Nimodipine emulsion injection liquid and method for preparing the same

[0069] Example 1

[0070] Under the protection of nitrogen, weigh 50g of soybean oil for injection and heat it to 70°C, add 5g egg yolk lecithin, 0.1g nimodipine, and 0.5g benzyl alcohol under high-speed stirring, and stir evenly as the oil phase; use 10g glycerin for injection Add to 600ml water for injection, mix well and filter with 0.45μm filter membrane as the water phase. Add the oil phase to the water phase under high-speed stirring to make colostrum. Measure the pH value to be 6.0, add water for injection to 1000ml, repeat homogenization by a high-pressure homogenizer, check the size of the milk particles, and all the particles are less than 1μm in diameter. After the emulsion is filtered, it is filled and sealed with nitrogen, and sterilized by rotary steam. After cooling, the nimodipine emulsion injection is obtained after passing the inspection.

[0071] Example 2

[0072] Under the protection of nitrogen, weigh 300g of soybean oil for injection and heat it to 80℃. Under high-speed stirring, add 30g of egg yolk lecithin, 3g of nimodipine, and 50g of benzyl alcohol. Stir evenly as the oil phase; add 50g of glycerin for injection to 500ml In the water for injection, mix well and filter it with a 0.45μm filter membrane as the water phase. Add the oil phase to the water phase under high-speed stirring to make colostrum. Measure the pH value to 8.0, add water for injection to 1000ml, repeat homogenization with a high-pressure homogenizer, check the size of the milk particles, and all the particles are less than 1μm in diameter. After the emulsion is filtered, it is filled and sealed with nitrogen, and sterilized by rotary steam. Nimodipine emulsion injection is obtained after cooling.

[0073] Example 3

[0074] Under the protection of nitrogen, weigh 100g of soybean oil for injection and heat to 75℃. Under high-speed stirring, add 12g of egg yolk lecithin, 1g of nimodipine, and 10g of benzyl alcohol. Stir evenly as the oil phase; add 22.5g of glycerin for injection In 600ml of water for injection, mix well and filter with 0.45μm membrane filter as the water phase. Add the oil phase to the water phase under high-speed stirring to make colostrum. Measure the pH value to 7.0, add water for injection to 1000ml, and repeat the homogenization with a high-pressure homogenizer to check the size of the milk particles, and all the particles are less than 1μm in diameter. After the emulsion is filtered, it is filled and sealed with nitrogen, and sterilized by rotary steam. Nimodipine emulsion injection is obtained after cooling.