger clip sensor, a data memory, a liquid crystal display module, a light source driving circuit, a microprocessor, a signal separating circuit, a signal amplifying circuit, an A / D (analog / digital) conversion circuit, a wireless communication module and a computer, the photoelectric finger clip sensor is respectively connected with the data memory and the liquid crystal display module via the light source driving circuit and the microprocessor, the photoelectric finger clip sensor is connected with the microprocessor via the signal separating circuit, the signal amplifying circuit and the A / D conversion circuit, the microprocessor is connected with the wireless communication module, and the computer is connected with the wireless communication module via Bluetooth. A concentration spectrum of indocyanine green (ICG) pigment used as indicator is separated from a blood oxygen absorbing spectrum, inference of low blood oxygen and blood oxygen fluctuation to pigment concentration measurement is suppressed, a diluted concentration curve of the ICG pigment injected via a vein is accurately measured, the purpose of non-invasively and continuously measuring cardiovascular and hepatic haemodynamics parameters such as pigment blood plasma disappearance rate K, 15-minute detaining rate R15 and the like is achieved, surgery risks can be accurately predicted by means of detecting hepatic functional reserve, a proper therapy mode is selected, and operative mortality and postoperative complications can be effectively reduced.

Description

Technical field: [0001] The invention relates to a pigment dilution and excretion test method and a detection device for detecting liver reserve function based on the principle of pulse spectrophotometry. By separating the blood oxygen absorption spectrum from the pigment concentration spectrum, the interference of low blood oxygen and blood oxygen fluctuations on the measurement of pigment concentration is suppressed, and the accurate measurement of the dilution concentration curve of indocyanine green pigment injected intravenously is achieved, achieving non-invasive and continuous Measure the pigment plasma disappearance rate K and 15-minute retention rate R 15 Cardiovascular and hepatic hemodynamic parameters. Background technique: [0002] Liver disease is an important human disease with a global distribution. There are 350 million liver disease patients in the world, and more than 1 million people die of liver disease every year. Liver reserve function refers to the ...

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Problems solved by technology

Although the instrument realizes the liver function test without blood collection, in the calculation of the liver function test, only the pulsating component of the transmitted light is considered, and the direct current component absorbed by human skin and muscle tissue is not included, nor is it taken into account in the arterial blood. Oxygenation and deoxygenation reactions that occur in hemoglobin affect the absorbance, so there is a systematic error in the measurement results

[0007] In the prior art, there is no photoelectric technology that separates the concentration spectrum of the ICG pigment used as an indicator from the blood oxygen absorption spectrum, and realizes the non-invasive and continuous detection of liver reserve function under the interference of low blood oxygen and blood oxygen fluctuations. pulse pigment density method

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