Nimodipine emulsion injection liquid and method for preparing the same
A technology of nimodipine milk and nimodipine, which is applied in the direction of emulsion delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of hindering blood coagulation, prolonging the time of crystallization, general effect, etc., and achieve storage and Ease of use, enhanced solubility, stable content
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Embodiment 1
[0070] Under nitrogen protection, weigh 50 g of soybean oil for injection and heat it to 70 ° C. Under high-speed stirring, add 5 g of egg yolk lecithin, 0.1 g of nimodipine, and 0.5 g of benzyl alcohol, and stir evenly as the oil phase; 10 g of glycerin for injection Add to 600ml of water for injection, mix well and filter with a 0.45μm membrane as the water phase. Add the oil phase to the water phase under high speed stirring to make colostrum. Measure the pH value to 6.0, add water for injection to 1000ml, homogenize repeatedly through a high-pressure homogenizer, and check the size of the milk particles. The particle size of all particles is less than 1 μm. After the emulsion is filtered, it is filled with nitrogen, sealed, and sterilized by rotary steam. After cooling, nimodipine milk injection is obtained after passing the inspection.
Embodiment 2
[0072] Under the protection of nitrogen, weigh 300g of soybean oil for injection and heat it to 80°C. Under high-speed stirring, add 30g of egg yolk lecithin, 3g of nimodipine, and 50g of benzyl alcohol, and stir evenly as the oil phase; add 50g of glycerin for injection into 500ml In water for injection, mix well and filter with a 0.45 μm filter membrane as the water phase. Add the oil phase to the water phase under high speed stirring to make colostrum. Measure the pH value to be 8.0, add water for injection to 1000ml, homogenize repeatedly through a high-pressure homogenizer, and check the size of the milk particles. The particle size of all particles is less than 1 μm. After the emulsion is filtered, it is filled with nitrogen, sealed, and sterilized by rotary steam. After cooling, nimodipine milk injection is obtained.
Embodiment 3
[0074] Under nitrogen protection, weigh 100g of soybean oil for injection and heat it to 75°C. Under high-speed stirring, add 12g of egg yolk lecithin, 1g of nimodipine, and 10g of benzyl alcohol, and stir evenly as the oil phase; add 22.5g of glycerin for injection 600ml water for injection, mix well and filter with a 0.45μm filter membrane as the water phase. Add the oil phase to the water phase under high speed stirring to make colostrum. Measure the pH value to 7.0, add water for injection to 1000ml, homogenize repeatedly through a high-pressure homogenizer, and check the size of the milk particles. The particle size of all particles is less than 1 μm. After the emulsion is filtered, it is filled with nitrogen, sealed, and sterilized by rotary steam. After cooling, nimodipine milk injection is obtained.
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