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Chinese medicinal essential oil injection solution, injection and preparation method thereof

A technology for volatile oil and injection, applied in the field of medicine, can solve problems such as difficulty in overcoming long-term storage stability, and achieve the effects of solving stability problems, simple preparation process and high safety

Inactive Publication Date: 2010-05-19
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the fat emulsion is still a water dispersion system, it is difficult to overcome the long-term storage stability of drugs with poor stability in water (such as traditional Chinese medicine volatile oil)
Therefore, so far, there is no report that the Chinese medicine volatile oil is prepared into injections for clinical use with injection emulsions as the dispersion medium.

Method used

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  • Chinese medicinal essential oil injection solution, injection and preparation method thereof
  • Chinese medicinal essential oil injection solution, injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Embodiment 1 prepares allicin injection solution and injection thereof

[0051] 1. Preparation of Allicin Injection Solution

[0052] Weigh 1.0 g of allicin, 0.002 g of vitamin E, and 0.001 g of disodium edetate, add them to an appropriate amount of polyethylene glycol 400, stir and dissolve at 35 ° C, and then dilute to 100 with polyethylene glycol 400 mL; use citric acid to adjust the pH value to 4.50; add 0.1 g of activated carbon for needles, adsorb for 30 minutes at a temperature of 35 ° C, then filter with a 0.22 μm microporous membrane, pack into glass or plastic bottles, seal, and use Sterilize with circulating steam at 100°C for 30 minutes, and store for later use.

[0053] 2. Preparation of Emulsion for Injection

[0054] Weigh 100 grams of caprylic triglyceride for injection, 100 grams of soybean oil, heat in a water bath to 78°C, add 12 grams of egg yolk phospholipids for injection, cut to dissolve, stir and mix to obtain the oil phase; measure 750 grams o...

Embodiment 2

[0061] Embodiment 2 prepares allicin injection solution and injection thereof

[0062] 1. Preparation of Allicin Injection Solution

[0063] Weigh 1.2 grams of allicin and 0.01 grams of vitamin E, add them to 15 grams of absolute ethanol and 75 grams of polyethylene glycol 400, stir and dissolve at 25°C, and then dilute to 100 ml with polyethylene glycol 400; Use lactic acid to adjust the pH value to 4.55; add 0.2 grams of activated carbon for needles, absorb at a temperature of 30 ° C for 25 minutes, then filter with a 0.22 μm microporous membrane, pack in plastic or glass bottles, seal, and use circulating steam Sterilize at 100°C for 45 minutes and store for future use.

[0064] 2. Preparation of Emulsion for Injection

[0065] Weigh 100 grams of soybean oil and 100 grams of caprylic triglyceride, mix them, heat in a water bath to 85°C, add 12 grams of egg yolk phospholipids for injection, cut and dissolve to obtain an oil phase; measure 750 ml of water for injection, add...

Embodiment 3

[0070] Embodiment 3 prepares allicin injection solution

[0071] Weigh 1.5 grams of allicin and 0.005 grams of disodium ethylenediaminetetraacetate, add them to an appropriate amount of polyethylene glycol 400, stir and dissolve at 28 ° C, and dilute to 100 ml with polyethylene glycol 400; add 2.8 grams of needle Use activated carbon to absorb at a temperature of 35°C for 15 minutes, then filter with a capsule filter, pack in glass bottles or plastic bottles, sterilize with high-pressure steam at 121°C for 15 minutes, and store for later use.

[0072] When administering, mix the above-mentioned prepared allicin injection solution with the commercially available injection emulsion (manufactured by Guangzhou Baite Qiaoguang Medical Supplies Co., Ltd., specification: 100 ml, 20% medium / long-chain fat emulsion, batch number: GM0809034) by volume ratio 1:40 mixing, into allicin injection, can be administered intravenously.

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Abstract

The invention relates to the technical field of medicaments, and discloses a Chinese medicinal essential oil injection solution, an injection thereof and a preparation method thereof. The invention provides a stable and safe Chinese medicinal essential oil injection without Tween-80, which consists of the Chinese medicinal essential oil injection solution and a dispersion medium, wherein the Chinese medicinal essential oil injection solution consists of a Chinese medicinal essential oil, a stabilizing agent, a pH value regulator and a solvent for injection; and the dispersion medium is an emulsion for injection. When in clinical medication, the Chinese medicinal essential oil injection solution is dispersed in the emulsion for the injection and is prepared into the Chinese medicinal essential oil injection, and then the intravenously administrable can be performed. In the invention, the Chinese medicinal essential oil injection solution and the emulsion for the injection are packaged and stored respectively so that the stability of a medicament stored for a long time can be improved. The invention provides a harmfulless, safe and conveniently-stored intravenous injection for the Chinese medicinal essential oil.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to a traditional Chinese medicine volatile oil injection solution, an injection and a preparation method thereof. Background technique [0002] Volatile oil of traditional Chinese medicine is a kind of oily liquid substance which is volatile and can be distilled out with water vapor, and mostly has aromatic gas. There are many Chinese herbal medicines containing volatile oil, especially Lamiaceae (mint, perilla, artemisia, etc.), Umbelliferae (fennel, angelica, coriander, Angelica dahurica, Chuanxiong, etc.), Compositae (artemisia argyi, capillary, herb, Atractylodes , woody, etc.), Rutaceae (orange, tangerine, pepper, etc.), Lauraceae (camphorae, cinnamon, etc.), Zingiberaceae (ginger, turmeric, turmeric, etc.) are more abundant. Most of the extracted volatile oils or Chinese herbal medicines containing volatile oils have antibacterial, immune-enhancing, anti-tumor effects. [000...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K36/78A61K36/11A61K36/708A61K36/282A61K36/9068A61K31/10A61K9/08A61K9/107A61P31/04A61P37/04A61P35/00
CPCA61K9/0019A61P31/04
Inventor 陈建明高保安刘薇陈明邓莉刘文丽黄硕杨秋霞孙靖顾芃张莹莹张佳良
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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