Ambroxol hydrochloride injection

A kind of technology of ambroxol hydrochloride and injection, applied in the field of pharmaceutical preparations

Active Publication Date: 2009-04-29
天津康哲维盛医药科技发展有限公司
View PDF0 Cites 44 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The ambroxol hydrochloride injection that is determined through systematic test research screeni

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Ambroxol hydrochloride injection
  • Ambroxol hydrochloride injection
  • Ambroxol hydrochloride injection

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0039] 1000 pieces

[0040] prescription:

[0041] Ambroxol hydrochloride 15.0g,

[0042] Citric acid 2.0g,

[0043] Sodium dihydrogen phosphate 6.0g,

[0044] Sodium chloride 18.0g,

[0045] Add water for injection to 2000ml.

[0046] Process:

[0047] First add 1000ml water for injection in the container, add citric acid, sodium dihydrogen phosphate, sodium chloride in sequence, stir and dissolve at room temperature for about 30 minutes, add 1mol / L hydrochloric acid or 1mol / L sodium hydroxide to adjust the pH to 3-5, Add ambroxol hydrochloride and stir well to dissolve it completely. Add 0.1% activated carbon, stir at room temperature for 20 minutes, filter to remove the carbon, add the remaining water for injection to make up the amount, determine the intermediate content, finely filter, potting and sterilizing each bottle with 2ml to obtain ambroxol hydrochloride injection.

Example Embodiment

[0048] 1000 pieces

[0049] prescription:

[0050] Ambroxol hydrochloride 30.0g,

[0051] Phosphoric acid 1.0g,

[0052] Mannitol 40.0g,

[0053] Sorbitol 25.0g,

[0054] Sodium chloride 9.0g,

[0055] Add water for injection to 1000ml.

[0056] Process:

[0057] First add 800ml of water for injection in the container, add mannitol, sorbitol, and sodium chloride in sequence to dissolve at room temperature for about 30 minutes, add 0.1mol / L phosphoric acid or potassium hydroxide to adjust the pH to 3-5, add ambroxol hydrochloride fully Stir to dissolve completely. Add the remaining water for injection to make up the full amount, add 0.2% activated carbon, stir for 20 minutes at room temperature, decarburize, filter and sterilize with a microporous membrane, the filtrate is divided into 1ml each, pre-frozen for 3 hours, and dried under reduced pressure under freezing After 15 hours, when the sample temperature reaches room temperature, it is dried for another 5 hours to obtain a wh...

Example Embodiment

[0058] 100 pieces

[0059] prescription:

[0060] Ambroxol hydrochloride 15.0g,

[0061] Hydrochloric acid 2.0g,

[0062] Sodium bicarbonate 6.0g,

[0063] Sodium chloride 90.0g,

[0064] Add water for injection to 10000ml.

[0065] Process:

[0066] First add 8000ml water for injection in the container, add sodium bicarbonate and sodium chloride successively to dissolve at room temperature for about 30 minutes, add 1mol / L hydrochloric acid or 1mol / L ammonium hydroxide to adjust the pH to 3-5, add ambroxol hydrochloride fully Stir to dissolve completely. Add 0.1% activated carbon, stir at room temperature for 20 minutes, filter to remove the carbon, add the remaining water for injection to make up the amount, determine the intermediate content, fine filter, fill and sterilize each with 100ml, that is, ambroxol hydrochloride and sodium chloride injection liquid.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a medicinal preparation, in particular to an ambroxol hydrochloride injection which is a stable medial composition taking ambroxol hydrochloride as an active ingredient to be combined with carriers acceptable in pharmacy. The carriers comprise a water-soluble filling agent, a pH regulating agent, a stabilizing agent, water used for injection or an osmotic pressure regulating agent and the like. As the carriers are adopted to carry out scientific preparation, the drug quality and medication safety of freeze-dried powder injections, small-needle injections and small infusion solutions are ensured, and the stability of the preparations during storage is improved.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation, more specifically, an expectorant drug-ambroxol hydrochloride injection. Background technique: [0002] The chemical name of ambroxol hydrochloride is: trans 4-[(2-amino-3,5 dibromo-phenyl) methyl-amino] cyclohexanol, and its structure is as follows: [0003] [0004] Ambroxol hydrochloride is a new generation of airway mucus regulator, which has excellent expectorant effect and can significantly promote the synthesis and secretion of alveolar surfactant. Ambroxol hydrochloride can stimulate bronchial mucous glands to secrete more fluid mucus, dilute sputum, reduce viscosity, and increase the production and secretion of pulmonary surfactant, thereby reducing airway resistance and mucus adhesion. Activates mucociliary blanket function and promotes mucociliary transport. Compared with the first-generation and second-generation expectorant drugs, ambroxol hydrochloride, in addition to its powerf...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/137A61K9/08A61K9/19A61K47/12A61P11/10
Inventor 邹美香孙歆慧任晓文吴疆张彩霞
Owner 天津康哲维盛医药科技发展有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap