Antibacterial cation-modified absorbable pachymeninx repair material and preparation method and application thereof

A repair material and cationic technology, which is applied in the field of antibacterial cationic modified absorbable artificial dura mater and its preparation, can solve the problem of the antibacterial properties of polycaprolactone electrospun fiber membrane scaffold materials and the inability to achieve long-term antibacterial properties. Bacteria and other problems, to achieve good application prospects, easy to control product quality, simple preparation process effect

Active Publication Date: 2017-05-17
YANTAI ZHENGHAI BIO TECH
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  • Summary
  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

The polylysine in this patent is added to the inside of the dressing fiber by directly mixing it into the polymer spinning solution. The disadvantage is that the polylysine component is easily freed from the dressing when it comes into contact with the wound surface. Unable to achieve the purpose of long-term antibacterial
This method focuses on i

Method used

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  • Antibacterial cation-modified absorbable pachymeninx repair material and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0053] Dissolve polylactic acid-caprolactone copolymer (PLCL) with a weight average molecular weight of 300,000 in hexafluoroisopropanol at a concentration of 0.08 g / ml, and form a uniform and stable solution after stirring at room temperature. The solution is then put into a syringe, and the needle of the syringe is connected to a high-voltage power supply. The solution supply flow rate was controlled at 1 ml / hour, the applied voltage was 15 kV, the distance between the high-voltage end and the ground end was 15 cm, and a rotating drum with a diameter of 8 cm was used as a collection device at a speed of 100 rpm. After spinning the PLCL solution, a nanofiber film with a thickness of about 0.2 mm can be collected.

[0054] Place the PLCL nanofiber membrane in a low-temperature plasma reaction chamber, close the reaction chamber and evacuate to 5Pa, then pass in helium gas, and adjust the working pressure to 20Pa. After the airflow is stable, turn on the radio frequency power ...

Embodiment 2

[0058] Dissolve poly-L-lactic acid (PLLA) with a weight average molecular weight of 300,000 in chloroform at a concentration of 0.1 g / ml, and form a uniform and stable solution after stirring at room temperature. The solution is then put into a syringe, and the needle of the syringe is connected to a high-voltage power supply. The solution supply flow rate was controlled at 1.5 ml / hour, the applied voltage was 17.5 kV, the distance between the high-voltage end and the ground end was 12.5 cm, and a rotating drum with a diameter of 8 cm was used as a collection device at a speed of 100 rpm. After spinning the PLLA solution, a nanofiber film with a thickness of about 0.25 mm can be collected.

[0059] At 4°C, the PLLA nanofiber membrane was soaked in a 0.1M sodium hydroxide solution for 15 minutes, and then the fiber membrane was taken out and washed with a large amount of deionized water. At 4 °C, the carboxylated PLLA nanofiber membrane was soaked in a mixed solution containin...

Embodiment 3

[0062] Polylactic acid-glycolic acid copolymer (PLGA) with a weight average molecular weight of 250,000 was dissolved in acetone at a concentration of 0.2 g / ml, and a uniform and stable solution was formed after stirring at room temperature. The solution is then put into a syringe, and the needle of the syringe is connected to a high-voltage power supply. The solution supply flow rate was controlled at 2 ml / hour, the applied voltage was 20 kV, the distance between the high voltage end and the ground end was 20 cm, and a rotating drum with a diameter of 8 cm was used as the collection device at a speed of 100 rpm. After spinning the PLGA solution, a nanofiber film with a thickness of about 0.15 mm can be collected.

[0063] Soak the PLGA nanofiber membrane in a hydrogen peroxide solution with a volume fraction of 10%, and then place it under a UV lamp with a wavelength of 350nm and a power of 40W at a distance of 10cm. After reacting for 30 minutes, take it out and wash it with...

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Abstract

The invention belongs to the field of regenerative medicine materials, and in particular relates to an antibacterial cation-modified absorbable pachymeninx repair material and a preparation method and application thereof. The antibacterial cation-modified absorbable pachymeninx repair material is of a double-layer structure consisting of a degradable polyester nanofiber membrane modified by epsilon-polylysine and a three-dimensional porous high-molecular material. The absorbable pachymeninx repair material provided by the invention has excellent antibacterial characteristic, can effectively prevent postoperative intracranial infection, and can be directly attached and sewed for use; product compositions and a preparation process are simple, and industrial production are easily realized. The antibacterial cation-modified absorbable pachymeninx repair material of the invention is a novel medical biological material which is novel in structure and excellent in performance, and presents a good application prospect in the field of pachymeninx defect repair.

Description

technical field [0001] The invention belongs to the field of regenerative medical materials, and in particular relates to an antibacterial cationic modified absorbable artificial dura mater and its preparation method and application. Background technique [0002] The dura mater is a layer of connective tissue that lines the inside of the skull and the outside of the brain and acts as a natural barrier to protect brain tissue. Open skull injury, tumor metastasis, and other brain diseases can cause dural defects, which in turn lead to cerebrospinal fluid leakage. At the same time, intracranial infection caused by bacterial meningitis is still a common serious complication after craniocerebral surgery. Reported in the literature, the incidence of postoperative intracranial infection is still as high as 0.2% to 5%. Once an infection occurs after the operation, it will not only greatly increase the medical expenses of the patient, but also lead to the failure of the operation a...

Claims

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Application Information

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IPC IPC(8): A61L27/58A61L27/56A61L27/18A61L27/20A61L27/54A61L27/40D01F6/62D06M15/59D06M101/32
Inventor 窦源东任志伟孙先昌尹晓彤陈振华
Owner YANTAI ZHENGHAI BIO TECH
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